Immunohistochemical diagnosis of chronic wasting disease in preclinically affected elk from a captive herd.

An immunohistochemical (IHC) method was used to test brain tissues from 17 elk in a captive herd in which chronic wasting disease (CWD) had previously occurred. The IHC technique detects the protease-resistant prion protein (PrP-res), which is considered a disease-specific marker for transmissible spongiform encephalopathies (TSE), regardless of the species affected. Of the 17 elk tested, 10 were positive by IHC. Only 2 of these 10 animals had shown clinical signs and histologic lesions of CWD, and an additional animal had histologic lesions only. The most consistently IHC-positive tissue was medulla oblongata, especially the obex. These results show that the PrP-res IHC test on brain tissue, specifically medulla oblongata at the obex, should be considered an essential component of any surveillance study intended to determine the incidence of CWD in captive or free-ranging cervids.

Assessment and evaluation of football performance.

The most important variables for measuring performance in team sports such as football are physical condition and technical and tactical performance. However, because of the complexity of the game of football it is difficult to ascertain the relative importance of each of these variables. The aim of the present study was to develop a standardized test battery to evaluate physical performance in football players. The F-MARC test battery was designed to closely relate to the football player's normal activity and comprised a functional, structured training session of approximately 2.5 hours. It included a "quality rating" of the warm-up procedure, tests of flexibility, football skills, power, speed, and endurance. The players finished with a cool-down. A total of 588 football players underwent the F-MARC test battery. Mean values for performance on each test are presented for groups of differing age and skill levels. The test battery proved to be a feasible instrument to assess both physical performance and football skills. This study supports the proposal by Balsom (1994) that analysis of an individual player's physical profile, in relation to mean values for a similar age group and skill level, might be of assistance to the coach in objectively evaluating the effects of a specific training program. It may also be of use to the physician and physical therapist responsible for monitoring progress during rehabilitation after football injuries.

An assessment program to reduce drug use with the mentally retarded.

Growing concern over possible institutional drug abuse has made it extremely important to identify procedures to systematically evaluate the therapeutic effectiveness of drugs. The authors describe a two-phase drug assessment program that has permitted an intermediate care facility for the mentally retarded to reduce its reliance on psychoactive medication and to meet the mandates of accreditation and law. The first phase identified individuals who could effectively participate in treatment without medication. The second phase identified minimum effective dosages for those whose maladaptive behavior could not be controlled when medication was abruptly removed. Therapeutic benefits resulting from this individualized drug reduction program are discussed, as are the economic and programmatic benefits to the institution.