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Progressive Multifocal Leukoencephalopathy after Treatment with Nivolumab.

Martinot, Martin; Ahle, Guido; Petrosyan, Inesa; Martinez, Camille; Gorun, Dragos M; Mohseni-Zadeh, Mahsa; Fafi-Kremer, Samira; Tebacher-Alt, Martine.

Emerg Infect Dis ; 24(8): 1594-1596, 2018 08.

Article in English | MEDLINE | ID: mdl-30016251

ABSTRACT

Progressive multifocal leukoencephalopathy (PML) is increasingly being reported in patients undergoing immunotherapy. We report a case of progressive multifocal leukoencephalopathy after treatment with nivolumab, a PD-1 blocker that is used to restore impaired T-cell responses in patients with cancer and infections. Data for 4 other cases were obtained from pharmacovigilance databases.

Subject(s)

Antineoplastic Agents, Immunological/adverse effects , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Hodgkin Disease/drug therapy , Leukoencephalopathy, Progressive Multifocal/etiology , Nivolumab/adverse effects , Viremia/etiology , Aged , Antineoplastic Agents, Immunological/administration & dosage , Female , Hodgkin Disease/diagnostic imaging , Hodgkin Disease/pathology , Hodgkin Disease/virology , Humans , Hydrocortisone/therapeutic use , JC Virus/isolation & purification , Leukoencephalopathy, Progressive Multifocal/diagnostic imaging , Leukoencephalopathy, Progressive Multifocal/pathology , Leukoencephalopathy, Progressive Multifocal/virology , Magnetic Resonance Imaging , Male , Middle Aged , Nivolumab/administration & dosage , Programmed Cell Death 1 Receptor/antagonists & inhibitors , Programmed Cell Death 1 Receptor/genetics , Programmed Cell Death 1 Receptor/immunology , Viremia/diagnostic imaging , Viremia/pathology , Viremia/virology

ABSTRACT

Subject(s)

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