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Klin Mikrobiol Infekc Lek ; 19(4): 132-7, 2013 Dec.
Article in Czech | MEDLINE | ID: mdl-24623054

ABSTRACT

We report a case of mycotic pneumonia in a patient with acute myeloblastic leukemia. Rhizopus microsporus was identified as an agent of mucormycosis and proven by microscopy and culture. The determination of the isolate was supported by molecular methods. Combined treatment with surgery (right-sided pneumonectomy) and systemic amphotericin B and posaconazole antifungal therapy was chosen. In this case, amphotericin B Neo-Sensitabs tablets gave false "resistant" results on Mueller-Hinton agar when using the disk diffusion test. There was a good correlation between the Etest (16 h) and the Sensititre YeastOne microplate (24 h) for amphotericin B.


Subject(s)
Lung Diseases, Fungal , Mucormycosis , Rhizopus , Amphotericin B/pharmacology , Amphotericin B/therapeutic use , Antifungal Agents/pharmacology , Antifungal Agents/therapeutic use , Humans , Leukemia, Myeloid, Acute/complications , Lung Diseases, Fungal/diagnosis , Lung Diseases, Fungal/drug therapy , Lung Diseases, Fungal/microbiology , Lung Diseases, Fungal/surgery , Mucormycosis/diagnosis , Mucormycosis/drug therapy , Mucormycosis/microbiology , Mucormycosis/surgery , Rhizopus/drug effects , Rhizopus/isolation & purification
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