[Treatment of endometritis and salpingo-oophoritis monitored by the antilysozyme activity of the agents]. / Lechenie endometrita i sal'pingooforita pod kontrolem antilizotsimnoiaktivnosti vozbuditelia.

The authors suggest new methods for the choice of drugs and physiotherapeutic modalities for the treatment of female genital inflammations, based on the suppression of the agents' antilysozymic activities, factors of the agent intracellular persistence. Clinical trials of these methods in 91 patients have shown their high efficacy: the incidence of complete remissions has increased by 60.7%, incidence of disease recurrences reduced by 53%, and remission periods in chronic patients were prolonged by 2.5-3 times (from 0.5-1 year to 2.5-3 years).

[Experimental and clinical studies of drug regulation of the anti-lysozyme activity of microorganisms causing opportunistic infections]. / Eksperimental'no-klinicheskoe izuchenie lekarstvennoi reguliatsii antilizotsimnoi aktivnosti vozbuditelei opportunisticheskikh infektsii.

Experimental materials on choosing antibiotics for etiotropic therapy of opportunistic infections with an account of the regulating effect of the drugs on the ++anti-lysozyme activity of pathogens (the factor of intracellular parasitism) are presented. The in vitro data were applied to the clinical trials in 30 patients with chronic and acute pyelonephritis of the Proteus etiology and to 25 patients with chronic inflammatory diseases of Staphylococcus etiology. It was shown that the use of the antibiotics which lowered the ++anti-lysozyme activity of microorganisms promoted a more rapid disappearance of the disease clinical signs, increased 2- to 3-fold the terms of the remission and resulted in an increase in the number of the persons with complete remission (54.5 to 63.6 per cent) as compared to the use of the drugs which stimulated the pathogen property or were indifferent to it.

[Bacterial antilysozyme activity and its regulation by antibiotics]. / Antilizotsimnaia aktivnost' bakterii i ee reguliatsiia antibiotikami.

The effect of subinhibitory doses of 25 antibiotics on the antilysozyme property of enterobacteria considered as a marker of their persistence was studied. This provided dividing the antibiotics into 3 groups: antibiotics increasing the bacterial capacity for lysozyme degradation, antibiotics indifferent with respect to this property and antibiotics decreasing it. Decreasing of the Salmonella antilysozyme activity by gentamicin under experimental conditions promoted suppression of the bacteria parasitism in Hep-2 cells. Clinical and laboratory studies on the effect of antibiotic therapy under the control of the time course of the antilysozyme property of the pathogen in patients with acute dysentery, pyelonephritis and inflammatory processes in the female genitalia showed that the use of the antibiotics increasing this property in the pathogen was not advisable which was confirmed by the absence of significant clinical improvement in the patients and necessity of prolonging the sanative period.