ABSTRACT
AIM: To assess diagnostic and prognostic role of CPK-MBmass and troponin I(TnI) in patients with acute coronary syndrome without persistent ST segment elevation (ACS). MATERIAL AND METHODS: Standard laboratory and device tests, measurements of CPK-MBmass and TnI levels at admission, 12 and 24 hours after hospitalization were performed in 51 ACS patients (33 men, 18 women, mean age 63 +/- 8.2 years). Early and late (1 month and 6, 12 months after hospitalization, respectively) complications were studied. RESULTS: The analysis of the immediate outcomes has revealed that treatment brought about stabilization of the condition in 45 (88.2%) patients, 6 patients had myocardial infarction within a month since the disease onset, one patient died. Late MI developed in 6 patients. For 6 months 2 more patients died. One patient died in the following 6 months. Thus ACS points to adverse 1-month prognosis in 12 and 1-year prognosis in 23.5% patients. TnI levels and CPK-MBmass are sensitive and specific for an adverse outcome in 91.7 and 100%, 82 and 89.7%, respectively. A predictive value for positive outcomes was 61.1 and 75%, respectively, for negative results 96.9 and 100%, respectively. CONCLUSION: Estimation of CPK-MBmass and TnI is essential in diagnosis of non-Q-wave MI and is predictable in relation to both short- and long-term prognosis.
