ROLE OF BIOLOGICAL MARKERS IN DIAGNOSIS OF PURULENT­SEPTIC COMPLICATIONS OF AN ACUTE NECROTIC PANCREATITIS.

Examination and treatment of 70 patients, suffering an acute necrotic pancreatitits, was conducted. Content of presepsin, procalcitonin, С­reactive protein and interleukin­6 (ІL­6) in the patients' blood plasma was determined, and bacteriological investiga' tions, contrast­enhanced CT were conducted as well. Positive results of bacteriologi' cal investigations were noted in 43 patients. Level of presepsin and procalcitonin in patients, suffering purulent­septic complications, in 3 ­ 4 times exceeded such in a sterile pancreonecrosis. Presersin level,exceeding over 632 pg/ml, have permitted to confirm the presence of local and systemic infection with high specificity and sensitivi' ty, and this have exceeded diagnostic possibilities of the procalcitonin content determi' nation. High level of ІL­6 and С­reactive protein is characteristic for the systemic inflammatory response syndrome (SIRS) of infective and noninfective origin.