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1.
J Nurs Meas ; 2023 Jun 22.
Article in English | MEDLINE | ID: mdl-37348894

ABSTRACT

Background and Process: Although the Brief COPE is a widely used instrument to measure coping, its factor structure is understudied in young adults. The purpose of this article was to determine the psychometric properties of the dispositional version of the Brief COPE among young adults. Methods: Two hundred young adults completed the dispositional version of the Brief COPE. Measures of depression, anxiety, and stress tested predictive validity. Confirmatory factor analyses and exploratory structural equation modeling were conducted. Results: The final model achieved good fit (minimum discrepancy/degrees of freedom [CMIN/df] = 1.59; comparative fit index [CFI] = .93; standardized root mean square residual [SRMR] = .07). Three second-order factors were identified: adaptive (α = .81), support (α = 78), and disengaged coping (α = 71). Adaptive and disengaged coping were differentially associated with mental health outcomes. Conclusions: The results are consistent with a growing body of evidence to support the construct validity of the Brief COPE.

2.
J Child Adolesc Trauma ; : 1-13, 2023 Feb 22.
Article in English | MEDLINE | ID: mdl-36844997

ABSTRACT

Adverse childhood experiences (ACEs) affect 22-75% of American young adults. ACEs are associated with adverse health outcomes that begin in young adulthood. Yet, scant research has examined if coping can mediate the relationship between ACEs and adverse outcomes. The current study determined if coping mediates the relationship between ACEs and body mass index (BMI), substance use, and mental health outcomes in young adults. A community sample of 100 White and 100 Black young adults 18-34 years of age participated in a cross-sectional study conducted via Zoom conferencing. Participants provided demographic data, height/weight, and completed measures of ACEs, coping, substance use, and mental health outcomes. Coping was measured using an established three-factor model consisting of adaptive, support, and disengaged coping. Structural equation modeling (SEM) examined the relationships of ACEs to outcomes as mediated by coping. Participants were predominantly female (n = 117; 58.5%) and mid-young adult (M = 25.5 years; SD = 4.1). SEM results indicated good model fit: (CMIN/df = 1.52, CFI = 0.94, RMSEA = 0.05 [90% CI = 0.03-0.07], SRMR = 0.06). Only disengaged coping mediated the ACE and substance use (ß = 0.36, p = .008), smoking (ß = 0.13, p = .004), and mental health (ß=-0.26, p = .008) relationships. Disengaged coping styles may be a critical mechanism in developing adverse mental health and substance use outcomes among ACE-exposed individuals. Future ACE and health outcomes research should examine the role of coping. Interventions focusing on adaptive coping may improve the health of individuals exposed to ACEs.

3.
J Am Psychiatr Nurses Assoc ; : 10783903221140325, 2022 Dec 01.
Article in English | MEDLINE | ID: mdl-36457165

ABSTRACT

BACKGROUND: Emerging evidence notes increased depression, anxiety, and stress among the general population during the COVID-19 pandemic. However, little is known about populations at increased risk for emotional distress as the pandemic continues. Persons with adverse childhood experiences (ACE) are one group that may be at higher risk for emotional distress. AIM: The aim of this study is to examine whether young adults, particularly Black young adults, with histories of ACEs report more emotional distress during the pandemic than those with no ACE exposure. METHOD: Using a cross-sectional, quota sampling approach, 100 Black and 100 White young adults were recruited using online sources (e.g., University website, Facebook). Due to the pandemic, participants were screened via Zoom and, if eligible, completed a demographic questionnaire, emotional distress measures (i.e., anxiety, depression, stress), and the ACE Questionnaire online via a Qualtrics survey. Structural equation modeling (SEM) analysis examined the ACE and emotional distress relationship, and multigroup SEM assessed racial differences. RESULTS: High levels of both emotional distress and ACEs were observed. Black young adults reported significantly more ACEs than Whites. ACEs were significantly associated with each measure of emotional distress regardless of race or other covariates. CONCLUSIONS: Findings reveal that during the pandemic, persons exposed to ACEs reported greater emotional distress than those with no ACE exposure. Nurses must screen patients for both emotional distress and ACE to target those at higher risk for early intervention and initiate treatment as needed to mitigate long-term mental health consequences.

4.
J Trauma Nurs ; 29(3): 142-151, 2022.
Article in English | MEDLINE | ID: mdl-35536343

ABSTRACT

BACKGROUND: Physiological trauma that requires admission to an emergency department may result in psychological distress. As many as 20%-40% of civilians who experience trauma develop traumatic stress disorders and depression postinjury. Yet, less than 10% of trauma centers implement screening for traumatic stress and depression risk. OBJECTIVE: This project aimed to develop, implement, and evaluate a traumatic stress and depression risk screening policy. METHODS: Twelve trauma advanced practice providers implemented the newly developed traumatic stress and depression risk screening policy at an American College of Surgeons verified Level II trauma center. Trauma patients admitted for greater than 24 hr, 14 years of age or older, with a Glasgow Coma Scale score greater than 13 were eligible for screening using the Injured Trauma Survivor Screen. RESULTS: During the 6-week data collection period, 114 trauma patients presented to the emergency department. Of those, 82 (72%) met inclusion criteria, 77 (94%) eligible trauma patients were screened, and seven (9%) patients screened positive. Patients not eligible for screening were discharged within 24 hr or were too confused to answer questions. An evaluation survey revealed that the advanced practice providers thought that the screening policy was easy to use, feasible, not very time-consuming, and should be continued in the future. CONCLUSION: This project demonstrated the ease and effectiveness of implementing a traumatic stress and depression risk screening policy and that only minor changes are needed to make it sustainable.


Subject(s)
Depression , Trauma Centers , Depression/diagnosis , Depression/epidemiology , Depression/etiology , Glasgow Coma Scale , Humans , Mass Screening , Survivors/psychology
5.
West J Nurs Res ; 44(6): 612-627, 2022 06.
Article in English | MEDLINE | ID: mdl-33942676

ABSTRACT

The Brief COPE is a widely used measure of coping that contains 28 items on 14 factors. Researchers have shortened the inventory, but the factor structure remains debated. A systematic review of peer-reviewed studies published in English between 1997 and 2021 was conducted to determine if a more parsimonious number of factors could be identified. Cumulative Index for Nursing and Allied Health, PsycINFO, PsycARTICLES, Medline, PubMed, and Scopus databases were searched using keywords "Brief COPE" and "factor, valid*, or psychometric.*" Searching yielded 1,303 articles; cited references added 38; 85 articles met inclusion criteria. Principal components analysis and confirmatory factor analysis were major analytic strategies used (28% and 27%, respectively). Only eight studies analyzed the original 14-factor structure. Factors identified ranged from 2 to 15, with dichotomous factors most frequently identified (25%; n = 21). A smaller number of factors may be able to represent the Brief COPE. Research is needed to test a condensed instrument.


Subject(s)
Adaptation, Psychological , Factor Analysis, Statistical , Humans , Psychometrics , Surveys and Questionnaires
6.
Nephrol Nurs J ; 48(6): 527-569, 2021.
Article in English | MEDLINE | ID: mdl-34935330

ABSTRACT

Change in fatigue within a hemodialysis (HD) session has not been established previously. A total of 55 cognitively intact adults on HD were included; individuals with mobility/hemodynamic issues were excluded. Measures included the Piper Fatigue Scale-12 (PFS-12), 6-Minute Walk Test (6MWT), demographic and clinical. Descriptive statistics, ANOVA, and stepwise regression were used. Mean age was 57 years. Mean change in PFS-12 was -4.56 ± 27.85. Mean change in walk distance was -16.26 ± 43.87 meters (p = 0.03). The change in the PFS-12 accounted for 47% quadratic trend in the change in 6MWD (p < 0.001). Both fatigue measures (PFS-12 and 6MWT) can be useful for examining changes in fatigue levels within an HD session. Our findings speak to the convergent validity of these two measures of fatigue.


Subject(s)
Fatigue , Walking , Adult , Fatigue/diagnosis , Fatigue/etiology , Humans , Middle Aged , Renal Dialysis/adverse effects , Walk Test
7.
Nurs Sci Q ; 34(4): 378-391, 2021 10.
Article in English | MEDLINE | ID: mdl-34538183

ABSTRACT

A middle-range theory of heart failure self-care, derived from the self-care deficit theory of nursing, was tested among 175 Arab American older adults with heart failure. The middle-range theory achieved good statistical fit, but not all hypothesized relationships were supported. Specifically, conceptualizing basic conditioning factors as a single latent variable was not supported. However, individual factors of depression, social support, and time living with heart failure had a direct effect on both self-care agency and quality of life. Understanding predictors and outcomes of self-care within a theoretical framework is essential in caring for patients with heart failure.


Subject(s)
Heart Failure , Self Care , Aged , Heart Failure/therapy , Humans , Quality of Life , Social Support
8.
Nurs Sci Q ; 34(2): 168-177, 2021 04.
Article in English | MEDLINE | ID: mdl-33749431

ABSTRACT

Middle-range nursing theories provide a bridge between the more abstract grand nursing theories, research, and clinical practice. As such, middle-range nursing theories derived from extant nursing theories are critical for developing and advancing both nursing science and practice. This paper describes the strategy used in developing a middle-range theory of heart failure self-care. After integrating theoretical and empirical literature, a hypothetico-deductive approach was used to develop the middle-range theory of heart failure self-care from Orem's theory of self-care. Theoretical substruction was used to provide a graphic representation of the conceptual-theoretical-empirical structure demonstrating the congruence between the theoretical and operational systems.


Subject(s)
Heart Failure , Self Care , Heart Failure/therapy , Humans , Nursing Theory
9.
J Reprod Immunol ; 145: 103305, 2021 06.
Article in English | MEDLINE | ID: mdl-33725526

ABSTRACT

Air pollution is associated with preterm birth (PTB), potentially via inflammation. We recently showed the mixture benzene, toluene, ethylbenzene, and xylene (BTEX) is associated with PTB. We examined if ambient BTEX exposure is associated with mid-pregnancy inflammation in a sample of 140 African-American women residing in Detroit, Michigan. The Geospatial Determinants of Health Outcomes Consortium study collected outdoor air pollution measurements in Detroit; these data were coupled with Michigan Air Sampling Network measurements to develop monthly BTEX concentration estimates at a spatial density of 300 m2. First trimester and mid-pregnancy BTEX exposure estimates were assigned to maternal address. Mid-pregnancy (mean 21.3 ± 3.7 weeks gestation) inflammatory biomarkers (high-sensitivity C-reactive protein, interleukin [IL]-6, IL-10, IL-1ß, and tumor necrosis factor-α) were measured with enzyme immunoassays. After covariate adjustment, for every 1-unit increase in first trimester BTEX, there was an expected mean increase in log-transformed IL-1ß of 0.05 ± 0.02 units (P = 0.014) and an expected mean increase in log-transformed tumor necrosis factor-α of 0.07 ± 0.02 units (P = 0.006). Similarly, for every 1-unit increase in mid-pregnancy BTEX, there was a mean increase in log IL-1ß of 0.06 ± 0.03 units (P = 0.027). There was no association of either first trimester or mid-pregnancy BTEX with high-sensitivity C-reactive protein, IL-10, or IL-6 (all P > 0.05). Ambient BTEX exposure is associated with inflammation in mid-pregnancy in African-American women. Future studies examining if inflammation mediates associations between BTEX exposure and PTB are needed.


Subject(s)
Air Pollutants/adverse effects , Black or African American/statistics & numerical data , Interleukin-1beta/blood , Premature Birth/immunology , Tumor Necrosis Factor-alpha/blood , Adolescent , Adult , Benzene/adverse effects , Benzene Derivatives/adverse effects , Biomarkers/blood , Environmental Exposure/adverse effects , Female , Humans , Interleukin-1beta/immunology , Maternal Exposure/statistics & numerical data , Pregnancy , Premature Birth/blood , Toluene/adverse effects , Tumor Necrosis Factor-alpha/immunology , Xylenes/adverse effects , Young Adult
10.
Nurs Res ; 69(5): 339-346, 2020.
Article in English | MEDLINE | ID: mdl-32865945

ABSTRACT

BACKGROUND: Increasing evidence views hypertension as a stress-induced disorder. Stressors must be "gated" by the brain before any inflammatory or immune processes that contribute to hypertension are initiated. No studies were found that examined sensory gating in relation to hypertension. OBJECTIVES: The aim of the study was to determine if disturbances in self-reported sensory gating could differentiate normotensive from hypertensive young adults. METHODS: A nonmatched, case-control design was used. We administered an online survey to 163 young adult participants. Participants were predominantly female, in their mid-20s, well educated, and approximately evenly distributed by race and hypertension status. The Sensory Gating Inventory (SGI) measured gating disturbances. RESULTS: The mean SGI scores were significantly higher among persons diagnosed with hypertension, reflecting a moderate effect size of sensory gating. After adjusting for confounders, however, the normotensive and hypertensive groups were not significantly different on their SGI scores. DISCUSSION: With an observed moderate effect size of 0.35, but low power, more research is warranted regarding the role of gating disturbances in the development of stress-induced hypertension. Clinically, the SGI may be important for screening patients who would benefit from ambulatory blood pressure monitoring to identify persons with masked hypertension.


Subject(s)
Hypertension/psychology , Sensory Gating/physiology , Stress, Psychological/complications , Adolescent , Adult , Blood Pressure Monitoring, Ambulatory/instrumentation , Blood Pressure Monitoring, Ambulatory/methods , Case-Control Studies , Female , Humans , Hypertension/etiology , Internet , Male , Michigan , Self Report , Stress, Psychological/psychology , Surveys and Questionnaires
11.
Nephrol Nurs J ; 47(3): 215-251, 2020.
Article in English | MEDLINE | ID: mdl-32639123

ABSTRACT

This study examined the severity, pattern, and correlates of fatigue among adults undergoing hemodialysis. Measures included the Piper Fatigue Scale (PFS-12), Patient-Reported Outcomes Measurement Information System (PROMIS) - Fatigue, Charlson Comorbidity Index, and Six-Minute Walk Test (6MWT). Patients were excluded if mobility or cardiovascular issues prevented conducting the 6MWT. Participants were 86 cognitively intact adults (M = 61.7 years, SD = 13.81), predominantly male (58.1%), and African American (48.8%), with 80% reporting fatigue in the week prior to hemodialysis. Significant increases were noted in sensory and cognitive fatigue from pre- to post-dialysis, while the 6MWT distance decreased significantly pre- to post-dialysis. Factors significantly associated with pre-dialysis fatigue included low hemoglobin, younger age, and living with someone else, while comorbidities and dialysis inadequacy were trending to significant associations with fatigue.


Subject(s)
Fatigue/epidemiology , Renal Dialysis , Aged , Female , Humans , Male , Middle Aged , Risk Factors
12.
West J Nurs Res ; 42(11): 927-936, 2020 11.
Article in English | MEDLINE | ID: mdl-32100645

ABSTRACT

This paper describes the assessment of the psychometric properties of the Brief COPE in a sample of 189 pregnant African-American women. Confirmatory factor analysis (CFA) tested the original 14-factor model, and exploratory structural equation modeling (ESEM) determined whether a reduced number of factors still accounted for inter-item covariances. The CFA replicated 13 of the 14 original factors. After deleting substance use items and allowing for correlated error across the support factors, the 13-factor model achieved an acceptable fit (CMIN/df = 1.77; RMSEA = 0.06, 95% CI = 0.05-0.07). ESEM resulted in three second-order factors: disengaged, active, and social support coping. Factor items were summed to create subscales with good internal consistency reliability (α = .74-.89). Social support coping and active coping were strongly correlated and accounted for nearly the same variance in four different psychological/affect scales, while disengaged coping was clearly distinct.


Subject(s)
Adaptation, Psychological , Black or African American/statistics & numerical data , Psychometrics , Social Support , Adult , Brief Psychiatric Rating Scale , Cross-Sectional Studies , Female , Humans , Pregnancy , Reproducibility of Results , Surveys and Questionnaires
13.
J Immigr Minor Health ; 22(1): 145-155, 2020 Feb.
Article in English | MEDLINE | ID: mdl-31811614

ABSTRACT

As the immigrant and refugee population continues to increase in the United States, healthcare providers need to be aware of Adverse Childhood Experiences (ACEs) these populations may have endured, and the potential health effects of these events. ACE research has been conducted with predominantly highly-educated, older Caucasians living in high-income countries which limits generalizability. A systematic review examined ACE prevalence and outcomes in persons living in poor, low-, and middle-income nations, often the home countries of U.S. immigrants and refugees. Fourteen studies conducted in 17 nations were included. Two main ACE measures were used. Prevalence of reporting at least one ACE ranged from 1.9% (Lebanon) to 80% (Saudi Arabia). Analysis established a graded dose-response, with increases in ACEs associated with increased risky behavior and negative health outcomes across all countries. Results reveal immigrants and refugees within the U.S. need to be evaluated for ACE exposure.


Subject(s)
Adverse Childhood Experiences/statistics & numerical data , Developing Countries/statistics & numerical data , Emigrants and Immigrants/statistics & numerical data , Refugees/statistics & numerical data , Cross-Sectional Studies , Female , Health Risk Behaviors , Health Status , Humans , Male , Mental Health/ethnology , Observational Studies as Topic , Risk-Taking , Socioeconomic Factors , Surveys and Questionnaires/standards
14.
ANS Adv Nurs Sci ; 41(4): E13-E25, 2018.
Article in English | MEDLINE | ID: mdl-30285981

ABSTRACT

This study tested the revised Beliefs About Personal Weight Survey-2 (BPWS-2) in 200 African American women, 18 to 40 years of age. Confirmatory factor analysis of a priori hypothesized factors resulted in 5 subscales-weight acceptance (8 items); excess weight acknowledgment (5 items); conventional weight regulation (3 items); circumstantial weight regulation (9 items); and weight concern (10 items). The Cronbach α ranged from 0.67 to 0.89. The factors demonstrated patterns of association with eating behavior, body mass index, body image, and psychosocial (depression and perceived stress) variables associated with weight. The BPWS-2 is the first instrument designed to measure beliefs about one's personal weight, thus results make important new contributions to the understanding of weight management.


Subject(s)
Attitude to Health/ethnology , Black or African American/psychology , Body Image/psychology , Body Mass Index , Body Weight/ethnology , Obesity/ethnology , Obesity/psychology , Adolescent , Adult , Black or African American/ethnology , Female , Humans , Psychometrics , Surveys and Questionnaires , United States , Young Adult
15.
Clin Nurs Res ; 26(2): 191-204, 2017 04.
Article in English | MEDLINE | ID: mdl-26396131

ABSTRACT

The rate of obesity within the United States is dropping, yet the prevalence of obesity among young African American women continues to increase. This increase, in part, may be attributable to weight beliefs. The relationship between beliefs about personal weight and body mass index (BMI) was examined among 150 African American women, 18 to 40 years of age using weight descriptive characteristics, causal attributions, consequences, and calculated BMI. Key results show that the majority of participants described their weight as attractive, healthy, and normal despite a sample mean BMI in the obese category. Key beliefs about the causes of personal weight that were associated and predictive of BMI were unhealthy eating behaviors, limited physical activity, weight left from pregnancy, and not knowing how to maintain a healthy weight. Beliefs about the consequences of personal weight were not predictive of BMI. A discussion of study findings provides important implications for clinical practice.


Subject(s)
Black or African American/psychology , Body Mass Index , Obesity/epidemiology , Adolescent , Adult , Exercise/physiology , Female , Humans , Life Style , Obesity/ethnology , Prevalence , United States
16.
ANS Adv Nurs Sci ; 40(2): E13-E27, 2017.
Article in English | MEDLINE | ID: mdl-27782910

ABSTRACT

The purpose of this study was to develop the Beliefs about Personal Weight Survey among African American women. Sixty-five items were developed from literature and sample participants to characterize beliefs about personal weight in 3 domains: descriptors, causes, and consequences. The items were administered to 150 community-dwelling African American women, 18 to 40 years old, recruited from 5 sites. Factor analysis supported a 4-factor solution with the following dimensions: overweight acceptance, overweight concern, conventional weight regulation, and circumstantial weight regulation. These factors were significantly associated with weight management behaviors and body mass index. Profile analysis indicated distinct factor belief profiles by 3 weight categories.


Subject(s)
Attitude to Health/ethnology , Black or African American/psychology , Black or African American/statistics & numerical data , Body Weight/ethnology , Obesity/ethnology , Obesity/psychology , Self Concept , Adolescent , Adult , Female , Humans , Program Development , Surveys and Questionnaires , United States , Young Adult
17.
West J Nurs Res ; 39(7): 886-905, 2017 07.
Article in English | MEDLINE | ID: mdl-27456461

ABSTRACT

This study examined the effects of an educative, self-regulation intervention on blood pressure self-efficacy, self-care outcomes, and blood pressure control in adults receiving hemodialysis. Simple randomization was done at the hemodialysis unit level. One hundred eighteen participants were randomized to usual care ( n = 59) or intervention group ( n = 59). The intervention group received blood pressure education sessions and 12 weeks of individual counseling on self-regulation of blood pressure, fluid, and salt intake. There was no significant increase in self-efficacy scores within ( F = .55, p = .46) or between groups at 12 weeks ( F = 2.76, p = .10). Although the intervention was not successful, results from the total sample ( N = 118) revealed that self-efficacy was significantly related to a number of self-care outcomes including decreased salt intake, lower interdialytic weight gain, increased adherence to blood pressure medications, and fewer missed hemodialysis appointments. Increased blood pressure self-efficacy was also associated with lower diastolic blood pressure.


Subject(s)
Blood Pressure/physiology , Patient Education as Topic/methods , Renal Dialysis/methods , Self Care , Self Efficacy , Female , Humans , Hypertension , Kidney Failure, Chronic , Male , Medication Adherence , Middle Aged , Renal Dialysis/psychology , Weight Gain
18.
J Pregnancy ; 2016: 4769121, 2016.
Article in English | MEDLINE | ID: mdl-27418977

ABSTRACT

Introduction. Menarche is a critical time point in a woman's reproductive system development; exposures at menarche may influence maternal health. Living in a poorer neighborhood is associated with adult obesity; however, little is known if neighborhood factors at menarche are associated with prepregnancy obesity. Methods. We examined the association of neighborhood-level poverty at menarche with prepregnancy body mass index category in 144 pregnant African-American women. Address at menarche was geocoded to census tract (closest to year of menarche); neighborhood-level poverty was defined as the proportion of residents living under the federal poverty level. Cumulative logistic regression was used to examine the association of neighborhood-level poverty at menarche, in quartiles, with categorical prepregnancy BMI. Results. Before pregnancy, 59 (41%) women were obese. Compared to women in the lowest neighborhood-level poverty quartile, women in the highest quartile had 2.9 [1.2, 6.9] times higher odds of prepregnancy obesity; this was slightly attenuated after adjusting for age, marital status, education, and parity (odds ratio: 2.3 [0.9, 6.3]). Conclusions. Living in a higher poverty neighborhood at menarche is associated with prepregnancy obesity in African-American women. Future studies are needed to better understand the role of exposures in menarche on health in pregnancy.


Subject(s)
Black or African American/statistics & numerical data , Menarche , Obesity/epidemiology , Poverty/statistics & numerical data , Pregnancy Complications/epidemiology , Residence Characteristics , Adult , Body Mass Index , Female , Humans , Logistic Models , Odds Ratio , Pregnancy , Young Adult
19.
J Reprod Immunol ; 115: 1-5, 2016 06.
Article in English | MEDLINE | ID: mdl-27061480

ABSTRACT

Although inflammation is associated with risk of gestational diabetes mellitus (GDM), little is known if there is an association between inflammation and GDM in African-American women, a group at higher risk for GDM complications. In the present study, we aimed to determine if selected inflammatory cytokines (i.e. TNF-α, hs-CRP, IL-6, IL-10, IL-6/IL-10 ratio, IL-1ß) measured in the 2nd trimester, were associated with GDM risk in 185 pregnant African-American women. GDM was defined as a physician-documented GDM diagnosis, a fasting glucose between 92 and 125mg/dl, or evidence of glucose intolerance (defined using the 3-h glucose tolerance test). A total of 18 women (9.7%) had GDM. After covariate adjustment, C-reactive protein, measured at a mean 21.2±3.7 weeks gestation, was statistically significantly associated with GDM development (P=0.025); for every one-unit increase in log-transformed C-reactive protein, the odds of GDM increased by 5.3. Results were similar using a principal component analysis approach. This study provides evidence that higher levels of 2nd trimester C-reactive protein is associated with increased risk of GDM in African-American women. Further research is needed to examine whether C-reactive protein may be a useful early-pregnancy screen for evaluating potential GDM risk in African-American women.


Subject(s)
Black or African American , C-Reactive Protein/metabolism , Diabetes Mellitus/epidemiology , Inflammation/epidemiology , Pregnancy Complications/epidemiology , Adolescent , Adult , Biomarkers/metabolism , Cytokines/blood , Diabetes Mellitus/immunology , Female , Humans , Inflammation/immunology , Inflammation Mediators/metabolism , Pregnancy , Pregnancy Complications/immunology , Principal Component Analysis , Risk , United States/epidemiology , Young Adult
20.
Arch Womens Ment Health ; 19(2): 373-83, 2016 Apr.
Article in English | MEDLINE | ID: mdl-26407996

ABSTRACT

Vitamin D deficiency and elevated pro-inflammatory cytokines have each been associated individually with postpartum depression (PPD). African American women are at increased risk for prenatal vitamin D deficiency, inflammation, and prenatal and postpartum depressive symptoms, but biological risk factors for PPD in this population have rarely been tested. This prospective study tested whether low prenatal vitamin D status (serum 25-hydroxyvitamin D, 25[OH]D) predicted PPD symptomatology in pregnant African American women and whether high levels of prenatal inflammatory cytokines interacted with low 25(OH)D in effects on PPD symptoms. Vitamin D status was measured in the first trimester in a sample of 91 African American pregnant women who had a second trimester blood sample assayed for inflammatory markers. Depressive symptoms were assessed at a postpartum visit. An inverse association between prenatal log 25(OH)D and PPD symptomatology approached significance (ß = -0.209, p = 0.058), and interleukin-6 and IL-6/IL-10 ratio significantly moderated the effect. Among women with higher levels of inflammatory markers, lower prenatal log 25(OH)D was associated with significantly higher PPD symptoms (p < 0.05). These preliminary results are intriguing because, if replicable, easy translational opportunities, such as increasing vitamin D status in pregnant women with elevated pro-inflammatory cytokines, may reduce PPD symptoms.


Subject(s)
Black or African American/psychology , Cytokines/blood , Depression, Postpartum/ethnology , Depression/ethnology , Pregnancy Complications/psychology , Vitamin D Deficiency/psychology , Vitamin D/analogs & derivatives , Adolescent , Adult , Black or African American/statistics & numerical data , Depression/blood , Depression/psychology , Depression, Postpartum/blood , Depression, Postpartum/psychology , Female , Humans , Interleukin-6/blood , Pregnancy , Pregnancy Complications/blood , Pregnancy Complications/ethnology , Prospective Studies , Psychiatric Status Rating Scales , Regression Analysis , Socioeconomic Factors , Vitamin D/blood , Vitamin D Deficiency/blood , Vitamin D Deficiency/ethnology , Young Adult
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