1.
Cardiovasc Res
; 51(1): 9-12, 2001 Jul.
Article
in English
| MEDLINE
| ID: mdl-11399242
Subject(s)
Calcium/metabolism , Isoenzymes/metabolism , Myocardial Contraction/physiology , Myocardium/enzymology , Sodium-Potassium-Exchanging ATPase/metabolism , Animals , Cardiac Glycosides/metabolism , Dose-Response Relationship, Drug , Enzyme Inhibitors/pharmacology , Guinea Pigs , Isoenzymes/antagonists & inhibitors , Mice , Models, Animal , Ouabain/pharmacology , Perfusion , Rats , Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors
2.
Circ Res
; 88(1): 9-11, 2001 Jan 19.
Article
in English
| MEDLINE
| ID: mdl-11139467
ABSTRACT
The effects of alterations in calcium in the perfusion media were studied on ss-adrenergic coupling in isolated hearts from 3 different transgenic mice: cardiac-specific overexpressed alpha(1) subunit of L-type calcium channel, overexpressed Galpha(q), and phospholamban knockout. Isolated hearts from all 3 models, when studied at [Ca(2+)] of 2 mmol/L in the perfusate, showed the usual blunted or no response to ss-adrenergic stimulation. Lowering [Ca(2+)] to 0.75 to 1.5 mmol/L unloaded the hearts of calcium and restored to nearly normal the responsiveness to ss-agonist stimulation.
