ABSTRACT
We present a case of a 40-year-old Spanish man with cardiac amyloidosis in which a Tc-99m-3,3-diphosphono-1,2-propanodicarboxylic acid (Tc-99m-DPD) scintigraphy was strongly suggestive of cardiac amyloidosis by transthyretin (ATTR) but endomyocardial biopsy (EB) analyzed by immunohistochemistry demonstrated a light chain amyloidosis (AL). Even though the Tc-99m-DPD has proven in different published papers that has high sensibility and specificity for differentiating AL and ATTR cardiac amyloidosis, we present an unusual case of an AL cardiac amyloidosis with a Perugini grade 3 on the scintigraphy. Diagnostic approach of cardiac amyloidosis following consensus documents is discussed to avoid diagnostic mistakes based on imaging techniques.
Subject(s)
Diphosphonates/pharmacokinetics , Heart Diseases/diagnostic imaging , Immunoglobulin Light-chain Amyloidosis/diagnostic imaging , Organotechnetium Compounds/pharmacokinetics , Radionuclide Imaging , Radiopharmaceuticals/pharmacokinetics , Adult , Echocardiography , Electrocardiography , Heart Diseases/metabolism , Humans , Immunoglobulin Light-chain Amyloidosis/metabolism , MaleABSTRACT
Dermatologic findings manifest in childhood, but the disease progresses to multiple organ systems. Here's how to proceed if you diagnose this in your patient.
