ABSTRACT
A stable and easily reproducible model of experimental retinopathy was constructed in rabbits. The influence of transplanted neural stem cells (NSC) on the functional activity of the retina was studied. Retinopathy was provoked by 0.04 mg of kainic acid introduced intravitreously. The cultivated NSCs were transplanted into the vitreous bodies of the right (experimental) eyes, physiological solution was administered into the left (control) eyes. Clinical examinations of the eyeball in the experimental group showed less pronounced proliferative changes and a lack of gliosis, whereas, in the control group, the retina looked like tissue with fibrous changes and glial bars. An evaluation of the functional activity of the retina denoted a reliably better function of rod bipolars and Muller glias in the eyes with transplanted NSCs during the whole follow-up.
Subject(s)
Brain Tissue Transplantation , Neurons/transplantation , Retinal Diseases/surgery , Stem Cell Transplantation/methods , Animals , Cells, Cultured , Disease Models, Animal , Electroretinography , Humans , Rabbits , Retina/pathology , Retina/physiopathology , Retinal Diseases/pathology , Retinal Diseases/physiopathology , Transplantation, Heterologous , Treatment OutcomeABSTRACT
The clinical picture of an injury inflicted with gas pistols represents polymorphous changes and severe injury to the organ of vision, involving not only the anterior segment, but the deep structures as well. Analysis of the status of the damaged eyes and the mechanism of injury permitted us to distinguish 3 clinical groups in terms of the intensity of exposure to this or that factor: 1) chemical burn of the cornea and conjunctiva (65 patients); 2) chemical burn with elements of thermal involvement and impregnation of tissues with particles of gunpowder that failed to burn and slight or medium-severe contusion of the eyeball (31 patients): and 3) severe thermochemical burn with grave contusion of the eyeball, sometimes with rupture of membranes (6 patients). Hence, we may conclude that the consequences of using gas weapons differ from those described in the Status of Gas Weapons Application and in advertising materials by a much greater severity, and in 11.7% cases such injuries led to complete irreversible loss of vision. Obviously the shortest distance from which it may be allowed to shoot from gas pistols should be increased to 1 meter.
Subject(s)
Burns, Chemical/pathology , Conjunctiva/injuries , Corneal Injuries , Eye Burns/pathology , Eye Injuries, Penetrating/pathology , Firearms , Wounds, Gunshot/complications , Adolescent , Adult , Burns, Chemical/etiology , Conjunctiva/pathology , Cornea/pathology , Eye Burns/etiology , Eye Injuries, Penetrating/etiology , Female , Humans , Male , Retrospective Studies , Visual AcuitySubject(s)
Eye Injuries/chemically induced , Eye Injuries/therapy , Tear Gases/adverse effects , Burns, Chemical/etiology , Burns, Chemical/therapy , Combined Modality Therapy/methods , Eye Burns/chemically induced , Eye Burns/therapy , Facial Injuries/chemically induced , Facial Injuries/therapy , First Aid/methods , HumansABSTRACT
The authors analyze clinical features of injuries to the organ of vision under extreme conditions of a local war conflict and present their recommendations on rehabilitation of the victims. The status of 203 patients with eyeball wounds inflicted under such conditions is analyzed. To optimize the outcomes of war traumas to the eye inflicted in peace time the authors give the following recommendations based on the specific features of such injuries and the objective conditions in foci of regional conflicts: (1) Rapid evacuation of wounded subjects to the nearest ophthalmological institutions; (2) Maximally early primary ophthalmological care with obligatory primary surgical debridement of the wound; (3) No attempts at removal of a foreign body during primary surgical debridement at local medical institutions; (4) the earliest possible evacuation of the victims after wound debridement to specialized ophthalmo-traumatological institutions for further rehabilitation.
Subject(s)
Eye Injuries , Warfare , Adult , Child , Commonwealth of Independent States , Explosions , Eye Foreign Bodies/etiology , Eye Foreign Bodies/therapy , Eye Injuries/etiology , Eye Injuries/therapy , Female , Humans , Male , Trauma Centers , Wounds, GunshotABSTRACT
The authors analyze the results of treatment of patients whose organ of vision was injured in accident. They point out a complex of measures promoting a relatively favorable optic and cosmetic outcome of injuries and discuss the shortcomings of ophthalmologic service. Various aspects of the problem are considered to develop practical recommendations on effective care of the injured patients.
