ABSTRACT
The levels of spontaneous and mitogen-induced production of pro- and anti-inflammatory cytokines were studied in patients with chronic lymphoid leukemia, non-Hodgkin's lymphocytic lymphomas, and multiple myeloma during the course of chemotherapy. Cytokine concentrations varied within a great range and did not conform to the normal distribution law. The levels of granulocyte and granulocyte-macrophage CSF were high during the debut, progress, and remission of the lymphoproliferative diseases. Imbalance of a wide spectrum of pro- and anti-inflammatory cytokines was observed during the debut and progress of the lymphoproliferative diseases, more often in chronic lymphoid leukemia and non-Hodgkin's lymphocytic lymphomas than in multiple myeloma.
Subject(s)
Cytokines/blood , Granulocyte Colony-Stimulating Factor/blood , Granulocyte-Macrophage Colony-Stimulating Factor/blood , Leukemia, Lymphoid/blood , Lymphoma, Non-Hodgkin/blood , Multiple Myeloma/blood , Aged , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Case-Control Studies , Female , Humans , Inflammation Mediators/blood , Leukemia, Lymphoid/drug therapy , Leukemia, Lymphoid/immunology , Lipopolysaccharides/pharmacology , Lymphoma, Non-Hodgkin/drug therapy , Lymphoma, Non-Hodgkin/immunology , Male , Middle Aged , Mitogens/pharmacology , Multiple Myeloma/drug therapy , Multiple Myeloma/immunologyABSTRACT
Here we present the results of pathomorphological study of erythron cells from patients with indolent non-Hodgkin lymphomas and multiple myeloma. The revealed associations suggest that tumor cells can modulate the bone marrow and peripheral compartment of the erythron in lymphoproliferative diseases leading to quantitative and morphological changes in bone marrow erythrokaryocytes and peripheral blood erythrocytes. Clinical and pathomorphological markers of dyshemopoiesis associated with the presence of anemia were identified in indolent non-Hodgkin lymphomas. In multiple myeloma, a correlation between the parameters of bone marrow and peripheral compartments of the erythron and structural modifications of myeloma cells infiltrating the bone marrow was revealed.
Subject(s)
Bone Marrow/pathology , Erythroid Cells/cytology , Lymphoma, Non-Hodgkin/pathology , Multiple Myeloma/pathology , Aged , Analysis of Variance , Cytological Techniques , Female , Humans , Male , Middle AgedABSTRACT
Morphometric study of the erythroid stem was performed in aggressive and indolent non-Hodgkin's lymphomas vs. other cells and tissues of the bone marrow (including the tumor tissue) before chemotherapy. Hypoplasia and abnormal maturation of the erythroid stem were particularly pronounced in diffuse infiltration of the bone marrow, which did not depend on lymphoma aggressiveness. Hypoplasia of the erythroid stem was often observed during focal infiltration of the bone marrow with lymphoma cells (despite a smaller area of tumor tissue in aggressive lymphomas than in indolent lymphomas). A decrease in the relative area of adipose tissue, smooth resorption of bone tissue, and myelofibrosis are the major changes in the bone marrow microenvironment.
Subject(s)
Bone Marrow/pathology , Lymphoma, Non-Hodgkin/pathology , Adult , Aged , Biopsy , Female , Humans , In Vitro Techniques , Male , Middle AgedABSTRACT
Structural changes in cells of the central compartment of the erythron depended on tumor infiltration of the bone marrow. Cytostatic therapy was shown to improve quantitative indexes, but had no effect on morphological characteristics of the erythron. Examination of trepanobiopsy specimens from the iliac crest during chemotherapy revealed the existence of specific relationships between the erythron, other cells and tissues of the bone marrow, and tumor. Significant changes in the erythron were found during diffuse tumor infiltration and treatment with anthracycline antibiotics.
