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Can Med Assoc J ; 101(12): 84-6, 1969 Dec 13.
Article in English | MEDLINE | ID: mdl-5364272

ABSTRACT

-A survey of vitamin A and carotene stores of Canadians at five major centres across Canada was completed. Vitamin A and carotene analyses were performed on approximately 100 human liver specimens obtained at necropsy from each location.Age influenced liver vitamin A stores. Children between 1 and 10 years of age had the highest vitamin A stores while a trend toward lower liver stores occurred between 20 and 40 years of age. Females had higher liver carotene stores than males but there was no such difference in vitamin A stores.SUBJECTS FROM ALL LOCATIONS WERE CLASSIFIED ACCORDING TO CAUSE OF DEATH: accidental, heart and coronary artery diseases, cancer, respiratory diseases and a miscellaneous disease group. The mean liver vitamin A and carotene stores of the accidental death group differed only from the cancer group. In contrast to the disease groups, no case with undetectable vitamin A was found in the accidental death group.The mean vitamin A and carotene stores of Vancouver subjects were generally higher than those for the other locations. Montreal showed more values in the 0-40 mug. per g. range than the other locations. Vancouver had the least number (15%), with Halifax, Ottawa and Winnipeg being intermediate (32%). These data suggest the need for improved nutrition, prophylactic treatment in disease states and the need for further research on the utilization and metabolism of vitamin A.


Subject(s)
Carotenoids/metabolism , Vitamin A/metabolism , Accidents , Adolescent , Adult , Age Factors , Aged , Autopsy , Canada , Child , Child, Preschool , Coronary Disease/metabolism , Female , Heart Diseases/metabolism , Humans , Infant , Infant, Newborn , Liver/metabolism , Male , Middle Aged , Neoplasms/metabolism , Nutrition Surveys , Respiratory Tract Diseases/metabolism , Sex Factors , Vitamin A Deficiency/epidemiology
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