[Appropriateness of the prescriptions of conventional versus new oral anticoagulants at discharge from a department of internal medicine]. / Pertinence des prescriptions d'anticoagulants oraux à la sortie d'un service de médecine interne d'un hôpital régional suisse.

BACKGROUND: The recently introduced oral direct anticoagulants (ODAs), presumably safer, and with comparable efficacy to the vitamin K antagonists (VKAs), may reshape the world of anticoagulation medicine. This study aimed to assess the prescription appropriateness of ODAs and VKAs at discharge from hospital. METHODS: We performed a one year retrospective study between August 2012 and July 2013 in the department of internal medicine of a regional hospital (HVs Sion) using Electronic Medical Records. All patients receiving an ODA were included and matched to a patient treated with a VKA. The appropriateness of prescription at discharge was defined by an adequate indication and dosing, the absence of contraindication, a minimal risk of drug-drug interactions and no major bleeding or venous thromboembolism during the hospitalization. The bleeding risk was evaluated with the HAS-BLED score when the indication was atrial fibrillation (AF). RESULTS: Out of the 44patients included (22 with an ODA and 22 with a VKA), 38 received an appropriate prescription according to all criteria. Two patients had an inadequate dosing. A potential drug-drug interaction was detected in 3patients receiving a VKA and in 1patient receiving an ODA. No major contraindication was found, but a relative contraindication was discussed in 3cases. The majority of patients receiving an ODA for an AF had a minor bleeding risk. CONCLUSION: No significant difference was ascertained between the two groups regarding the appropriateness of prescription. Our results suggest that ODAs were cautiously used in our setting.

[Septic arthritis]. / Arthrite septique.

Septic or acute bacterial arthritis is a medical emergency. The primary physician must suspect this condition even when clinical symptoms are non specific or with simultaneous inflammatory arthropathy. Septic arthritis can have serious complications. Optimal care requires hospital admission in general. Synovial fluid aspiration and its correct interpretation, the appropriate choice and timely administration of empiric antibiotic therapy can limit destruction of the joint's cartilage. The adaptation of the antibiotic regimen after reception of microbiological results and the adequate treatment in full length require interdisciplinary collaboration between the hospital physician, including the specialist in infectious diseases, the microbiology laboratory and post-hospital care.

[Diagnostic of Pneumocystis jirovecii pneumonia in a non HIV patient]. / Diagnostic de la pneumonie à Pneumocystis jirovecii chez le patient non VIH.

Pneumocystis jirovecii pneumonia is an opportunistic infection affecting not only HIV patient but also patients with others causes of immunosuppression. The reference method for the diagnostic is the direct visualization of the pathogen in induced sputum or in bronchoalveolar lavage with a low sensibility. Direct immunofluorescence does not increase significantly this sensibility on IS. The PCR has been demonstrated to have 100% sensitivity. This gives rise to the problem of falsely positive results in patients, colonized by P. jiroveci (8,9-26,9%) but suffering from a pneumonia due to another pathogen. Use of quantitative PCR or serum beta-D-glucan, might be helpful to distinguish colonization from infection. This paper reviews the literature on the diagnostic of PCP in non HIV patients.

[Proper usage of procalcitonin]. / Du bon usage de la procalcitonine.

In the last fifteen years, procalcitonin measurement has been evaluated as a rapid diagnostic aid for suspected infection. Procalcitonin is now widely used in any febrile patient despite the lack of evidence supporting that practice. Indeed, procalcitonine has proven effective in the intensive care setting, as a diagnostic aid for septic shock, as a prognostic instrument and to tailor the duration of antibiotic treatment. Studies in non intensive care settings are more recent and scarce. Procalcitonin has been assessed in the emergency department in patients with lower respiratory tract infections and in patients admitted for an acute febrile illness. Results are encouraging but preliminary, therefore procalcitonine measurement should be restricted to patients with criteria of severe infection for the time being.

[The management of the alcohol withdrawal syndrome in the intensive care unit]. / Syndrome de sevrage alcoolique en milieu de soins intensifs.

The management of the alcoholic withdrawal syndrome in the intensive care unit is difficult. Clearly, the patient must be sedated, in order to avoid the side-effects of agitation, like trauma. However, a too much enthusiastic sedation has to be avoided, first because it may unmask neurologic important information, and, second, because it can prolong or complicate the ICU stay. In this review, we discuss the actual management of the alcoholic withdrawal syndrome in the ICU.