ABSTRACT
Secondary amyloidosis was diagnosed in five Rhesus monkeys with chronic indwelling venous catheters. Diagnostic enzymology demonstrated normal serum alanine aminotransferase concentration and consistently elevated serum alkaline phosphatase. Serum protein electrophoresis on all five animals showed a typical pattern of decreased albumin and increased gamma globulin. Necropsy or biopsy specimens verified the presence of amyloid deposits in all animals. The diagnostic usefulness of clinical enzymology, serum protein electrophoresis and liver biopsy were demonstrated and the importance of considering amyloidosis as a differential diagnosis in monkeys with indwelling vascular catheters is emphasized.
Subject(s)
Amyloidosis/veterinary , Catheters, Indwelling/veterinary , Macaca mulatta , Macaca , Monkey Diseases/etiology , Alanine Transaminase/blood , Alkaline Phosphatase/blood , Amyloidosis/diagnosis , Amyloidosis/etiology , Animals , Animals, Laboratory , Biopsy/veterinary , Blood Proteins/analysis , Catheters, Indwelling/adverse effects , Female , Hepatomegaly/veterinary , Male , Monkey Diseases/diagnosis , Spleen/pathologyABSTRACT
In vitro granulocyte-killing assays were performed to examine the ability of granulocytes from pasteurella-free or immunized rabbits, the in combination with specific immune serum, to kill Pasteurella multocida. Granulocytes from healthy rabbits and from rabbits with P multocida infections were equally competent. Granulocyte source, serum source, and specific antibody titer had no effect on granulocyte phagocytic activity. Moreover, serum containing specific antibody and complement supported the growth of the bacterium. These data suggest that chronic P multocida infections are not attributable to defective granulocytes or lack of serum antibody production.
