[Comparative rheoencephalographic and convective radiation encephalic thermometric studies]. / Sravnitel'nye reoéntsefalograficheskie i radiatsionno-konvektsionnye éntsefaloteplometricheskie issledovaniia.

It is for the first time that thermoassimetry of heart flows of brain right and left hemispheres presenting as predominance of radiative-convective heat radiation from the left has been revealed, the thermoassimetry gradient being rostral-caudal. Disclosed in cerebral hemispheres was complimentarity of energetic processes: the right hemisphere secures the background energy state, the left one functions in ensuring the discrete adaptive thermoenergy reactions. The thermoassimetry revealed may be the basis of other functional asymmetries of the brain. There was no parallelism between the studied parameters of circulation and heat flow.

[Radiant-convection heat flow studied during the performance of a mud therapy procedure]. / Issledovanie radiatsionno-konvektsionnogo teplovogo potoka pri provedenii griazelechebnoi protsedury.

Original technique is described of recording radiative convective heat flow- (RCHF) over various sites of the patient's body surface while he or she is receiving a mud treatment. The dynamics of the RCHF in the course of applying mud to the patient is demonstrated, which is best recorded over the surfaces of the forehead and hands. The proposed technique permits the objectivization of thermoenergetic response of the organism to thermal therapeutic interventions to be done.

[The use of the multivariate estimation method for the objective evaluation of the effect of antihypoxic therapy in the first 24 hours after an absolutely lethal radiation injury]. / Primenenie metoda mnogomernogo otsenivaniia dlia ob''ektivizatsii vliianiia antigipoksicheskoi terapii v pervye sutki posle absoliutno letal'nogo luchevogo porazheniia.

Three groups of rats (intact, irradiated with 30 Gy of gamma rays and treated after irradiation with the use of pharmacological and metabolic drugs protecting brain against hypoxia were studied. In 24 hours after the influence the animals have undergone the neurobehavioral testing and then were sacrificed, a number of neurochemical parameters depicting energy metabolism and metabolic GABA bypath in brain were studied (general number of parameters were 24). Using classical method of t-statistics only enhancement of labelled GABA catabolism and deterioration of general behavioral activity were verified, the modifying effect of the pharmacological and metabolic protection against hypoxia was not found. Using methods of multidimensional evaluation the protective and sanogenic character of the used method of therapy was verified. Thus, using discrimination analysis (Mahalanobis criterion) high similarity of intact and treated groups of animals was estimated. It was confirmed using methods of coupled and multiple correlation and method of route coefficients. The statistical connections between neurochemical and neurobehavioral parameters were found which can be useful for understanding of the mechanisms of the early postradiation syndrome development.

[Meiosis in Pleurotus florida Fovose]. / Meioz u veshenki floridskoi (Pleurotus florida Fovose).

It is stated that the meiosis of Pleurotus florida differs from the classical one. The condensation chromosomes conjugate in metaphase I.

[Cavinton in the prevention of the convulsive syndrome in children after birth injury]. / Kavinton v profilaktike sudorozhnogo sindroma u detei, perenesshikh rodovuiu travmu.

The authors studied the efficacy of cavinton as an agent helpful in preventing neurologic disorders in the newborn with hypoxic ischemic encephalopathy due to intracranial birth trauma. The short-term results of the treatment were elucidated in 61 children. In group I including 20 persons given conventional therapy, the disappearance of seizures was recorded in 6 patients; out of 41 children (group II) given additionally cavinton, in 27. Twenty-nine children were followed up for a year. In group I, convulsive paroxysms recurred in 4 patients, whereas in the group II children, no convulsive syndrome was recorded on the follow-up. The group II children also showed a decrease of the phenomena of intracranial hypertension and normalization of the psychomotor development. The preventive effect of cavinton seen in children with a history of birth trauma may be accounted for by its capacity of normalizing cerebrovascular disorders and by its own anticonvulsive properties.

[Effect of Cavinton on convulsions caused by chemical substances]. / Vliianie kavintona na sudorogi, vyzvannye khimicheskimi veshchestvami.

Cavinton was shown to protect mice against convulsions induced by corazol, strychnine and thiosemicarbazide. In addition, cavinton exhibited a definite antagonism to convulsive reactions produced by systemic administration of penicillin to cats and a combined administration of penicillin (intramuscularly) with tryptophan metabolite, quinolinic acid (intracerebroventricularly). The anticonvulsant action of cavinton is suggested to be due to the involvement of the brain GABA- and serotonergic mechanisms. It is reasonable to test cavinton as a drug for treating some forms of epilepsy.

[Use of cavinton in epilepsy]. / O primenenii kavintona pri épilepsii.

The authors studied the effect of cavinton (15-45 mg/day) and its combinations with different anticonvulsants on the time-course of different forms of epilepsy. In 20 of the 31 patients studied treatment with cavinton either significantly decreased the frequency of attacks or led to their complete disappearance; in 7 patients the improvement was insignificant and in 4 the condition deteriorated. The greatest effect of cavinton was observed in generalized tonic-clonic convulsions and when they were combined with absences. Clinical improvement not always correlated with EEG normalization. A suggestion is made that the mechanism of the anticonvulsive action of cavinton may be explained both by the normalization of the cerebral blood flow and elimination of hypoxia and by the fact that the drug may possess anticonvulsive properties unrelated to the normalization of the cerebral hemodynamics.

[Experimental verification of several assumptions and methods of statistical genetics. II]. / Eksperimental 'naia proverka nekotorykh predpolozhenii i metodov statisticheskoi genetiki. Soobshchenie II.

The applicability of A. S. Serebrovsky's formulas and N. A. Sobolev's methods was investigated for a dihybrid cross. It was shown that Serebrovsky's formulas do not always lead to a correct estimation of the minimal number of genes by which the parents are distinguished. In the case of gene interaction this estimation sometimes proved to be exaggerated 2-4 times. A test of Sobolev's method demonstrated that this method cannot be considered as reliable for work. Most of his estimations are not correct. Various estimations of the same phenomenon are often contradictory.

[Effect of acid polysaccharides on the corticosteroid biosynthesis]. / Vliiani kislykh polisakharidov na biosintez kortikosteroidov.

Repeated administration of carboxymethylchitin and chondroitinsulfate to rats in doses of 20 and 120 mg/kg/24 hours led to reduction (by 40-55%) of the rate of aldosterone and 18-oxycorticosterone biosynthesis by the rat adrenal glands in vitro. Carboxymethylcellulose, algin and hyaluronic acid displayed no inhibitory effect. In case of a single administration of carboxymethylchitin to rats (50 mg/kg) inhibition of the rate of aldosterone and 18-oxycorticosterone biosynthesis was seen 48 hours after the administration of the preparation and lasted four days. No inhibitory effect was induced by the addition of 10 mg/kg of acid polysaccharides into the incubation medium of the adrenal glands.

[Torsion movements of the human eye. III. Rapid phase of torsion]. / Issledovanie torzionnykh dvizhenii glaz cheloveka. III. Bystraia faza torzii.

Kinematic characteristics of torsional saccades and their peculiarities were investigated. The torsional saccades were found to occur simultaniously in both eyes and had the same size and duration. It was shown that the peak velocity and the duration of the saccades depend on their amplitudes. The number of the saccades decreased and their sizes increased when the head tilts were faster. In the case intervals between the saccades decreased up to 20-30 ms. The likeness of the torsional movements and rotatory nistagmus was discussed.

[Torsional movements of the human eye. II. Slow phase of torsion]. / Issledovanie torzionnykh dvizhenii glaz cheloveka. II. Medlennaia faza torzii

At different experimental conditions quantitative characteristics of the slow phase of the torsional eye movements were investigated. We found the torsional drift to increase when the head tilted faster and its velocity was bigger in the dark than in the light. Asymmetry of the drift velocity was found on moving the head to and backward. It was shown that the sign of the asymmetry did not depend on rotatory movements of the cup (the suction device for eye movement registration). At the same time electric stimulation of the labyrinth changed the sign of asymmetry and without head tilting led to the torsional eye movements (nistagmus). Some subjects were able to decline the number of the torsional saccades at will, and as a result the eye made a drift up to tens of degrees long. Possible causes of imperfect vestibular and optokinetic compensation in the eye trosion were discussed.

[Torsional movements of the human eye. I. Torsional movements on inclining the head towards the shoulder]. / Issledovanie torzionnykh dvizhenii glaz cheloveka. I. Nekotorye osobennosti torzionnykh dvizhenii pri naklone golovy k plechu

The characteristics of the torsional eye movements during head tilting were investigated. Different conditions were used in the experiments. The subjects were in sitting and lying positions in the light and in the dark. A new method of recording with the suction device of Yarbus and the simple optical system allowed to have records without some redundant components of movement. This made record processing less complex and more accurate. The torsional drift in the slow phase of the eye movement was found present under any conditions. When being recorded simultaneously both eyes in man were in identical and synchronous movement.

[Change in aldosterone secretion by the adrenals and in its urinary excretion in rats under the action of acid polysaccharides]. / Izmenenie sekretsii al'dosterona nadpochechnikami i ékskretsii ego s mochoi u krys pri vozdeistvii kislykh polisakharidov

Repeated administration of chondroitin sulfate to rats in doses of 20 and 120 mg/kg/24 hours led to reduction in the level of urinary aldosterone excretion in rats. Carboxymethylcellulose and alginic acid displayed no inhibitory effect. Urinary aldosterone excretion decreased in rats 24 hours after a single administration of chondroitin sulfate; this effect persisted for the following 3-4 days. The maximal reduction of aldosterone excretion (by 50%) occurred on the 3rd and the 4th day after administration of the preparation. Intraperitoneal injection of chondroitin sulfate to rats diminished the rate of aldosterone secretion by the adrenal glands; as to corticosterone secretion--it remained unchanged.