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1.
Orv Hetil ; 160(24): 952-957, 2019 Jun.
Article in Hungarian | MEDLINE | ID: mdl-31433234

ABSTRACT

We report a case of a 41-year-old female patient presenting with watery diarrhoea and myalgia in the winter-season. Before her symptoms started she had participated in a pig slaughtering with her family. Some of the family members also became ill. On her physical examination periorbital odema and myalgia were found. Eosinophilia, hypalbuminaemia, elevated lactate dehydrogenase and creatin kinase levels were detected on laboratory investigations. The clinical picture, the laboratory findings and background epidemiological data implied the diagnosis of trichinellosis and albendazol was started. Serum gained on the 22nd post-infectious day turned out to be equivocal for trichinellosis. For this reason and because of the refractory fever a muscle-biopsy was done. Granulomatous myositis described by histology and Trichinella seropositivity from the repeated serum sample on the 62nd post-infectious day finally confirmed the diagnosis. During the course of the disease, we experienced elevation of troponin I suggesting myocarditis, but it was accompanied neither with abnormal ECG signs nor characteristic symptoms. Almost a century ago, a case report was published in Hungarian with a similar introduction. Trichinellosis in that epidemic setting led to the death of five people. Orv Hetil. 2019; 160(24): 952-957.


Subject(s)
Diarrhea/etiology , Fever/etiology , Myalgia/etiology , Myositis/etiology , Trichinella/isolation & purification , Trichinellosis/diagnosis , Adult , Albendazole/therapeutic use , Animals , Anthelmintics/therapeutic use , Eosinophilia/etiology , Female , Humans , Muscle, Skeletal/parasitology , Myositis/drug therapy , Myositis/parasitology , Seasons , Swine , Treatment Outcome , Trichinellosis/blood , Trichinellosis/drug therapy
2.
Best Pract Res Clin Rheumatol ; 18(5): 663-76, 2004 Oct.
Article in English | MEDLINE | ID: mdl-15454125

ABSTRACT

Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder of unknown etiology and pathogenesis. AOSD is a rare condition, usually presenting with high fever accompanied by systemic manifestations. The disease is a heterogeneous pathological entity with a range of etiologies, manifestations and prognosis. There is no single diagnostic test for AOSD; rather, the diagnosis is based upon clinical criteria such as arthralgia, fever, skin rash, lymphadenopathy, and hepatosplenomegaly. Determination of the procalcitonin level and the biological response to empirical corticosteroid therapy generally helps the diagnosis, while immune-serology, as a 'screening' test, will not add meaningful information in most cases. Treatment consists of anti-inflammatory medications. Non-steroid anti-inflammatory drugs have limited efficacy, corticosteroid therapy and disease-modifying antirheumatic drugs are usually required. Novel therapeutic approaches, such as anti-tumor necrosis factor blockade and stem cell transplantation, are promising. In this chapter we present clinical and laboratory parameters of 18 patients diagnosed with AOSD at our institution between 1997 and 2003, and review the literature.


Subject(s)
Still's Disease, Adult-Onset , Adult , Female , Fever of Unknown Origin/etiology , Humans , Male , Still's Disease, Adult-Onset/complications , Still's Disease, Adult-Onset/pathology , Still's Disease, Adult-Onset/therapy
4.
Int J Dermatol ; 42(11): 898-902, 2003 Nov.
Article in English | MEDLINE | ID: mdl-14636209

ABSTRACT

A 59-year-old male patient developed a necrotizing ulceration on the right shin. Both clinical and histopathologic examinations suggested pyoderma gangrenosum. After temporary improvement of skin symptoms under peroral glucocorticoid treatment, a hemorrhagic-purulent discharge started from the nose, he began to have fever, malaise, cough, and a chest X-ray revealed inflammation in the lung. Cerebral CT and MRI disclosed midline bone loss within the nasal septum and granulomatosus tissue masses protruding into the right orbit. The c-ANCA test was positive, serum IgA was elevated, and he had microhaematuria and proteinuria. In this severe case of Wegener's granulomatosis prolonged methylprednisone and cyclophosphamide treatment was initiated. Both the skin symptoms and the granulomatosus infiltrations resolved.


Subject(s)
Granulomatosis with Polyangiitis/complications , Pyoderma Gangrenosum/etiology , Granulomatosis with Polyangiitis/pathology , Granulomatosis with Polyangiitis/therapy , Humans , Male , Middle Aged , Pyoderma Gangrenosum/pathology , Pyoderma Gangrenosum/therapy
5.
Orv Hetil ; 144(4): 173-8, 2003 Jan 26.
Article in Hungarian | MEDLINE | ID: mdl-12621815

ABSTRACT

INTRODUCTION: Adult onset Still's disease (juvenile rheumatoid arthritis with septic appearance) is rare, leading to clinical signs similar to those seen in bacterial sepsis, lymphomas, rheumatological, or systemic autoimmune diseases. The disease can present with a fever of unknown origin, and can cause difficulties in the diagnosis. It is based upon, partly, the exclusion of other diseases and on diagnostic criteria. Its characteristic feature is the rise of acute phase proteins. Exanthemata are temporary. The basis of treatment is immunosuppression, however relapses can occur. AIM: The aim of the authors was to evaluate on the most characteristic clinical signs and laboratorical data of their patients, and to examine the revealing parameters of the course of the disease. METHOD: Retrospective epidemiological survey of the data obtained from 18 patients. RESULTS: The characteristic signs of the disease were, fever, sore throat, arthritis, joint pain, exanthemata, hepato-splenomegaly, lymphadenomegaly, pleurisy. The typical laboratorical data were: elevated CRP, low PCT, negative Waaler-Rose and ANA test, low serum iron level, leukocytosis, thrombocytosis, elevated alkalic phosphatase activity, high LDH, positive bone scintigraphy. The fever was steroid dependent. Generally, the illness was recognised after 2-3 months, and relapses were frequent. CONCLUSIONS: Still's disease has an important role in the differential diagnosis of fever of unknown origin. The diagnosis is based upon the evaluation of clinical signs and laboratorical data together. Prolonged immunosuppressive therapy is required.


Subject(s)
Still's Disease, Adult-Onset/diagnosis , Still's Disease, Adult-Onset/epidemiology , Adult , Arthritis/etiology , Diagnosis, Differential , Female , Fever of Unknown Origin/etiology , Humans , Hungary/epidemiology , Male , Middle Aged , Prognosis , Retrospective Studies , Risk Factors , Still's Disease, Adult-Onset/complications , Still's Disease, Adult-Onset/etiology
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