ABSTRACT
During the liquidation of consequences of chemical accidents the main task is minimization o the population losses and the provision of effective medical care to. the victims. Training experience related to chemical accidents, shows the need for constant readiness of health facilities in the area of the chemical industry accommodation, planning of the medical forces and resources reserve. The most important elements of medical care in chemical accidents are affected sorting, intensive therapy and reanimation in cases of severe injuries, the organization of the observation of persons with initial minor manifestations of intoxication. Emergency assistance should be provided in full volume as soon as possible. It .is essential to provide enough oxygen and required. drugs (hormonal drugs, diuretics, antibiotics, anticonvulsants, analgesics, and others). Multistage evacuation should be excluded and should be:done the planned training within the medical service stuff with toxicological profile.
Subject(s)
Chemical Hazard Release , Disaster Medicine , Disaster Planning , Education, Medical, Continuing , Transportation , Disaster Medicine/education , Disaster Medicine/methods , Disaster Medicine/organization & administration , Disaster Medicine/standards , Disaster Planning/methods , Disaster Planning/organization & administration , Disaster Planning/standards , Humans , Transportation/methods , Transportation/standardsABSTRACT
Aminostigmin, a novel reversible inhibitor of cholinesterase developed in Russia, has been tried in management of poisoning with cholinolytyics, antihistamine drugs, tricycle antidepressants and derivatives of 1,4-benzodiazepine. The treatment of 144 patients with aminostigmin and 20 patients with galantamin showed close to similar efficacy of these drugs. The scheme of aminostigmin administration is proposed warranting fast relief of cholinolytic syndrome in subjects poisoned with cholinolytics, antihistamine drugs and antidepressants. Benzodiazepines poisoning was unresponsive to aminostigmin. Rare side effects were caused by overdose. Aminostigmin is an effective antidote in cholinolytic poisoning.
Subject(s)
Antidotes/therapeutic use , Carbamates , Cholinesterase Inhibitors/therapeutic use , Poisoning/drug therapy , Pyridines , Adolescent , Adult , Female , Galantamine/therapeutic use , Humans , Male , Middle Aged , Pyridostigmine Bromide/analogs & derivatives , Treatment OutcomeSubject(s)
Bone Marrow/drug effects , Fluorouracil/toxicity , Animals , Bone Marrow/radiation effects , Bone Marrow Cells , Cell Division/drug effects , Cell Division/radiation effects , DNA/drug effects , DNA/radiation effects , Dose-Response Relationship, Drug , Dose-Response Relationship, Radiation , Flow Cytometry/methods , Male , Mice , Mitosis/drug effects , Mitosis/radiation effects , Rats , Time FactorsABSTRACT
Phytohemagglutinin (PHA)-effected lymphocyte blastogenesis test (LBGT) in culture has been assessed by flow cytofluorometry in 63 normal subjects and in 160 patients suffering from various pulmonary diseases. An algorithm for the estimation of cellular distribution in accordance with the mitotic cycle stages is suggested, and a computer program for the analysis of the results, based on the mitotic cycle stages, has been compiled. The lymphocyte proliferative activities have been estimated with various PHA doses. The findings have been in good correlation with the results of radionuclide studies (3H thymidine label). The described approach to LBGT assessment yields reliable results and may be used in diagnostic studies.
