ABSTRACT
In a patient with Wolff-Parkinson-White syndrome and an inferior-posterior bypass tract, transient restoration of normal conduction occurred during an attack of angina. The ECG pattern of inferior posterior ischemia was present when the conduction was normal. Thallium scintigraphy showed a reversible posterolateral perfusion defect. The possible mechanisms for production of intermittent preexcitation are discussed.
Subject(s)
Angina Pectoris/diagnosis , Electrocardiography , Heart Conduction System/physiopathology , Wolff-Parkinson-White Syndrome/diagnosis , Aged , Angina Pectoris/physiopathology , Heart/diagnostic imaging , Humans , Male , Radionuclide Imaging , Thallium Radioisotopes , Wolff-Parkinson-White Syndrome/physiopathologySubject(s)
Erythrocyte Aggregation , Hypertension/blood , Adult , Humans , Hypertension/classification , MaleSubject(s)
Beta-Globulins/biosynthesis , Blood Coagulation Disorders/complications , Hypertension/blood , beta-Thromboglobulin/biosynthesis , Blood Coagulation Disorders/blood , Female , Humans , Hypertension/complications , Male , Platelet Aggregation , Pre-Eclampsia/blood , Pregnancy , Pregnancy Complications, Cardiovascular/bloodABSTRACT
The possibility of occurrence of daily variations in blood fibrinogen levels, platelets aggregation. Howell's time values and values for PTT, TT and antithrombin III was explored in 10 healthy subjects and in 10 patients with vascular disease. In normal subjects blood fibrinogen, platelets aggregation in ADP, PTT, Howell's time and TT values showed statistically significant daily variations, while the AT III values showed no significant variations over the 24-h cycle. In patients with vascular disease, on the other hand, the daily variations of the fibrinogen blood levels, of the maximum amplitude of platelets aggregation and of the Howell's values were not detected. In fact, the first two parameters remained consistently high and the third parameter remained consistently low throughout the 24-h cycle. In contrast, the PTT as well as the TT values in these patients showed statistically significant daily variations but with time patterns different than those found in normal subjects. Also, unlike to what obtained in healthy subjects, the AT III values in patients with vascular disease showed highly significant variations over the period of 24-h.
Subject(s)
Antithrombin III/analysis , Blood Coagulation Tests , Circadian Rhythm , Fibrinogen/analysis , Platelet Aggregation , Vascular Diseases/physiopathology , Arteriosclerosis/physiopathology , Humans , Male , Myocardial Infarction/physiopathology , Partial Thromboplastin Time , Reference Values , Thrombin TimeSubject(s)
Coronary Disease/blood , Fibrinogen/analysis , Hypertension/blood , Prothrombin Time , Humans , MaleABSTRACT
The action of ketoprofen on the calciuric and uricosuric effects of porcine calcitonin in man is reported. The drug is capable of inhibiting both effects. This action is considered like an effect on CT receptors in the kidney or a competitive action on prostaglandin synthesis.
Subject(s)
Calcitonin , Calcium/urine , Ketoprofen , Phenylpropionates , Uric Acid/urine , Adult , Calcium/blood , Humans , Male , Middle Aged , Uric Acid/bloodSubject(s)
Glycated Hemoglobin/analysis , Myocardial Infarction/blood , Adult , Aged , Female , Humans , Male , Middle Aged , Myocardial Infarction/diagnosisSubject(s)
Calcitonin , Growth Hormone/blood , Insulin , Adult , Animals , Blood Glucose/metabolism , Calcium/metabolism , Humans , Hypoglycemia/chemically induced , Male , Salmon , Time FactorsABSTRACT
A study of the effects of salmon calcitonin (sCT) infusion on blood sugar and serum insulin levels under basal conditions and after intravenous glucose load in normal subjects is reported. Under basal conditions, a 30 min infusion of sCT at approximately a rate of 1 U/min produced a highly significant increase in the blood sugar (p less than 0.01) and a highly significant decrease in the serum insulin levels (p less than 0.01). After intravenous glucose load, there was a decrease of the coefficient of glucose utilization and of the insulin response both of which were highly significant (p less than 0.01).
Subject(s)
Blood Glucose/metabolism , Calcitonin , Glucose Tolerance Test , Insulin/blood , Adult , Animals , Glucose , Humans , Kinetics , Male , Middle Aged , SalmonSubject(s)
Carbohydrate Metabolism , Diabetes Mellitus/drug therapy , Glucose Tolerance Test , Nifedipine/therapeutic use , Pyridines/therapeutic use , Adult , Aged , Blood Glucose/analysis , Calcium/metabolism , Diabetes Mellitus/metabolism , Humans , Insulin/blood , Male , Middle Aged , Nifedipine/pharmacologyABSTRACT
The Authors have studied th haemodynamic response of ten normal subjects to the intravenous administration of 160 MRC.U. of Calcitonin in 60 min, by serial measurement of the systolic time intervals. The analysis of results pointed out a minor inotropic effect starting from the 10th minute from the beginning of the infusion. Little but significant decrements (P less than 0.01) in the duration of the pre-ejection phase of the isovolumetric contraction time, as well as a significant increase (P less than 0.01) in the LVET/PEP ratio, have been noted. A negative chronotropic effect (P less than 0.05) has been noted starting from the 30th minute. The mechanism by which Calcitonin can modify the myocardial inotropism in the normal subject is till now unknown, and it could be related to the interference of this hormore on the endocellular movements of Calcium, and on the cellular levels of cyclic AMP.
Subject(s)
Calcitonin/pharmacology , Myocardial Contraction/drug effects , Adult , Blood Pressure/drug effects , Calcium/blood , Electrocardiography , Heart Rate/drug effects , Humans , Male , Middle Aged , Systole/drug effectsABSTRACT
The therapeutical activity of a new oral drug with a coronaric and myocardiotrophic action of choice, 2-benzofuryl-p-chlorophenyl-carbinol (Menacor, Menarini) in 20 patients with chronic coronary insufficiency was studied by administering 750 mg/day for at least 20 days. General and gastroenteric tolerance was excellent, while good or fair therapeutic results were obtained in 16 cases (80%). It is felt that the drug can be usefully employed in the management of coronary insufficiency.
