ABSTRACT
The authors assessed the levels of lactate and 2,3 diphosphoglycerate in the umbilical blood of 105 full-term neonates. A significant increase was found in the levels of 2,3 diphosphoglycerate in newborns of mothers with a history of imminent chronic intrauterine hypoxia. The lactate levels of these newborns were the same as in children of mothers without a history showing a risk of intrauterine hypoxia. The psychomotor development of newborns with increased levels of 2,3 diphosphoglycerate was significantly more altered than in those with normal levels in their first year of life.
Subject(s)
Diphosphoglyceric Acids/blood , Fetal Blood/analysis , Fetal Hypoxia/diagnosis , 2,3-Diphosphoglycerate , Chronic Disease , Erythrocytes/metabolism , Female , Humans , Infant, Newborn , Lactates/blood , Lactic Acid , Pregnancy , Pregnancy ComplicationsSubject(s)
Brain/growth & development , Infant Nutritional Physiological Phenomena , Infant, Newborn, Diseases/physiopathology , Child, Preschool , Epilepsy/etiology , Female , Follow-Up Studies , Humans , Infant , Infant, Newborn , Infant, Newborn, Diseases/diet therapy , Pregnancy , Psychomotor Performance , Pyrithioxin/administration & dosageABSTRACT
The authors examined 91 neonates with one or several anamnestic signs of intra-partum hypoxia (cardiotocographic record, pH in blood of umbilical artery, Apgar score) and 65 neonates with a normal delivery. When evaluating signs of hypoxia, a very low correlation between the methods used was found. Neurological investigation of all children revealed significant differences in the incidence of neurological abnormalities between groups of hypoxic neonates (whatever method used) and the group of neonates without a history of hypoxia intra partum, but only in the second month. In the other age periods, when the children were subjected to neurological examination (6, 12 months), no differences were found in the frequency of neurological abnormalities between the group of "hypoxic" and normal children.
