[The antiaggregant action of 2-morpholino-5-(thienyl-2)-6-H-1,3,4-thiadiazine in in vitro and ex vivo experiments].

The influence of 2-morpholino-5-(thienyl-2)-6-H-1,3,4-thiadiazine (H-29) on the platelet aggregation has been studied in experiments on donor plasma in vitro. It is established that H-29 causes a decrease in the platelet interaction induced by ADP and arachidonic acid. The influence of H-29 on platelet aggregation was also studied in ex vivo experiments with intravenous and oral administration, and some parameters of plasmatic hemostasis were evaluated.

[Influence of new 1,3,4-thiadiazines on platelet aggregation in vitro and ex vivo].

The influence of new original 1,3,4-thiadiazines on the human platelet aggregation in vitro was studied. All substances inhibited the platelet aggregation induced by both ADP and arachidonic acid. 1,3,4-Thiadiazines L-19, H-30 and L-37 were the most effective inhibitors. Effect of the intravenous injection of L-19 in various doses on platelet aggregation and some parameters of plasmatic hemostasis were studied ex vivo.

[Correlation between structure and radioprotective activity (RPA) in thiazole derivatives]. / Vzaimosvaz struktura-radiozashchitnaia aktivnost (RZA) v riadu proizvodnykh tiazola.

The method of potential functions was used to predict adequately the radioprotective efficacy of thiazole derivative series, the geometrical indexes (1n A2 and A6) and anti-ion mass being applied as descriptors for organic and inorganic molecule parts respectively.

[Operational tests of "MOST", a new membrane oxygenator]. / Eksplutatatsionnye ispytaniia novogo membrannogo oksigenatora "MOST".

Functional and service characteristics of a Soviet membrane oxygenator are determined and compared with analogous foreign models. Results of hygienic examinations including medico-chemical and toxicological trials made it possible to evaluate oxygenator effects on a living organism.