Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 9 de 9
Filter
Add more filters










Database
Language
Publication year range
1.
JAMA Netw Open ; 4(8): e2121726, 2021 08 02.
Article in English | MEDLINE | ID: mdl-34424306

ABSTRACT

Importance: Prenatal smoking is a known modifiable risk factor for stillbirth; however, the contribution of prenatal drinking or the combination of smoking and drinking is uncertain. Objective: To examine whether prenatal exposure to alcohol and tobacco cigarettes is associated with the risk of stillbirth. Design, Setting, and Participants: The Safe Passage Study was a longitudinal, prospective cohort study with data collection conducted between August 1, 2007, and January 31, 2015. Pregnant women from Cape Town, South Africa, and the Northern Plains region of the US were recruited and followed up throughout pregnancy. Data analysis was performed from November 1, 2018, to November 20, 2020. Exposure: Maternal consumption of alcohol and tobacco cigarettes in the prenatal period. Main Outcomes and Measures: The main outcomes were stillbirth, defined as fetal death at 20 or more weeks' gestation, and late stillbirth, defined as fetal death at 28 or more weeks' gestation. Self-reported alcohol and tobacco cigarette consumption was captured at the recruitment interview and up to 3 scheduled visits during pregnancy. Participants were followed up during pregnancy to obtain delivery outcome. Results: Of 11663 pregnancies (mean [SD] gestational age at enrollment, 18.6 [6.6] weeks) in 8506 women for whom the pregnancy outcome was known by 20 weeks' gestation or later and who did not terminate their pregnancies, there were 145 stillbirths (12.4 per 1000 pregnancies) and 82 late stillbirths (7.1 per 1000 pregnancies). A total of 59% of pregnancies were in women from South Africa, 59% were in multiracial women, 23% were in White women, 17% were in American Indian women, and 0.9% were in women of other races. A total of 8% were older than 35 years. In 51% of pregnancies, women reported no alcohol or tobacco cigarette exposure (risk of stillbirth, 4 per 1000 pregnancies). After the first trimester, 18% drank and smoked (risk of stillbirth, 15 per 1000 births), 9% drank only (risk of stillbirth, 10 per 1000 pregnancies), and 22% smoked only (risk of stillbirth, 8 per 1000 pregnancies). Compared with the reference group (pregnancies not prenatally exposed or without any exposure after the first trimester), the adjusted relative risk of late stillbirth was 2.78 (98.3% CI, 1.12-6.67) for pregnancies prenatally exposed to drinking and smoking, 2.22 (98.3% CI, 0.78-6.18) for pregnancies prenatally exposed to drinking only after the first trimester, and 1.60 (98.3% CI, 0.64-3.98) for pregnancies prenatally exposed to smoking only after the first trimester. The adjusted relative risk for all stillbirths was 1.75 (98.3% CI, 0.96-3.18) for dual exposure, 1.26 (98.3% CI, 0.58-2.74) for drinking only, and 1.27 (98.3% CI, 0.69-2.35) for smoking only compared with the reference group. Conclusions and Relevance: These results suggest that combined drinking and smoking after the first trimester of pregnancy, compared with no exposure or quitting before the end of the first trimester, may be associated with a significantly increased risk of late stillbirth.


Subject(s)
Alcohol Drinking/adverse effects , American Indian or Alaska Native/statistics & numerical data , Pregnant Women , Prenatal Exposure Delayed Effects , Stillbirth , Tobacco Smoking/adverse effects , Adult , Female , Humans , Longitudinal Studies , North Dakota/epidemiology , Pregnancy , Pregnancy Outcome , Prevalence , Prospective Studies , Risk Factors , South Africa/epidemiology , South Dakota/epidemiology , Stillbirth/epidemiology
2.
J Insect Physiol ; 107: 34-40, 2018.
Article in English | MEDLINE | ID: mdl-29432766

ABSTRACT

Stable isotopes are valuable tools in physiological and ecological research, as they can be used to estimate diet, habitat use, and resource allocation. However, in most cases a priori knowledge of two key properties of stable isotopes is required, namely their rate of incorporation into the body (incorporation rate) and the change of isotope values between consumers and resources that arises during incorporation of the isotopes into the consumer's tissues (trophic discrimination). Previous studies have quantified these properties across species and tissue types, but little is known about how they vary with temperature, a key driver of many biological rates and times. Here, we explored for the first time how temperature affects both carbon incorporation rate and trophic discrimination via growth rates, using the domestic cricket, Acheta domesticus. We raised crickets at 16 °C, 21 °C, and 26 °C and showed that temperature increased carbon isotope incorporation rate, which was driven by both an increased growth rate and catabolism at higher temperatures. Trophic discrimination of carbon isotopes decreased at higher temperatures, which we attributed to either lower activation energies needed to synthesize non-essential amino acids at higher temperatures or the increased utilization of available resources of consumers at higher temperatures. Our results demonstrate that temperature is a key driver of both carbon isotope incorporation rate and trophic discrimination, via mechanisms that likely persist across all ectotherms. Experiments to determine incorporation rates and trophic discrimination factors in ectotherms must include temperature as a major factor, and natural variation in temperature might have significant effects on these isotopic properties that then can affect inferences made from isotope values.


Subject(s)
Carbon Isotopes/analysis , Carbon/metabolism , Gryllidae/physiology , Temperature , Animal Nutritional Physiological Phenomena , Animals , Diet , Gryllidae/growth & development , Nymph/growth & development , Nymph/physiology
3.
R Soc Open Sci ; 4(3): 170060, 2017 Mar.
Article in English | MEDLINE | ID: mdl-28405403

ABSTRACT

Intra-population niche differences in generalist foragers have captured the interest of ecologists, because such individuality can have important ecological and evolutionary implications. Few researchers have investigated how these differences affect the relationships among ecologically similar, sympatric species. Using stable isotopes, stomach contents, morphology and habitat preference, we examined niche partitioning within a group of five anurans and determined whether variation within species could facilitate resource partitioning. Species partitioned their niches by trophic level and by foraging habitat. However, there was considerable intraspecific variation in trophic level, with larger individuals generally feeding at higher trophic levels. For species at intermediate trophic levels, smaller individuals overlapped in trophic level with individuals of smaller species and larger individuals overlapped with the smallest individuals from larger species. Species varied in carbon isotopes; species with enriched carbon isotope ratios foraged farther from ponds, whereas species with depleted carbon isotope values foraged closer to ponds. Our study shows that these species partition their niches by feeding at different trophic levels and foraging at different distances from ponds. The intraspecific variation in trophic level decreased the number of individuals from each species that overlapped in trophic level with individuals from other species, which can facilitate species coexistence.

4.
Physiol Biochem Zool ; 88(5): 576-85, 2015.
Article in English | MEDLINE | ID: mdl-26658253

ABSTRACT

Stable isotope analysis is an increasingly useful ecological tool, but its accuracy depends on quantifying the tissue-specific trophic discrimination factors (TDFs) and isotopic incorporation rates for focal taxa. Despite the technique's ubiquity, most laboratory experiments determining TDFs and incorporation rates have focused on birds, mammals, and fish; we know little about terrestrial ectotherms, and amphibians in particular are understudied. In this study we used two controlled feeding experiments to determine carbon (δ(13)C) and nitrogen (δ(15)N) isotope TDFs for skin, whole blood, and bone collagen and incorporation rates for skin and whole blood in adult green frogs, Lithobates clamitans. The mean (±SD) TDFs for δ(13)C were 0.1‰ (±0.4‰) for skin, 0.5‰ (±0.5‰) for whole blood, and 1.6‰ (0.6‰) for bone collagen. The mean (±SD) TDFs for δ(15)N were 2.3‰ (±0.5‰) for skin, 2.3‰ (±0.4‰) for whole blood, and 3.1‰ (±0.6‰) for bone collagen. A combination of different isotopic incorporation models was best supported by our data. Carbon in skin was the only tissue in which incorporation was best explained by two compartments, which had half-lives of 89 and 8 d. The half-life of carbon in whole blood was 69 d. Half-lives for nitrogen were 75 d for skin and 71 d for whole blood. Our results help fill a taxonomic gap in our knowledge of stable isotope dynamics and provide ecologists with a method to measure anuran diets.


Subject(s)
Carbon/metabolism , Nitrogen/metabolism , Rana clamitans/metabolism , Animals , Bone and Bones/chemistry , Carbon Isotopes , Collagen/chemistry , Nitrogen Isotopes/metabolism , Skin/chemistry , Time Factors
5.
Biol Lett ; 10(4): 20140009, 2014.
Article in English | MEDLINE | ID: mdl-24759367

ABSTRACT

Few studies have examined how landmarks affect territories' fundamental characteristics. In this field study, we investigated effects of landmarks on territory size, shape and location in a cichlid fish (Amatitlania siquia). We provided cans as breeding sites and used plastic plants as landmarks. During 10 min trials, we recorded locations where residents chased intruders and used those locations to outline and measure the territory. In two experiments, we observed pairs without landmarks and with either a point landmark (one plant) or linear landmark (four plants) placed near the nest can. We alternated which trial occurred first and performed the second trial 24 h after the first. Territories were approximately round without landmarks or with a point landmark but were significantly more elongated when we added a linear landmark. Without landmarks, nests were centrally located; however, with any landmark, pairs set territory boundaries closer to the landmark and thus the nest. Territory size was significantly reduced in the presence of any landmark. This reduction suggests that a smaller territory with well-defined boundaries has greater benefits than a larger territory with less well-defined borders.


Subject(s)
Cichlids/physiology , Environment , Homing Behavior , Territoriality , Animals , Sexual Behavior, Animal
6.
Am J Med Genet A ; 164A(2): 495-9, 2014 Feb.
Article in English | MEDLINE | ID: mdl-24311370

ABSTRACT

Interstitial deletions of the long arm of chromosome 1 are rare and they are classified as proximal or intermediate. The intermediate interstitial deletions span 1q24-1q32. We describe a 6-year-old girl with multiple pituitary hormone deficiency, severe cognitive impairment, bilateral cleft lip and palate, midline facial capillary malformation, erythema of hands and feet and dysplastic cranial vessels, low anti-thrombin III activity, hemifacial overgrowth due to progressive infiltrating lipomatosis with bone overgrowth, marked vascular proliferation and erythema of hands and feet, and abnormal cranial vessels. The girl's karyotype showed an apparently de novo interstitial deletion 1q24.3q31.1, which was defined by array-CGH. The deleted region contains numerous genes, but only eight (CENPL, LHX4, LAMC1, LAMC2, PTGS2, ANGPTL1, TNN, and TNR) are good candidates to explain, at least partially, the phenotype of the proposita. We, therefore, discuss the involvement of these genes and the observed phenotype.


Subject(s)
Chromosome Deletion , Chromosomes, Human, Pair 1 , Face/abnormalities , Face/pathology , Lipomatosis/diagnosis , Lipomatosis/genetics , Pituitary Gland/abnormalities , Child, Preschool , Chromosome Banding , Comparative Genomic Hybridization , Facies , Female , Humans , Infant , Infant, Newborn , Magnetic Resonance Imaging , Phenotype
8.
J Am Diet Assoc ; 69(5): 506-10, 1976 Nov.
Article in English | MEDLINE | ID: mdl-988066

ABSTRACT

To identify the basis of growth failure, the background of preschool children whose growth fell below 97 per cent of their peers was compared with that of those who demonstrated a higher level of growth achievement. A questionnaire administered at the home of each child documented living conditions, health history, and other family characteristics. Families of the growth-retarded children had higher income, higher credit payments, and used higher dollar values of Food Stamps. A greater percentage of the growth-retarded children were low-birth-weight infants. However, neither low birth weight nor any other one factor consistently predicted poor growth achievement. The need for adequate growth standards to correctly diagnose achievement remains a primary need in the field of nutritional assessment.


Subject(s)
Growth Disorders/etiology , Adolescent , Adult , Age Factors , Birth Weight , Black People , Body Height , Body Weight , Child , Child Health Services , Child Rearing , Child, Preschool , Family Characteristics , Female , Growth Disorders/prevention & control , Humans , Infant , Infant, Low Birth Weight , Infant, Newborn , Male , Maternal Age , Michigan , Pregnancy , Socioeconomic Factors , White People
9.
Pediatrics ; 56(6): 1014-20, 1975 Dec.
Article in English | MEDLINE | ID: mdl-1196752

ABSTRACT

Measurements of height and weight were collected on 1,233 Black and white infants and children attending a Child Health Clinic in Washtenaw County, Michigan. Polynomial curves were fitted to each race and sex group and, from these, estimates were made of the 3rd, 50th, and 97th percentiles for height and weight. Blacks tended to be lighter and shorter than whites in early infancy. In the second year of life, Blacks tended to exceed whites in height and weight achievement. For infants and children in the 97th percentile this change in status occurred earlier. The differences in weight and height achievement were statistically significant in the two race groups, but not between sexes. The percentile estimates differed significantly from the percentiles of local as well as the "Iowa," "Harvard," and "Tanner" (United Kingdom) standards. Differences in the racial and environmental background of the clinic population and the samples used in the development of the national standards probably accounts for the variations in the percentile estimates. It is concluded that race- and sex-specific standards are required before growth achievements in infants and children can be properly evaluated.


Subject(s)
Child Development , Growth , Racial Groups , Body Height , Body Weight , Child , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Male , Michigan , Sex Factors , Statistics as Topic
SELECTION OF CITATIONS
SEARCH DETAIL
...