Aneurysmal cyst, bone type, primary in an artery.

An aneurysmal bone cyst-like reaction involving the left common carotid artery bifurcation in an otherwise healthy 7-year-old boy is described. The patient presented with a 6-week history of an enlarging pulsatile neck mass. The mass was excised with connection of arteries on either side with a saphenous vein graft. There were no associated intracranial arterial aneurysms or associated skeletal lesions. A history of trauma could not be elicited. To the best of our knowledge this is the first report of an aneurysmal cyst, bone type, involving a large blood vessel.

The sinus lift procedure: an alternative to the maxillary subperiosteal implant.

Technical advances now allow implants to be placed when pneumatization of the sinus has left insufficient bone to engage an endosseus implant. Augmenting material, such as a mixture of resorbable hydroxylapatite and demineralized freeze-dried bone, is grafted into the sinus cavity. This creates a new alveolar ridge to support endosseous implants.

Fatal small intestinal infarction due to occlusion by mesenteric carcinoid tumor.

A case of sudden death due to massive small intestinal infarction is reported. The cause of the intestinal infarction was occlusion of mesenteric vessels by massive fibrosis secondary to carcinoid tumor. Since no primary carcinoid tumor was found in the intestine or elsewhere, it is suggested that the carcinoid tumor had originated in the mesentery.

Monoclonal antibody against a cryptic carbohydrate antigen of murine and human lymphocytes. I. Antigen expression in non-cryptic or unsubstituted form on certain murine lymphomas, on a spontaneous murine mammary carcinoma, and on several human adenocarcinomas.

This paper describes an IgM monoclonal antibody (49H.8) which was produced following immunization of BALB/c mice with human neuraminidase-treated erythrocytes (NE-RBC). 49H.8 reacts with NE-RBC, neuraminidase-treated T lymphocytes (NE-T) and NE B lymphocytes of both human and murine origin. Little or no reactivity with untreated T or B cells could be detected. Thus the 49H.8 antigen is "cryptic" in most normal lymphocytes of both humans and mice. In contrast, the 49H.8 antigen was detected in non-cryptic or unsubstituted form on many non-treated murine lymphomas of both B- and T-cell origin, on the spontaneous murine mammary carcinoma, TA3-HA and on several human adenocarcinomas. The 49H.8 antigen appears to be related to the previously described 49H.24 antigen as shown by sugar inhibition experiments. 49H.24 reacts most strongly with the synthetic disaccharide (betaGa1 (I leads to 3)alpha Ga1NAc) but not at all with beta Ga1(I leads to 3)beta Ga1Nac. 49H.24 does not react with any of the murine or human tumors tested. 49H.8 reacts with both the alpha and beta forms of the disaccharide but reacts most strongly with phenyl-beta-galactoside-containing compounds. In contrast, phenyl-alpha-galactoside-containing compounds produced no reaction. The natural determinant detected by this antibody was not determined but various possibilities are considered. 49H.8 was used to detect antigen apparently shed from growing TA3-Ha cells into the serum and ascites of tumor-bearing mice. These observations suggest that the 49H.8 monoclonal antibody will be valuable as a specific reagent for a common tumor-associated antigen shared by certain murine and human tumors, and as a means of assaying shed tumor antigen in circulation as in the TA3-Ha mammary adenocarcinoma model.

Leydig cell hypogenesis: a rare cause of male pseudohermaphroditism and a pathological model for the understanding of normal sexual differentiation.

We describe a patient who presented for treatment of primary amenorrhea and was found to have male pseudohermaphroditism due to Leydig cell hypogenesis. This rare disorder is characterized by ambiguous genitalia with a normal clitoris, labioscrotal folds, a urogenital sinus and inguinal or intra-abdominal testes microscopically devoid of mature Leydig cells. The diagnosis is made biochemically by the presence of low testosterone and estradiol values with elevated luteinizing hormone levels in the absence of other significant hormonal changes. The clinical and laboratory features of this disorder offer support for human developmental concepts derived from animal models.

Primary and secondary healing in infected wounds. An experimental study.

The beneficial effects of delayed closure of contaminated wounds are recognized, but not well defined. Rats with abdominal incisions were infected with Staphylococcus aureus or Escherichia coli and then subgrouped for primary or secondary healing. Noninfected rats served as controls. Between seven and 119 days later, the wounds were subjected to breaking-strength determination, hydroxyproline analysis, and light and scanning electron microscopy. In the controls, secondary closure gave stronger wounds than primary closure. In those infected with S aureus the wounds were stronger than in the primary-closure control group, regardless of the closure method. Of the E coli-infected wounds those primarily closed were weaker than those secondarily closed. Secondary closure gave infected wounds fewer complications. Biochemical and microscopic examination did not explain these findings.