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Kuznetsova, S A; Petrukov, K S; Pletnev, F I; Sergiev, P V; Dontsova, O A.

Biochemistry (Mosc) ; 84(8): 851-869, 2019 Aug.

Article in English | MEDLINE | ID: mdl-31522668

ABSTRACT

The review summarizes the data on pro- and eukaryotic RNA (C5-cytosine) methyltransferases. The structure, intracellular location, RNA targets, and catalytic mechanisms of these enzymes, as well as the functional role of methylated cytosine residues in RNA are presented. The functions of RNA (C5-cytosine) methyltransferases unassociated with their methylation activity are discussed. Special attention is given to the similarities and differences in the structures and mechanisms of action of RNA and DNA methyltransferases. The data on the association of mutations in the RNA (C5-cytosine) methyltransferases genes and human diseases are presented.

Subject(s)

5-Methylcytosine/metabolism , Methyltransferases/chemistry , Methyltransferases/physiology , RNA Processing, Post-Transcriptional/physiology , 5-Methylcytosine/chemistry , Amino Acid Sequence/genetics , Animals , DNA (Cytosine-5-)-Methyltransferases/genetics , DNA (Cytosine-5-)-Methyltransferases/physiology , Humans , Methylation , Methyltransferases/genetics , Mice , Mutation , Phylogeny , Protein Structure, Secondary , RNA, Transfer/genetics , RNA, Transfer/metabolism , tRNA Methyltransferases

ABSTRACT

Subject(s)

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