1.
Antimicrob Agents Chemother
; 43(4): 972-4, 1999 Apr.
Article
in English
| MEDLINE
| ID: mdl-10103214
ABSTRACT
The pharmacokinetic profile of oral zidovudine entrapped in a 50:50 polyactide-coglycolide matrix (nanospheres) was compared to those of standard oral and parenteral zidovudine formulations in rabbits. The bioavailability of zidovudine nanospheres at 50 mg/kg of body weight was 76%, and this dose achieved prolonged exposure to zidovudine compared to standard formulations without an increase in the drug's peak concentration.