COMPARISON OF THE IMPACT OF ANTISEPTIC AGENTS ON GARDNERELLA VAGINALIS AND ATOPOBIUM VAGINAE DETECTED IN THE ORAL CAVITY OF WOMEN WITH BACTERIAL VAGINOSIS.

When women with comorbid bacterial vaginosis visit periodontologist, it is essential to understand the presence of cross-infection processes between the oral cavity and vagina in this particular category of subjects. Conducting detection of Gardnerella vaginalis and Atopobium vaginae, which are provocative microbial factors for bacterial vaginosis, is a mandatory step in the laboratory examination of subjects. When choosing an antiseptic for oral cavity disinfection, the use of 0.25% dequalinium chloride is more advisable. Both subjective and objective examination methods thoroughly demonstrate the higher clinical effectiveness of 0.25% dequalinium chloride: patients report a 20% more frequent improvement in subjective indicators, the index assessment of periodontal status improves by 1.2-1.6 times, and the detection rate of Gardnerella vaginalis and Atopobium vaginae is by 20% lower compared to 0.2% chlorhexidine. The specific composition of oral microbiota in this group of subjects necessitates adjustments to treatment protocols and consideration of the specific impact on Gardnerella vaginalis and Atopobium vaginae.

CLINICAL AND HAEMATOLOGICAL CHANGES AMONG HIV PATIENTS.

This is an article about anemia of chronic diseases in HIV patients. It follows a study of the nature of red blood cells changes in patients with HIV infection and the features of anemia of chronic diseases (ACD) in the particular group of patients. In addition, connection was established between changes in oral cavity and peripheral blood parameters. The study identified clinical signs of anemia in maxillofacial area and oral cavity in HIV-infected people. During the analysis of red blood cell indicators in patients with HIV a number of changes were observed. The problem of anemia in this group was complicated by the patients taking highly active antiretroviral therapy (ART). The study revealed significant changes in red blood cell count in people with HIV status, who were either taking or not taking highly active ART. We also analyzed the studied parameters of red blood cells in patients with HIV infection, depending on level of blood lymphocytes with CD4 cluster differentiation in plasmolemma, and depending on the stage of the main disease. We also analyzed and studied parameters depending on the state of periodontal tissues. Identified results can be interesting in terms of establishing pathogenetical relationships in development of inflammatory and degenerative changes in periodontal tissues and anemia of chronic diseases associated with HIV infection. These findings require further investigation and more comprehensive analysis.

[Dynamics of dental status of pregnant women in conjunction with their vegetative and psycho-emotional performance].

The aim of this study was to investigate the dynamics of the dental status in relation to the vegetative and psycho-emotional changes in women in the 1st, 2nd, and 3rd trimester of pregnancy. Dental and clinical neurological examination was conducted to study psycho-emotional and vegetative status of 51 pregnant women aged 19-36 years, who were registered in the antenatal clinic of Poltava. The analysis of the relationship between dental indicators, vegetative and psycho-emotional status of women in the 1st, 2nd, and 3rd trimester of pregnancy are presented. Analysis of the results showed that in women in the 3rd trimester the index values of DMF and PMA grow. Despite the evidence that oral health worsens in the 3rd trimester good oral health is maintained. The vegetative function of the body and a high level of adaptive-compensatory capacity of the organism are maintained. The revealed changes of dental health, features of autonomic regulation and psycho-emotional status of pregnant women should be considered when planning dental preventive measures.

[The screening diagnostic of micro ecological disorders of oral cavity].

The original mode of screening evaluation of colonizational resistance of oral cavity made it possible to detect its decreasing under caries of teeth solid tissue and development of catarrhal gingivitis. In springtime, the degree of failure of primarily barrier mechanism of oral mucous membrane increases.

[Condition of periodontal tissue in women with bacterial vaginosis].

Cross colonization of open cavities of human body has little been studied in contemporary medicine. There in no practical recommendations as for management of dental patients with urogenital tract microflora disorder. The paper presents the findings of clinical features of periodontium tissues in women with bacterial vaginosis correlated with bacteriological estimation of oral cavity and vagina, number of sexual partners. Interpretation of amine test of oral and vaginal fluids has been provided for the first time. Chronic generalized inflammatory and inflammatory-dystrophic periodontal diseases of different severity have been detected in all female patients with gynecological diagnosis of bacterial vaginosis. Gardnerella vaginalis, which is atypical representative of oral cavity microflora, has been detected by the PCR method in bacterial vaginosis both in vagina and oral cavity. The major markers of bacterial vaginosis have been also detected in oral cavity in women with this pathology.

[Biomechanical basis splinting of loose teeth while preserving their mobility at physiological].

The aim of this study was biomechanical rationale for splinting mobile teeth with periodontitis according to the height and slope of teeth crowns, their degree of mobility, and type of occlusion. The research studied the effect of axial vertical and horizontal loads on the functioning of the proposed method of splinting. Set clear indications and contraindications for the use of the method of splinting. Biomechanically proven unreasonableness includes teeth with III degree of mobility in the splinted construction. Clinical variant of splinting is only possible at the height of the anatomical crowns of the teeth of at least 7 mm, otherwise the preferred laboratory methods for the manufacture of tires.

[Role of oral cavity colonization resistance in dental caries development].

Colonization resistance is one of local immunity mechanisms determined by a combination of factors that inhibit the adhesion and growth of mucous membrane bacteria. We examined patients with different levels of caries intensity assessing oral mucosa colonization resistance by our own method. Caries development resulted in changes of colonization resistance with the increased rate of inhibition of the oral mucosa colonization resistance barrier.

[The pathogenetic mechanisms of the correlation of stress damage to the periodontium and the stomach]. / Patohenetychni mekhanizmy koreliatsiï stresornoho poshkodzhennia parodonta ta shlunka.

Using the model of immobilizing stress it has been established the correlation of changes of proteolytic enzymes, the level of neuramin acid and the structural violations of parodontium and stomach. There was made a conclusion about high sensitivity of both parts of digestive system to stress factors which realise their parallel damage.

[The dependence of the connective tissue reaction to stress on typological body characteristics]. / Zavisimost' reaktsii soedinitel'noi tkani na stress ot tipologicheskikh svoistv organizma.

The experiment on 52 Wistar rats was made to study dependence of connective tissue reactions on typological properties of the body. The type of the reaction is closely related with the degree of changes in connective tissue structures of the digestive organs (periodontium, stomach) and the lungs. Acute stress stimulates degradation of the noncollagen proteins of the connective tissue main substance.

[Effect of adaptation to short-term stresses on periodontal tissue resistance to acute stress]. / Vliianie adaptatsii k korotkim stressornym vozdeistviiam na ustoichivost' tkanei parodonta k ostromu stressu.

The experiments on 53 albino Wistar rats exposed to acute stress have demonstrated that there is activation of acid proteinases at pH 5.0 and an increase in the levels of sialic acids in parodontal tissue, which is an important mechanism in the development of their destructive changes. Preadaptation to short-term stresses produces a stress-protective effect, promoting the inhibition of proteolysis and the normalization of parodontal levels of sialic acids.

[Biochemical changes in mouth fluid in people with acute emotional stress exposed to natural and increased radiation]. / Izmenenie biokhimicheskikh pokazatelei, kharakternykh dlia ostrogo émotsionalnogo stressa, v rotovoi zhidkosti u liudei v usloviiakh estestvennogo i povyshennogo fonov radioaktivnosti.

Acute emotional stress in people is followed by changes in oral fluid composition (sialic acid, components of proteolytic system, lipid of peroxidation products). The possibility to use these indices for estimation of the psychoemotional stress in people is based.

[Characteristic of gastric response to acute and chronic stress and to their combination]. / Osobennosti reaktsii zheludka na ostryi i khronicheskii stressy, a takzhe na ikh sochetanie.

Experiments on 39 rats subjected to the effect of acute, chronic stresses and to that of their combination have revealed a parallelism between the degree of the ulcerogenic effect and depression of antioxidant activity of the stomach tissue cells.