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1.
Rev Med Chir Soc Med Nat Iasi ; 116(2): 452-6, 2012.
Article in Romanian | MEDLINE | ID: mdl-23077936

ABSTRACT

UNLABELLED: The study aim was to assess some features of samples of patients assisted for viral hepatitis B and C, as well as cirrhosis, and included in a national antiviral treatment protocol. MATERIAL AND METHODS: The study considered patients assisted in the medical assurance system in the Bacau County, Romania, during 2007 and 2010. RESULTS: A sample of 1127 patients with chronic viral hepatitides B and C was assisted, from which 154 cases with B virus (13.7%) with a male predominance and 973 with C virus (86.3%) and a female predominance. An increase trend for both hepatitides prevalence was highlighted and a number of non-responders every year (18.1% of total cases). CONCLUSIONS: A correct diagnosis and treatment of\cases with chronic viral hepatitis B and C and to have a smaller number ofnon-responders represent major purposes of specialists in the Bacau County also.


Subject(s)
Hepatitis B, Chronic/diagnosis , Hepatitis C, Chronic/diagnosis , Liver Cirrhosis/diagnosis , Liver Cirrhosis/virology , Antiviral Agents/therapeutic use , Female , Hepatitis B, Chronic/drug therapy , Hepatitis B, Chronic/epidemiology , Hepatitis C, Chronic/drug therapy , Hepatitis C, Chronic/epidemiology , Humans , Interferon-alpha/therapeutic use , Liver Cirrhosis/drug therapy , Liver Cirrhosis/epidemiology , Male , Middle Aged , Prevalence , Risk Factors , Romania/epidemiology , Sampling Studies , Sex Distribution
2.
Rev Med Chir Soc Med Nat Iasi ; 116(3): 750-5, 2012.
Article in English | MEDLINE | ID: mdl-23272522

ABSTRACT

AIM: Biochemical and ultrasound investigations in patients with chronic hepatitis C on a 48-week anti-viral regimen. MATERIAL AND METHODS: A group of 6 patients, 4 women and 2 men, age range 24-61, were evaluated at the beginning of therapy and compared after 48 weeks of peginterferon alfa-2a and peginterferon alpha-2b regimen at doses established by the National Treatment Program approved by the Romanian National Health Insurance House. RESULTS: ALT and AST levels have decreased in all patients. The viral load was undetectable in two patients, both females, after 48 weeks of therapy. Ultrasound images showed a decrease in size of the right and left hepatic lobes and portal vein diameter after 48 weeks. CONCLUSIONS: Inhibition of virus by interferon and ribavirin resulted in the reduction of inflammatory phenomena and regenerative fibrosis noticed after a very long period of time (at least 48 weeks). Further studies performed on larger patient groups are needed in order to better describe all these changes.


Subject(s)
Antiviral Agents/therapeutic use , Hepatitis C, Chronic/blood , Hepatitis C, Chronic/diagnostic imaging , Interferon-alpha/therapeutic use , Polyethylene Glycols/therapeutic use , Ribavirin/therapeutic use , Adult , Alanine Transaminase/blood , Antiviral Agents/administration & dosage , Aspartate Aminotransferases/blood , Biomarkers/blood , Female , Hepatitis C, Chronic/drug therapy , Humans , Interferon alpha-2 , Interferon-alpha/administration & dosage , Male , Middle Aged , Polyethylene Glycols/administration & dosage , Recombinant Proteins/administration & dosage , Recombinant Proteins/therapeutic use , Ribavirin/administration & dosage , Time Factors , Treatment Outcome , Ultrasonography , Viral Load/drug effects
3.
Rev Med Chir Soc Med Nat Iasi ; 113(1): 84-8, 2009.
Article in Romanian | MEDLINE | ID: mdl-21495302

ABSTRACT

The paper presents the results of a 83-cases study that have been admitted into the local hospital, with from gall stones, between September 1st, 2006 and April 1st, 2007. The study purpose was the research of gall suffering affections and/or together with other pathologies, in order to highlight age and gender peculiarities, as well as to show other pathologies that seems to have a connection with gall suffering. Paraclinical investigations were necessary for the diagnosis, and complication monitoring.


Subject(s)
Ambulatory Care Facilities , Cholecystectomy , Gallstones/diagnosis , Gallstones/surgery , Gastroenterology , Adult , Age Distribution , Aged , Body Mass Index , Dyslipidemias/complications , Early Diagnosis , Female , Gallstones/epidemiology , Gallstones/etiology , Gallstones/prevention & control , Humans , Male , Middle Aged , Obesity/complications , Outpatients/statistics & numerical data , Prevalence , Retrospective Studies , Risk Factors , Romania/epidemiology , Sex Distribution , Treatment Outcome
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