ABSTRACT
La urgente necesidad social y ética de dar tratamiento médico satisfactorio a numerosos pacientes con leishmaniasis cutánea localizada, urbana, en el estado Trujillo de Venezuela, sin complicaciones mucosas entre mas de 2000 casos estudiados desde 1984, nos ha conducido a la síntesis y utilización perilesional de un complejo antimonial pentavalente con glucamina (ULAMINA). Se resume el procedimiento para la preparación de ULAMINA y se compara su composición en especies de antimonio, concentración de cloruros, densidad, pH y osmolaridad con muestra de tres patentados comerciales importados, con resultados análogos. Se reportan resultados clínicos satisfactorios en el tratamiento perilesional de 858 pacientes con ULAMINA, con un 5% de casos que abandonaron el tratamiento sin la cicatrización de sus lesiones.
Subject(s)
Humans , Leishmaniasis, Cutaneous/therapy , Meglumine/therapeutic use , Treatment Outcome , Environmental Health , Medicine , VenezuelaABSTRACT
A continuous flow system for the determination of lead in home made spirituous beverages was developed. The determination was based on the formation of a neutral chelate of the element with ammonium pyrrolidine dithiocarbamate, its adsorption onto a minicolumn packed with sodium faujasite type Y synthetic zeolite, followed by elution with methyl isobutyl ketone and determination by flame atomic absorption spectrometry. Ethanol and copper interfere strongly in the determination and therefore, must be separated prior to the analysis. Copper is removed by precipitation with rubeanic acid, while ethanol is eliminated by rotaevaporation. Sample solutions containing Pb(2+) in the concentration range from 5 to 120mugl(-1) at pH 2.5 could be analyzed, by using a preconcentration time of 3min. Preconcentration factors from 80 to 140 were achieved for a sample volume of 6ml and the detection limit varied from 1.4 to 3.5mugl(-1), depending on the matrix composition. The relative standard deviations for 60mugl(-1) Pb was 3.2% (n = 10) and the recovery of spikes (20, 40, 60 and 80mugl(-1)) added to the samples was estimated within 92-105% range, suggesting that lead can be quantitatively determined in such samples. Determining lead in several samples by an alternative technique further checked the accuracy. Finally, the concentrations of Pb(2+) determined in 28 samples of Venezuelan spirituous beverages were in 12.6-370.0mugl(-1) range, depending on the fermenting material based on different mixtures of agave, raw sugar cane and white sugar.
