Subject(s)
Anilides/therapeutic use , Antineoplastic Agents/therapeutic use , Nitriles/therapeutic use , Salivary Ducts , Salivary Gland Neoplasms/drug therapy , Thiazoles/therapeutic use , Tosyl Compounds/therapeutic use , Class I Phosphatidylinositol 3-Kinases/genetics , Humans , Male , Middle Aged , Mutation , Neoplasm Staging , Receptors, Androgen/biosynthesis , Salivary Gland Neoplasms/genetics , Salivary Gland Neoplasms/metabolism , Salivary Gland Neoplasms/pathologyABSTRACT
BACKGROUND: Approximately 25-45% of schwannomas are typically slow-growing, encapsulated, and noninvasive tumors that occur in the head-and-neck region where they rarely involve the retropharyngeal space. Here, we report deep-seated benign plexiform schwannoma located in the retropharyngeal C2-C5 region excised utilizing the Smith-Robinson approach. CASE DESCRIPTION: A 30-year-old male presented with dysphagia and impaired phonation attributed to an MR documented C2-C5 retropharyngeal schwannomas. On examination, the lesion was soft, deep seated, and extended more toward the right side of the neck. Utilizing a right-sided Smith-Robinson's approach, it was successfully removed. The histopathology confirmed the diagnosis of a plexiform schwannoma. CONCLUSION: Retropharyngeal benign plexiform schwannomas are rare causes of dysphagia/impaired phonation in the cervical spine. MR studies best document the size and extent of these tumors which may be readily resected utilizing a Smith-Robinson approach.
ABSTRACT
Fondaparinux, a pentasaccharide administered for heparin-induced thrombocytopenia (HIT), can lead to the occurrence of thrombocytopenia. This patient underwent aortic stent graft placement for Salmonella paratyphi A-infected abdominal aortic aneurysm. Fondaparinux was administered for anticoagulation that led to a dramatic decline in his platelet counts. Investigations revealed HIT profile, PF4/heparin by particle gel immunoassay to be positive. Fondaparinux, a prescribed anticoagulant for HIT can paradoxically predispose to thrombocytopenia.