[Experimental study of the effectiveness of interleukin-1beta in radiation injury]. / Eksperimental'noe issledovanie éffektivnosti interleikina-1beta pri luchevom porazhenii.

The experiments on mice exposed to radiation (6.5 Gy, LD 80/30) discovered that human recombinant interleukin-1 beta after administration on postradiation hour 1-3 increased the animals' survival by 40-70%. Interleukin-1 beta reduced leukopenia and enhanced the recovery of bone marrow cell elements. The use of the preparation as an early pathogenetic treatment of irradiation damage holds promise.

[Experimental study of therapeutic efficacy of plasmapheresis in acute radiation injury]. / Eksperimental'noe issledovanie terapevticheskoi éffektivnosti plazmafereza pri ostrom radiatsionnom porazhenii.

In experiments with dogs exposed to 2.9 Gy (LD80/45) it was found that plasmapheresis treatment 4-6 h after irradiation reduce the severity of the radiation sickness clinical manifestations and post-radiation toxemia thus increasing the rate of animal survival up to 60%. Sham plasmapheresis included all the manipulations of plasmapheretic treatment except plasma substitution and had no detoxication effect and did not affect the irradiated animals survival. This is evidence for leading role of detoxication in the mechanisms of the therapeutic action of plasmapheresis in acute irradiation.

[Clinical and experimental investigation on the radioprotective effect of riboxine in low-dose fractionated irradiation]. / Kliniko-éksperimentalnoe issledovanie radiozashchitnoi éffectivnosti riboksina pri fraktsionirovannom obluchenii v malykh dozakh.

In experiments with dogs (fractionated y-irradiation, accumulated dose 1Gy) as well as in clinical testing of the group of men, recieved 0,25 Gy being engaged in the Chernobyl NPS disaster repairment, the positive influence of riboxin (purine nucleoside) course treatment on parameters of peripheral blood and non-specific resistance system has bee n shown.

[Effect of riboxine on mice resistance to long-term gamma-irradiation in non-lethal dose]. / Vliianie riboksina na rezistentnost myshei k prolongirovannomu gamma-oblucheniiu v neletalnoi doze.

In experiments with mice subjected to long-term irradiation with a non-lethal dose of 4 Gy, (0.017 Gy/min), it has been shown that the number of chromosome aberrations in myelocaryocytes is reduced, the cell precursors pool in the bone marrow and the germinative epithelium are unchanged, the number of lipid radiotoxins decreases, and cell membranes are stabilized after a single dose of a purine nucleoside, riboxine (150 mg/kg, 12 h prior to irradiation).