ABSTRACT
The influence of silistrong on the activity of erythrocyte cytoplasmatic dehydrogenases and also purified glyceraldehyde-3-phosphate dehydrogenase (GAPH) was studied. Silistrong and its biologically active components (ethanol and silimarine) were found to activate GAPDH, lactate dehydrogenase (LDH), alpha-glycerophosphate dehydrogenase (GPDH) both in lysates of erythrocytes and in isolated GAPDH. The compounds studied are able to protect these enzymes and also to restore their activity of enzymes modified by hydrogen peroxide. Maximal activity is a characteristic of silistrong.
Subject(s)
Cytoplasm/enzymology , Ethanol/metabolism , Hydrogen Peroxide/metabolism , Oxidoreductases/metabolism , Silymarin/metabolism , Animals , Antioxidants/metabolism , Antioxidants/pharmacology , Central Nervous System Depressants/metabolism , Central Nervous System Depressants/pharmacology , Enzyme Activation/drug effects , Erythrocytes/enzymology , Ethanol/pharmacology , Hydrogen Peroxide/pharmacology , Oxidants/metabolism , Oxidants/pharmacology , Rabbits , Silymarin/pharmacologyABSTRACT
Decrease of adaptable opportunities at children from ecologically unsuccessful region with a defective diet is marked. Attributes deceleration, tendencies to leucopenia, lumphopenia, monocytopenia, reduction of the maintenance of hemoglobin are revealed. Change of structurally functional parameters of erithrocyto's membranes, infringement of a parity about and antioxidant processes is typical. Decrease of quality of health causes necessity of realization of improving actions.
Subject(s)
Adaptation, Physiological , Child Development , Child Nutritional Physiological Phenomena , Environment , Alcohol Drinking , Body Height , Body Weight , Case-Control Studies , Catalase/blood , Child , Ecology , Environmental Exposure , Erythrocyte Membrane/ultrastructure , Female , Hemoglobins/analysis , Humans , Leukopenia/pathology , Lymphopenia/pathology , Male , Parents , Pregnancy , Pregnancy Complications/epidemiology , Reference Values , Superoxide Dismutase/blood , Urban HealthABSTRACT
In article is discussed the information on properties of alcohol, distribution in organism, systems of oxidation, elimination, biological activity of ethanol and acetaldehyde, mechanisms of damaging action of an alcoholic intoxication.
Subject(s)
Ethanol/metabolism , Ethanol/pharmacology , Alcoholic Intoxication/etiology , Ethanol/chemistry , Ethanol/toxicity , HumansABSTRACT
Minimal brain dysfunctions in children with various perinatal complications are accompanied by metabolic imbalance manifested by decreased total protein content, the tendency to reduced triglycerides, increased cholesterol concentrations in the oral fluid, the trend to hypoproteinaemia, hypoglycaemia, hypotriglyceridaemia. The most significant changes in the redox systems alpha-ketoglutarate-glutamate, oxaloacetate-malate, pyruvate-lactate, dioxyacetone phosphate-alpha-glycerophosphate in biological fluids were revealed in cases of antenatal alcoholisation. A certain correlation was found between anemia in pregnant women and hypothyroidal background in children. In addition, a high level of free and total thyroxine, that of total triiodthyronine were found in the oral fluid. Hypophysis--thyroid dysregulation in children with minimal brain dysfunction associated with gestosis in their mothers during pregnancy, was manifested by decreased content of total and free T4 and T3 in blood serum and increased level of the thyroid-stimulating hormone.
Subject(s)
Attention Deficit Disorder with Hyperactivity/metabolism , Saliva/chemistry , Saliva/metabolism , Thyroid Hormones/analysis , Attention Deficit Disorder with Hyperactivity/blood , Carboxylic Acids/analysis , Carboxylic Acids/blood , Child , Child, Preschool , Female , Glucose/analysis , Humans , Lipids/analysis , Lipids/blood , Oxidation-Reduction , Pregnancy , Pregnancy Complications , Proteins/analysis , Thyroid Hormones/bloodABSTRACT
The effect of intravenous administration of lactate dehydrogenase (5000 E/kg) on some metabolic parameters was investigated. The hyperenzymemia was accompanied by changes of metabolite content (glutamate, 2-oxoglutarate, lactate, dihydroxyacetone phosphate) and enzyme activities (aldolase, lactate dehydrogenase, transaminase) in heart, liver and skeletal muscles. Intravenously administered tritiated lactate dehydrogenase was preferentially found in skeletal muscles, liver, kidneys and some other organs.
