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1.
Geburtshilfe Frauenheilkd ; 83(4): 410-436, 2023 Apr.
Article in English | MEDLINE | ID: mdl-37034416

ABSTRACT

Aim This completely revised interdisciplinary S2k-guideline on the diagnosis, therapy, and follow-up care of female patients with urinary incontinence (AWMF registry number: 015-091) was published in December 2021. This guideline combines and summarizes earlier guidelines such as "Female stress urinary incontinence," "Female urge incontinence" and "Use of Ultrasonography in Urogynecological Diagnostics" for the first time. The guideline was coordinated by the German Society for Gynecology and Obstetrics (Deutsche Gesellschaft für Gynäkologie und Geburtshilfe, DGGG) and the Working Group for Urogynecology and Plastic Pelvic Floor Reconstruction (Arbeitsgemeinschaft für Urogynäkologie und plastische Beckenbodenrekonstruktion e. V., AGUB). Methods This S2k-guideline was developed using a structured consensus process involving representative members from different medical specialties and was commissioned by the Guidelines Commission of the DGGG, OEGGG and SGGG. The guideline is based on the current version of the guideline "Urinary Incontinence in Adults" published by the European Association of Urology (EAU). Country-specific items associated with the respective healthcare systems in Germany, Austria and Switzerland were also incorporated. Recommendations The short version of this guideline consists of recommendations and statements on the surgical treatment of female patients with stress urinary incontinence and urge incontinence. Specific solutions for the diagnostic workup and treatment of uncomplicated and complicated urinary incontinence are discussed. The diagnostics and surgical treatment of iatrogenic urogenital fistula are presented.

2.
Geburtshilfe Frauenheilkd ; 83(4): 377-409, 2023 Apr.
Article in English | MEDLINE | ID: mdl-37034417

ABSTRACT

Aim This completely revised interdisciplinary S2k-guideline on the diagnosis, therapy, and follow-up care of female patients with urinary incontinence (AWMF registry number: 015-091) was published in December 2021. This guideline combines and summarizes earlier guidelines such as "Female stress urinary incontinence," "Female urge incontinence" and "Use of Ultrasonography in Urogynecological Diagnostics" for the first time. The guideline was coordinated by the German Society for Gynecology and Obstetrics (Deutsche Gesellschaft für Gynäkologie und Geburtshilfe, DGGG) and the Working Group for Urogynecology and Plastic Pelvic Floor Reconstruction (Arbeitsgemeinschaft für Urogynäkologie und plastische Beckenbodenrekonstruktion e. V., AGUB). Methods This S2k-guideline was developed using a structured consensus process involving representative members from different medical specialties and was commissioned by the Guidelines Commission of the DGGG, OEGGG and SGGG. The guideline is based on the current version of the guideline "Urinary Incontinence in Adults" published by the European Association of Urology (EAU). Country-specific items associated with the respective healthcare systems in Germany, Austria and Switzerland were also incorporated. Recommendations The short version of this guideline consists of recommendations and statements on the epidemiology, etiology, classification, symptoms, diagnostics, and treatment of female patients with urinary incontinence. Specific solutions for the diagnostic workup and appropriate conservative and medical therapies for uncomplicated and complication urinary incontinence are discussed.

3.
Dtsch Arztebl Int ; 113(12): 212, 2016 03 25.
Article in English | MEDLINE | ID: mdl-27118723
4.
Dtsch Arztebl Int ; 112(33-34): 564-74, 2015 Aug 17.
Article in English | MEDLINE | ID: mdl-26356560

ABSTRACT

BACKGROUND: 25% of all women report involuntary loss of urine, and 7% may require treatment. METHODS: This review is based on a selection of pertinent literature, including guidelines and Cochrane reviews. RESULTS: The assessment of pelvic floor dysfunction in women begins with a basic evaluation that is followed by special diagnostic tests if indicated. The physician taking the clinical history should inquire about the patient's behavior, personality, social and other stressors, and eating and drinking habits, as well as any mental disorders that may be present, including anxiety disorders, depression, somatization disorders, and disorders of adaptation. Conservative treatment consists mainly of lifestyle changes, physiotherapy, and medication. Stress incontinence is most commonly treated with pelvic floor exercises, with a documented success rate of 56.1% vs. 6% without such treatment (relative risk 8.38, 95% confidence interval 3.67-19.07). If incontinence persists, surgery may be indicated ( implantation of suburethral tension-free slings, or colposuspension). Feedback and biofeedback training can be used to treat an overactive bladder. If these techniques and drug therapy are unsuccessful, botulinum toxin injections can be considered. CONCLUSION: Well-validated treatments for pelvic floor dysfunction are available. Psychosomatic factors must be taken into account and can have a major effect on treatment outcomes.


Subject(s)
Pelvic Floor Disorders/diagnosis , Pelvic Floor Disorders/therapy , Urinary Incontinence, Stress/diagnosis , Urinary Incontinence, Stress/etiology , Urinary Incontinence, Stress/prevention & control , Biofeedback, Psychology/methods , Combined Modality Therapy/methods , Evidence-Based Medicine , Exercise Therapy/methods , Female , Female Urogenital Diseases , Gynecologic Surgical Procedures/methods , Humans , Pelvic Floor Disorders/complications , Suburethral Slings , Treatment Outcome , Women's Health
5.
Int Urogynecol J ; 25(8): 1023-30, 2014 Aug.
Article in English | MEDLINE | ID: mdl-24819327

ABSTRACT

BACKGROUND: We conducted a prospective randomized controlled noninferiority trial to compare objective and subjective outcomes of retropubic tension-free vaginal tape (TVT) with those of transobturator tape (TVT-O) as primary treatment for stress urinary incontinence (SUI) in women. STUDY DESIGN: The study was conducted at 25 gynecology units in Austria and Germany; regional and academic hospitals participated. A total of 569 patients were randomly assigned to undergo TVT or TVT-O. RESULTS: A total of 480 patients (85%) were examined at 3 months. A negative cough stress test with stable cystometry to 300 ml was seen in 87% of patients after TVT and in 84% after TVT-O; 64% and 59% of patients, respectively, reported no pad use, and 88% of patients in both groups considered themselves much or very much better on the Patient Global Impression of Improvement (PGI-I) scale. Quality of life (QoL) as assessed with the SF-12 Health Survey, Kings' Health Questionnaire, (KHQ), and EuroQol-5D (EQ-5D) was significantly improved in both arms, with no differences between arms. There were no significant differences in postoperative pain or complications. CONCLUSIONS: Results of this trial demonstrate noninferiority between TVT and TVT-O with regard to postoperative continence and QoL and suggest little difference in perioperative problems (ClinicalTrials.gov NCT 00441454).


Subject(s)
Suburethral Slings , Urinary Incontinence, Stress/surgery , Absorbent Pads , Aged , Female , Follow-Up Studies , Humans , Middle Aged , Prospective Studies , Quality of Life , Suburethral Slings/adverse effects , Surveys and Questionnaires , Treatment Outcome
6.
Int Urogynecol J ; 22(2): 229-32, 2011 Feb.
Article in English | MEDLINE | ID: mdl-20838986

ABSTRACT

INTRODUCTION AND HYPOTHESIS: A dipstick test is recommended to screen for urinary tract infection in patients with overactive bladder (OAB). It was the aim of this study to test if a dipstick test is sufficient to identify patients with urinary tract infection attending a urological private practice because of OAB. METHODS: All patients who attended the practice because of OAB symptoms were routinely catheterized; a urine specimen was tested with dipstick, the spun sediment was examined microscopically, and the specimen was sent for microbiological examination. RESULTS: Two thousand two hundred fifty-two patients were examined. Of 1,754 patients with negative dipstick screening, 353 patients (20.1%) had growth of ≥10(3) colony forming units. The dipstick test had a sensitivity of 0.442 and a specificity of 0.865 for the correct identification of urinary tract infection. CONCLUSIONS: Dipstick screening is not sufficient to identify patients with urinary tract infection and symptoms of OAB.


Subject(s)
Reagent Strips , Urinary Bladder, Overactive/complications , Urinary Tract Infections/diagnosis , Female , Humans , Predictive Value of Tests , Urinary Tract Infections/complications
7.
Arch Gynecol Obstet ; 284(3): 663-6, 2011 Sep.
Article in English | MEDLINE | ID: mdl-21046135

ABSTRACT

PURPOSE: To evaluate how many patients with overactive bladder still take their prescribed medication at least 12 months later and to find out the reasons for discontinuation of the therapy. METHODS: Two hundred and ten patients who had received a prescription for anticholinergic medication were contacted by telephone 12-46 months later. RESULTS: Out of 210 eligible patients 132 (63%) could be contacted and gave consent to participate in the study. 38% of them still took their medication after at least 12 months. 17% were continent or much improved, 13% a little improved, 8% were not improved, although still taking their medication. 62% did not take the original medication any more. 10% had never started with the medication, 42% took the medication for 3 months and 8% for 4-12 months. 25% had changed to another anticholinergic drug. CONCLUSION: Anticholinergic therapy is often discontinued by patients and doctors. Patients with OAB therefore need counselling and follow-up in the long term to make sure that alternative treatment is offered if anticholinergic treatment does not work.


Subject(s)
Cholinergic Antagonists/therapeutic use , Medication Adherence/statistics & numerical data , Urinary Bladder, Overactive/drug therapy , Adult , Aged , Aged, 80 and over , Cholinergic Antagonists/adverse effects , Female , Follow-Up Studies , Humans , Interviews as Topic , Middle Aged , Muscarinic Antagonists/adverse effects , Muscarinic Antagonists/therapeutic use , Parasympatholytics/adverse effects , Parasympatholytics/therapeutic use , Treatment Failure , Young Adult
8.
Gynecol Obstet Invest ; 68(2): 82-7, 2009.
Article in English | MEDLINE | ID: mdl-19420960

ABSTRACT

BACKGROUND/AIMS: The aim of our study was to evaluate the prevalence of abuse among pregnant women in Germany attending our antenatal outpatient clinic and to observe whether a history of abuse had consequences for women's feelings about their pregnancy. METHODS: 455 women between the 35th and 42nd weeks of gestational age were included and were asked to fill out an anonymous questionnaire concerning their pregnancy, their actual psychological state, and their history of physical/sexual abuse. 600 questionnaires were distributed (return rate 75.8%), 70 women (10.4%) were excluded because of male companionship to ensure their safety in case that they were currently in an abusive relationship with the attending man. RESULTS: 88 women (19.3%) reported a history of sexual and/or physical abuse. Pregnant women after physical and/or sexual abuse significantly more frequently associate negative feelings with their pregnancy than nonabused women. The Hospital Anxiety Depression Scale (HADS) and the SCL-K-9 demonstrated significantly more negative feelings of depression and anxiety, strain, loneliness and less expectation of happiness for their future in abused women. CONCLUSION: Physical and sexual abuse are relevant problems among women in obstetric care that may complicate their pregnancies and make them feel more depressive.


Subject(s)
Battered Women/statistics & numerical data , Pregnancy/psychology , Sex Offenses , Anxiety/psychology , Battered Women/psychology , Depression/epidemiology , Depression/psychology , Family/psychology , Female , Germany/epidemiology , Humans , Male , Medical History Taking , Parents/psychology , Prenatal Care , Sex Offenses/psychology , Sex Offenses/statistics & numerical data , Surveys and Questionnaires
9.
Eur J Obstet Gynecol Reprod Biol ; 140(1): 118-23, 2008 Sep.
Article in English | MEDLINE | ID: mdl-18617318

ABSTRACT

OBJECTIVE: A survey was conducted to evaluate the urogynecology training of German gynecologists and the diagnostic tests and therapeutic options offered to women with incontinence or prolapse in hospital departments and private practices. STUDY DESIGN: Questionnaires were mailed to 3000 gynecologists in private practice and to 500 consultants in gynecology departments. The questionnaire included items on urogynecological training, diagnostic workup as well as conservative and surgical treatment options. RESULTS: The response rate was 16.8% with 589 of the 3500 questionnaires being returned. Less than one third of the respondents (28.6%) regard their training in urogynecology as good, 41% rate their training as moderate and 30.4% state that their urogynecology training during residency was inadequate. Male physicians significantly more often consider themselves well trained than women (p=.00006). The majority of gynecologists in private practice (74.7%) refer patients to a gynecological clinic for assessment of urogynecologic symptoms, 37.7% refer their patients to urologists in private practice, 10.4% to other gynecologists in private practice, and 10.4% to a urological clinic (percentages add up to more than 100% because multiple answers were allowed). Among the gynecologists who offer surgery, 81.2% perform retropubic TVT-operation and 80.1% colposuspension. Seventy-seven percentage of the gynecologists in private practice who do operations on an inpatient basis still perform anterior colporrhaphy to treat stress urinary incontinence compared to 62% of consultants in gynecological clinics (p<.05). CONCLUSION: One third of German gynecologists consider themselves inadequately trained in urogynecology. The results of our survey show that there is a need for improved general training during residency and for subspecialist training.


Subject(s)
Cystocele/surgery , Gynecology/education , Referral and Consultation , Urinary Incontinence/surgery , Urologic Surgical Procedures/education , Uterine Prolapse/surgery , Clinical Competence , Data Collection , Female , Germany , Humans , Male , Physicians , Self-Assessment , Sex Factors , Suburethral Slings/statistics & numerical data , Urology/education
10.
Int Urogynecol J Pelvic Floor Dysfunct ; 18(4): 449-53, 2007 Apr.
Article in English | MEDLINE | ID: mdl-16917674

ABSTRACT

The known sequelae of sexual abuse include acute and chronic injury. The purpose of this study was to evaluate the association of overactive bladder symptoms (OABs) with a history of physical or sexual abuse. Two hundred and forty-three women who attended the gynaecological out-patient clinic or the urogynaecological clinic were recruited for our study. Based on their clinical examination, they were assigned to three groups of patients with either OAB or with stress urinary incontinence (SUI) without concomitant urgency symptoms (SUI), or without history of incontinence (control group). Afterwards, they completed an anonymous questionnaire about bladder function and physical/sexual violence. Significantly more women (30.6%, 26/85) with OAB had previously been physically or sexually abused than women with SUI (17.8%, 18/101) and of the control group (17.5%, 10/57). Our study showed that significantly more women with OAB report physical and sexual abuse than subjects with stress incontinence or no urinary complaints. Women with stress incontinence had the same rate of self-reported physical/sexual abuse as continent controls.


Subject(s)
Domestic Violence/statistics & numerical data , Sex Offenses/statistics & numerical data , Urinary Bladder, Overactive/complications , Urinary Incontinence, Stress/complications , Adult , Aged , Case-Control Studies , Female , Humans , Middle Aged , Risk Factors , Socioeconomic Factors , Surveys and Questionnaires
11.
Neurourol Urodyn ; 24(1): 44-50, 2005.
Article in English | MEDLINE | ID: mdl-15573382

ABSTRACT

AIMS: To compare the histomorphology of pelvic floor specimens of 94 female cadavers, ten male cadavers, and 24 female symptomatic patients who underwent pelvic floor surgery, and to evaluate the association of age, parity, and sex to myogenic and/or neurogenic changes to the levator ani muscle (LAM). METHODS: The pelvic floor was biopsied at the pubococcygeus, the iliococcygeus and the coccygeus muscle. After staining, signs for myogenic/neurogenic changes to the muscle were evaluated (fibrosis, variation in fiber diameter, centralization of nuclei, small angulated fibers, and type grouping). To identify the intact neuromuscular junction stainings with NCAM (neuronal cell adhesion molecule) and acetylcholinesterase (ACE) were used. RESULTS: A significant influence of age and parity on the histomorphological criteria of myogenic cell-damage was shown in this study. Although these criteria were found even in young nulliparous women, there was a significant increase in older or parous women with at least one vaginal delivery. We failed to demonstrate significant changes between the nulliparous LAM, the male LAM, and the LAM from women with prolapse and incontinence. None of the specimen showed any obvious evidence of neuropathy. CONCLUSIONS: We have evaluated histological criteria adapted from the examination of limb muscles in the LAM of nulliparous young women. "Myogenic changes" seem to be a normal finding in the LAM. The increase of these changes with aging and parity points to mechanical stress to the LAM as the most plausible causative factor. We propose that further studies using histomorphological techniques of the pelvic floor muscle in nulliparous and parous women should clarify the potential role of our histological findings.


Subject(s)
Aging/pathology , Delivery, Obstetric , Pelvic Floor/pathology , Vagina/pathology , Adolescent , Adult , Connective Tissue/innervation , Connective Tissue/pathology , Female , Humans , Male , Middle Aged , Muscle, Skeletal/innervation , Muscle, Skeletal/pathology , Parity , Pelvic Floor/innervation , Peripheral Nerves/pathology , Sex Factors , Vagina/innervation
12.
Eur J Obstet Gynecol Reprod Biol ; 110(1): 39-42, 2003 Sep 10.
Article in English | MEDLINE | ID: mdl-12932869

ABSTRACT

OBJECTIVES: To evaluate urinary and fecal incontinence symptoms, and occult anal sphincter defects in women after vacuum and spontaneous vaginal delivery. STUDY DESIGN: In a case-control study, 50 primiparous women delivered by vacuum extraction were compared to 50 women delivered spontaneously. Urinary and anal incontinence symptoms, pelvic floor muscle strength and sphincter defects on endoanal ultrasound were evaluated 6-24 weeks postpartum. RESULTS: New anal incontinence symptoms after childbirth were found in 30% of the vacuum group compared to 34% of the controls, new urinary incontinence symptoms in 28 and 42%, respectively (not significant). After excluding Grade III perineal tear, sonographic sphincter defects were found in 11 (27.5%) after vacuum delivery compared to 4 (10%) after spontaneous delivery (P<0.05, chi(2)-test). CONCLUSION: Anal and urinary incontinence symptoms are frequent after vaginal delivery. Vacuum delivery causes more sonographic sphincter defects but appears to cause no more harm to pelvic floor function than spontaneous vaginal delivery.


Subject(s)
Fecal Incontinence/etiology , Urinary Incontinence/etiology , Vacuum Extraction, Obstetrical/adverse effects , Adult , Case-Control Studies , Episiotomy/statistics & numerical data , Fecal Incontinence/epidemiology , Fecal Incontinence/therapy , Female , Humans , Parity , Perineum/injuries , Pregnancy , Urinary Incontinence/epidemiology , Urinary Incontinence/therapy , Uterine Prolapse/epidemiology
13.
Obstet Gynecol ; 101(1): 103-8, 2003 Jan.
Article in English | MEDLINE | ID: mdl-12517653

ABSTRACT

OBJECTIVE: To estimate the prevalence of sexual abuse among patients seen for gynecologic care in Germany. METHODS: A short anonymous questionnaire was distributed to 1157 women attending a gynecologic outpatient clinic at a large urban teaching hospital. Data collected using the questionnaire included patient characteristics, sexual abuse history, and screening practices. Women who reported that they had been abused were asked if they had ever discussed the issue with their gynecologist. RESULTS: A total of 1075 questionnaires were returned, for a response rate of 92.9%. Almost half (n = 479 [44.6%]) of the women surveyed reported that they had been the subject of unwanted sexual attention. One fifth (n = 216 [20.1%]) had been forced to engage in sexual activities: 6.8% in childhood, 10.3% during adolescence, 6.4% as an adult, and 3.5% across more than one stage. Thirteen women (6%) reported having discussed the abuse with their gynecologist. Sixty-six (30.5%) were too afraid to raise the issue, and 119 (55.1%) stated it was not relevant to their care. Only one woman (0.5%) reported that her gynecologist had asked about sexual abuse. CONCLUSION: Despite the high prevalence of sexual abuse among women seeking gynecologic care, routine screening does not appear to be part of standardized practice.


Subject(s)
Sex Offenses/statistics & numerical data , Adolescent , Adult , Child , Child Abuse, Sexual/statistics & numerical data , Female , Germany/epidemiology , Humans , Outpatient Clinics, Hospital , Physician-Patient Relations , Practice Patterns, Physicians'
14.
Eur J Obstet Gynecol Reprod Biol ; 105(2): 181-5, 2002 Nov 15.
Article in English | MEDLINE | ID: mdl-12381484

ABSTRACT

OBJECTIVE: To evaluate the long-term efficacy of pelvic floor re-education (PFR) with EMG-controlled biofeedback in the treatment of female genuine stress or mixed incontinence. STUDY DESIGN: Between 1995 and 1998, 36 women completed a pelvic floor muscle training with a biofeedback device for 3-6 months. A mean of 26 months later, a follow-up examination was performed. RESULTS: The prevalence of lower urinary tract symptoms decreased significantly immediately after the training but increased again at the long-term follow-up. Levator ani muscle strength improved after the treatment and remained significantly better for long-term follow-up. Immediately after the program, 25 (70%) women reported cure or improvement of stress incontinence. At the long-term follow-up, 17 (47%) reported the same result. CONCLUSIONS: About half of the patients after PFR with biofeedback are still improved or cured after 26 months. Women should be counseled about the long-term efficacy and about the necessity of maintaining training.


Subject(s)
Electromyography , Exercise , Feedback , Pelvic Floor/physiopathology , Urinary Incontinence/therapy , Adult , Aged , Aged, 80 and over , Female , Follow-Up Studies , Humans , Middle Aged , Recurrence , Treatment Outcome , Urinary Incontinence/physiopathology , Urinary Incontinence, Stress/physiopathology , Urinary Incontinence, Stress/therapy
15.
Acta Obstet Gynecol Scand ; 81(3): 214-21, 2002 Mar.
Article in English | MEDLINE | ID: mdl-11966477

ABSTRACT

OBJECTIVE: While obstetrical management has changed significantly over years, the optimal duration of the second stage of labor still remains to be defined. The purpose of this study was to evaluate the effect of the duration of labor on fetal distress and maternal perinatal morbidity. METHODS: There were 1457 consecutive patients delivered of a singleton fetus in cephalic presentation beyond the 34th week of gestation at the I. Frauenklinik, Ludwig-Maximilians University, Munich between May 1999 and June 2000. The 257 patients (17.6%), who underwent cesarean section prior to or during labor, were excluded from the study. Of the 1200 vaginal deliveries, 1017 (84.8%) were normal spontaneous deliveries, while 183 (15.2%) were instrumentally assisted. Data were contemporaneously collected and analyzed for the presence of severe pelvic floor damage, maternal hemorrhage, maternal fever, delayed involution of the uterus, fetal acidosis and APGAR score, and the necessity for admitting the newborn to the intensive care unit (NICU). A second stage duration of > 2 hr was considered to be prolonged. RESULTS: The mean duration of the second stage of labor was 70 min (range 2-387, SD 73 min). For 952 patients (79.3%), the second stage was less than 2 h. For 47 patients (3.9%), it exceeded 4 h. A prolonged duration of the second stage was not associated with low Apgar scores 5 and 10 min postpartum (P = 0.76 and P = 0.38, respectively), a higher incidence of umbilical artery pH levels of < 7.20 (P = 0.60), nor with an increased rate of admission to the NICU (P = 0.24). A significant increase in the rate of maternal blood loss was noted after long second stages (1.84 g/dl median difference between the intrapartum and postpartum hemoglobin level) in comparison to patients with normal duration of second stage (0.79 g/dl), both by univariate (P < 0.0001) and multivariate (P < 0.001) analysis. The incidence of third degree anal sphincter tears was significantly correlated with a prolonged duration of second stage in univariate analysis (7.7%, P = 0.001), but not in multivariate analysis after allowing for duration of the second stage, maternal age, birth weight, episiotomy, and mode of delivery (P = 0.26). CONCLUSION: There is no evidence that prolonged second stage of labor is a serious disadvantage to the fetus, if adequate monitoring is provided. Because the increase of maternal morbidity in patients with prolonged labor may be partially attributed to a higher rate of operative procedures in these patients, interventions should not be solely based on the elapsed time after full cervical dilatation.


Subject(s)
Fetal Distress/etiology , Labor Stage, Second , Maternal Welfare , Obstetric Labor Complications , Pregnancy Outcome , Puerperal Disorders/etiology , Adolescent , Adult , Apgar Score , Birth Weight , Female , Humans , Infant, Newborn , Middle Aged , Pregnancy , Prognosis , Time Factors
16.
Am J Obstet Gynecol ; 186(3): 351-5, 2002 Mar.
Article in English | MEDLINE | ID: mdl-11904590

ABSTRACT

OBJECTIVE: This study was undertaken to test the null hypothesis that the number of striated muscle fibers in the ventral wall of the female urethra remains constant with increasing age. STUDY DESIGN: The urethra and surrounding tissues from 25 female cadavers, mean age 52 years (+/-SD 18, range 15-80 years), were selected for this study. Each specimen was divided along the midsagittal plane, and a Masson trichrome histologic section was prepared. A systematic count of striated muscle fibers in the ventral wall was then obtained at each decile of urethral length. RESULTS: A decrease in the total number of fibers within the sampled area was found with increasing age. The mean of the total fibers across all urethrae was 17,423 (+/-SD 9,624, range 4,788-35,867). Over the life span, an average of 364 fibers (2%) were lost per year (95% CI 197-531; P <.001). Mean fiber density was 671 (+/- SD 296, range 228-1374) fibers/mm2 and decreased by 13 fibers/mm2 per year (95% CI 8-17; P <.001). The mean lesser fiber diameter was 24 microm and did not change significantly with age ( P =.3). CONCLUSIONS: The number and density of urethral striated muscle fibers decline with age.


Subject(s)
Aging/physiology , Muscle, Skeletal/anatomy & histology , Urethra/anatomy & histology , Adolescent , Adult , Aged , Aged, 80 and over , Anatomy, Cross-Sectional , Female , Humans , Middle Aged , Muscle Fibers, Skeletal/ultrastructure
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