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Ann Biol Clin (Paris) ; 70(3): 323-8, 2012.
Article in French | MEDLINE | ID: mdl-22565180

ABSTRACT

We describe the case of a serological reactivation in a Toxoplasma-seropositive subject, following a cardiac transplantation transmitting cysts contained in the myocardial tissue. In a context of acute graft rejection, primary chemoprophylaxis enables to avoid onset of opportunistic toxoplasmosis, emerging with immunodepletion performed by high-dose steroids. Then, we draw up a brief review of the bibliographical literature about pathophysiological mechanisms of toxoplasmic reactivation in heart transplants.


Subject(s)
Antibodies, Protozoan/immunology , Graft Rejection/etiology , Heart Transplantation/adverse effects , Heart Transplantation/immunology , Toxoplasmosis/diagnosis , Toxoplasmosis/etiology , Acute Disease , Antibodies, Protozoan/blood , Graft Rejection/immunology , Graft Rejection/parasitology , Heart Transplantation/physiology , Humans , Lymphocyte Activation/immunology , Lymphocyte Activation/physiology , Male , Middle Aged , Serology , Tissue Donors , Toxoplasma/immunology , Toxoplasma/isolation & purification , Toxoplasma/physiology , Toxoplasmosis/blood , Toxoplasmosis/immunology
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