ABSTRACT
The gestagenic activity of new 17alpha-hydroxyprogesterone analogs was studied in experiments on infantile female rabbits (Clauberg-McPhail assay) and ovariectomized animals (Comer-Allen assay). The new steroidal preparations produced significant secretory transformations in immature rabbit endometrium. The maximum gestagenic activity was observed for butagest, while the minimum effect was produced by duhydrogesterone (dufaston). Butagest, megestrol capronate, and AMOL isopropyl ester showed the ability to maintain pregnancy in ovariectomized female rabbits. The compositions of gestagens (0.8 mg/kg) with ethinylestradiol (0.04 mg/kg) produced high contraceptive effect in rats.
Subject(s)
Contraceptives, Oral/administration & dosage , Endometrium/metabolism , Pregnancy, Animal/drug effects , Progesterone Congeners/administration & dosage , Animals , Dose-Response Relationship, Drug , Female , Pregnancy , Rabbits , RatsABSTRACT
Experiments on infantile female rabbits showed that new 17a-hydroxyprogesterone derivatives (AMOL phenyl propionate, AMOL isopropyl ester) possess a pronounced gestagenic activity. In particular, AMOL isopropyl ester is capable of maintaining pregnancy in ovariectomized animals (Corner-Allen assay).
Subject(s)
17-alpha-Hydroxyprogesterone/analogs & derivatives , 17-alpha-Hydroxyprogesterone/pharmacology , Pregnancy, Animal/drug effects , Progesterone Congeners/pharmacology , Animals , Dydrogesterone/pharmacology , Esters , Female , Ovariectomy , Pregnancy , RabbitsABSTRACT
The ability of a series of new 17 alpha-Hydroxyprogesteron derivatives (acetomepregnol, AMOL phenyl propyoate, butagest) in preventing the prostaglandin-induced preterm labor was experimentally studied in mice. It was found that all the synthetic gestagens studied, especially butagest, maintained pregnancy in all test animals on the model of enzaprost F induced abortion. The proposed progestogens can be used to prevent abortion in pregnancies in cases of risk from diseases connected with excess prostaglandin secretion.
Subject(s)
Obstetric Labor, Premature/prevention & control , Progesterone/analogs & derivatives , Progesterone/therapeutic use , Abortifacient Agents, Nonsteroidal , Abortion, Induced , Animals , Dinoprost , Female , Mice , Obstetric Labor, Premature/chemically induced , PregnancyABSTRACT
The effect of instenon upon the uterine contractile activity was studied in pregnant rats. The drug administration at a dose resulted in significant suppression of the myometrium contractility. The effect was not decreased when instenon was injected against the background of oxytocin. On the other hand, the concurrent injection of oxytocin upon a single or long-term administration of instenon produced a pronounced stimulating action on the myometrium contractility.
