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Cesk Patol ; 39(3): 138-42, 2003 Jul.
Article in Czech | MEDLINE | ID: mdl-14631812

ABSTRACT

Comparative genomic hybridisation (CGH) allows to detect genetic abnormalities associated with poor prognosis in subset of patients with diffuse large B-cell lymphoma (DLBCL). Amplification of 2p13-16 represents an adverse genetic sign especially in extranodal DLBCL. In the present case, 2p13-16 amplification was revealed by CGH in extranodal DLBCL. It was localized in the mesentery and remained resistant to the chemotherapy (CHOP). A patient, 72-year-old female, died 10 weeks after the diagnosis had been made. Rapid lethal course of the disease confirms poor outlook for patients with 2p13-16 and supports a role of CGH as a sensitive method in prognosis for patients with DLBCL.


Subject(s)
Gene Amplification , Lymphoma, B-Cell/genetics , Lymphoma, Large B-Cell, Diffuse/genetics , Peritoneal Neoplasms/genetics , Aged , DNA, Neoplasm/genetics , Female , Humans , In Situ Hybridization, Fluorescence , In Situ Nick-End Labeling , Mesentery
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