Primary contact physiotherapy for patients with suggested vestibulopathy for an Australian ENT clinic: a retrospective cohort study.

OBJECTIVE: To examine the newly established role of a primary contact physiotherapist in an ENT clinic, in an Australian cohort and context, over two phases of development. METHODS: A retrospective cohort study was conducted with data collected from a medical record audit. Over the study duration, the primary contact physiotherapist completed initial appointments with patients; follow-up appointments were subsequently conducted by medical staff. RESULTS: There was a 46 per cent reduction in patients with suggested vestibulopathy requiring an ENT medical review. This reduction could hypothetically increase to 71 per cent with follow-up primary contact physiotherapist appointments. Improvements in the service delivery model and a primary contact physiotherapist arranging diagnostic assessments could improve waitlist times and facilitate better utilisation of medical staff time. CONCLUSION: The primary contact physiotherapist can help in the management of patients with suspected vestibulopathy on an ENT waitlist. This is achieved through: a reduction of patients requiring ENT review, improvements to waitlist time and improved utilisation of medical specialists' time.

Occupational therapist use of the 'Timed Up and Go' test in a Memory Clinic to compare performance between cognitive diagnoses and screen for falls risk.

INTRODUCTION: Occupational therapists assess older patients attending Memory Clinics to address multiple facets, including memory, activities of daily living function, mobility and falls risk. Identifying deficits in motor and functional abilities represents a crucial and necessary component of cognitive diagnosis. The aim of this research was to compare performance on the TUG between patients with normal (NC), mild cognitive impairment (MCI) and dementia. METHODS: A prospective single-blind single-centre cohort study was conducted in a Memory Clinic. Patients underwent comprehensive medical assessment, including the Mini Mental Status Examination (MMSE) to determine a cognitive diagnosis. The occupational therapist, blinded to any diagnosis, completed the TUG. RESULTS: A total of 158 patients aged 60 years and older were recruited. The average TUG was 15.4 s, which was similar between men and women (p = .87). A TUG greater than ≥14 s was significantly associated with the use of a walking aid (p ≤ .001). The TUG increased with age and a slower TUG was associated with a greater number of previous falls (p = .023). The TUG did not significantly differ between patients with dementia, MCI and NC (p = .095). However, there was a significant difference comparing patients with NC and MCI (14.3 s) to those with dementia (16.4 s) (p = .048). There was a significant weak negative correlation between the MMSE and the TUG of -0.253 (p = .003). Univariate models showed that a patient's ability to ambulate independently contributed to 33% of the variance in the TUG, whereas previous falls contributed to 4%, highlighting the importance of physical function and intervention to target this. CONCLUSION: A simple TUG test should be considered for use by occupational therapists in a Memory Clinic to screen patients at risk of falling. Patients diagnosed with dementia have a significantly slower TUG. However, this tool cannot assist with the early detection of patients with MCI.

Failure of falls risk screening tools to predict outcome: a prospective cohort study.

OBJECTIVE: To compare the Falls Risk for Older Persons-Community Setting Screening Tool (FROP Com Screen) with the Two-Item Screening Tool in older adults presenting to the ED. METHODS: A prospective cohort study, comparing the efficacy of the two falls risk assessment tools by applying them simultaneously in a sample of hospital ED presentations. RESULTS: Two hundred and one patients over 65 years old were recruited. Thirty-six per cent reported falls in the 6-month follow-up period. The area under the receiver operating characteristic curve was 0.57 (95% CI 0.48 to 0.66) for the FROP Com Screen and 0.54 (95% CI 0.45 to 0.63) for the Two-Item Screening Tool. FROP Com Screen had a sensitivity of 39% (95% CI 0.27 to 0.51) and a specificity of 70% (95% CI 0.61 to 0.78), while the Two-Item Screening Tool had a sensitivity of 48% (95% CI 0.36 to 0.60) and a specificity of 57% (95% CI 0.47 to 0.66). CONCLUSION: Both tools have limited predictive ability in the ED setting.

Controlled clinical trial exploring the impact of a brief intervention for prevention of falls in an emergency department.

OBJECTIVE: To establish the effectiveness of a brief intervention to prevent falls in older patients presenting to the ED post-discharge. METHODS: The present study is a prospective single-centre, quasi-randomised controlled clinical trial of a brief targeted educational intervention to prevent falls. The intervention group received brief scripted education and were advised of their percentage probability of falling in the next 6 months. The key message was to reinforce the importance of falls prevention strategies and the seriousness of falls. RESULTS: A total of 412 over 65 years old were recruited; 63 (32.1%) patients in the intervention group and 67 (36.8%) in the control group reported falls in the 6 month follow up period (OR 0.81, 95% confidence interval [CI] 0.53-1.25, P = 0.34). No significant differences were noted for mortalities (P = 0.54), ED representations (P = 0.15) and medication changes (P = 0.17). Patients receiving intervention had less hospital admissions (P = 0.002) after adjustment for confounding variables. Intervention patients who presented with a fall had significant (P = 0.007) improvement in function at 6 months, whereas those not presenting with a fall experienced functional decline. CONCLUSION: A brief intervention was associated with maintenance of function in fallers and reduced hospital admissions, without preventing falls post-discharge.

Effects of the association of diabetes and pulmonary emphysema on cardiac structure and function in rats.

Chronic obstructive pulmonary disease is often associated with chronic comorbid conditions of cardiovascular disease, diabetes mellitus and hypertension. This study aimed to investigate the effects of the association of diabetes and pulmonary emphysema on cardiac structure and function in rats. Wistar rats were divided into control non-diabetic instilled with saline (CS) or elastase (CE), diabetic instilled with saline (DS) or elastase (DE), DE treated with insulin (DEI) groups and echocardiographic measurements, morphometric analyses of the heart and lungs, and survival analysis conducted 50 days after instillation. Diabetes mellitus was induced [alloxan, 42 mg/kg, intravenously (iv)] 10 days before the induction of emphysema (elastase, 0.25 IU/100 g). Rats were treated with NPH insulin (4 IU before elastase plus 2 IU/day, 50 days). Both CE and DE exhibited similar increases in mean alveolar diameter, which are positively correlated with increases in right ventricular (RV) wall thickness (P = 0.0022), cavity area (P = 0.0001) and cardiomyocyte thickness (P = 0.0001). Diabetic saline group demonstrated a reduction in left ventricular (LV) wall, interventricular (IV) septum, cardiomyocyte thickness and an increase in cavity area, associated with a reduction in LV fractional shortening (P < 0.05), and an increase in LViv relaxation time (P < 0.05). Survival rate decreased from 80% in DS group to 40% in DE group. In conclusion, alloxan diabetes did not affect RV hypertrophy secondary to chronic emphysema, even in the presence of insulin. Diabetes per se induced left ventricular dysfunction, which was less evident in the presence of RV hypertrophy. Survival rate was substantially reduced as a consequence, at least in part, of the coexistence of RV hypertrophy and diabetic cardiomyopathy.

Estudo das alterações morfofuncionais cardíacas secundárias ao enfisema pulmonar induzido por elastase pancreática de porco em ratos diabéticos / Study of morphofunctional cardiac changes secondary to pulmonary emphysema induced by porcine pancreatic elastase in Diabetic Rats

Introdução: A Doença Pulmonar Obstrutiva Crônica (DPOC) está freqüentemente associada a comorbidades crônicas como a doença cardiovascular, o diabetes mellitus e a hipertensão. O presente estudo tem por objetivo investigar as alterações morfológicas e funcionais no coração secundárias ao enfisema pulmonar em ratos diabéticos. Métodos: Ratos Wistar machos adultos (200 ± 20 g, n = 36) foram destinados à avaliação ecocardiográfica, análise morfométrica do coração e pulmões e análise da taxa de sobrevida. O diabetes mellitus foi induzido por aloxana (42 mg/kg, iv) 10 dias antes da indução do enfisema pulmonar por instilação de elastase (0,25 UI/100 g de peso corpóreo). Um grupo de ratos diabéticos recebeu tratamento com insulina NPH (4 UI antes da elastase, seguido de 2 UI/dia, 50 dias). Os experimentos foram realizados 50 dias após a instilação. Resultados: Ratos diabéticos e respectivos controles instilados com elastase apresentaram aumentos similares no diâmetro médio alveolar, cujos valores correlacionam-se positivamente com aumentos na espessura da parede (p=0,0022), na área da cavidade (p=0,0001) e espessura dos cardiomiócitos (p=0,0001) do ventriculo direito (VD). Ratos tornados diabéticos por injeção de aloxana exibiram redução na espessura da parede do ventrículo esquerdo (VE), no septo interventricular (IV) e na espessura dos cardiomiócitos. Estas variáveis morfométricas associaram-se à redução da fração de encurtamento do VE (p < 0,05) e a aumento no tempo de relaxamento isovolumétrico do VE (p < 0,05). A taxa de sobrevida reduziu-se de 80% em ratos diabéticos a 40% em ratos diabéticos instilados com elastase (p < 0,05). Conclusões: O diabetes por aloxana em ratos não modifica a hipertrofia do VD secundária ao enfisema pulmonar, porém induz disfunção ventricular esquerda. A manifestação de ambas as doenças, diabetes mellitus e enfisema pulmonar, reduz substancialmente a taxa de sobrevida, enfatizando a condição de comorbidade na coexistência de...

Background: Chronic Obstructive Pulmonary Disease (COPD) is often associated with chronic comorbid conditions of cardiovascular disease, diabetes mellitus and hypertension. This study aimed to investigate morphological and functional alterations of the heart secondary to chronic emphysema in diabetic rats. Methods: Adult male Wistar rats (200 ± 20 g, n=36) were used for echocardiographic measurements, morphometric analyses of the heart and lungs, and survival rate. Diabetes mellitus was induced by alloxan (42 mg/kg, iv) 10 days before the induction of pulmonary emphysema by the instillation of elastase (0.25 IU/100 g body weight). A group of diabetic rats was treated with NPH insulin (4 IU before elastase, plus 2 IU/day, 50 days). Experiments were performed 50 days after instillation. Results: Both elastase-instilled diabetic rats and matching controls exhibited similar increases in mean alveolar diameter, which are positively correlated with increases in RV wall thickness (p=0.0022), cavity area (p=0.0001), and cardiomyocyte thickness (p=0.0001). Alloxan-diabetic rats demonstrated a reduction in left ventricular (LV) wall, IV septum, and cardiomyocyte thickness, associated with a reduction in LV fractional shortening (p<0.05), and an increase in LViv relaxation time (p < 0.05). Survival rate decreased from 80% in diabetic rats to 40% in elastase-instilled diabetic rats. Conclusions: Alloxan diabetes did not affect RV hypertrophy secondary to chronic emphysema, but induced LV dysfunction. The association of diabetes and emphysema substantially reduced the survival rate, emphasizing the comorbid condition of the coexistence of diabetes and COPD.

Effects of emergency department Care Coordination Team referrals in older people presenting with a fall.

OBJECTIVES: The study aims to describe the characteristics of patients presenting to an ED with a fall and evaluate multidisciplinary Care Coordination Team (CCT) referrals on patient outcomes. METHODS: A single-centred retrospective analysis of electronic data at an adult tertiary hospital was performed using data from 2004 to 2009 of presentations for patients aged 65 years or over with a fall. The primary outcome measure was representation to hospital within 30 days, comparing patients referred to CCT and those not referred. Secondary outcomes were differences in demographic characteristics, mode of arrival, triage score and readmission. RESULTS: The proportion of ED patients presenting with a fall and their mean age is stable over time. From 2006 to 2009, 5162 fallers were referred to CCT in a decreasing trend, but with increased urgency. Statistically significant predictors for being referred to CCT were increasing age, being female, arriving by ambulance, being transferred from a nursing home and higher socioeconomic category. Arrival by ambulance and a history of previous falls were associated with representation and readmission. A decreasing trend from 2006 to 2009 was seen in rate ratios and odds ratios via regression modelling for both representation and readmission in patients referred to CCT. CONCLUSION: Maturing of the CCT is associated with a decrease in representation and readmission rate. Over time, the CCT attended higher urgency patients associated with stable admission rates. These associations were not significant and the clinical effectiveness of ED CCTs requires further examination.

Insulin modulates inflammatory and repair responses to elastase-induced emphysema in diabetic rats.

As pulmonary emphysema and diabetes mellitus are common diseases, concomitance of both is correspondingly expected to occur frequently. To examine whether insulin influences the development of inflammation in the alveolar septa, diabetic male Wistar rats (alloxan, 42 mg/kg, i.v., n = 37) and matching controls (n = 31) were used. Ten days after alloxan injection, diabetic and control rats were instilled with physiologic saline solution containing porcine pancreatic elastase (PPE, 0.25 IU/0.2 ml, right lung) or saline only (left lung). The following analyses were performed: (i) number of leucocytes in the bronchoalveolar lavage (BAL) fluid of the animals, 6 h after PPE/saline instillation (early time point); and (ii) mean alveolar diameter (µm) and quantification of elastic and collagen fibres (%) 50 days after PPE/saline instillation (late time point). Relative to controls, alloxan-induced diabetic rats showed a 42% reduction in the number of neutrophils in BAL fluid, a 20% increase in the mean alveolar diameter and a 33% decrease in elastic fibre density in the alveolar septa. Treatment of diabetic rats with 4 IU neutral protamine Hagedorn (NPH) insulin, 2 h before elastase instillation, restored the number of neutrophils in the BAL fluid. The mean alveolar diameter and elastic fibre content in alveolar septa matched the values observed in control rats if diabetic rats were treated with 4 IU NPH insulin 2 h before instillation followed by 2 IU/day for the next 50 days. Density of collagen fibres did not differ between the various groups. Thus, the data presented suggest that insulin modulates the inflammatory and repair responses in elastase-induced emphysema, and assures normal repair and tissue remodelling.

Papel do hormônio insulina na modulação dos fenômenos inflamatórios / Role of insulin hormone in modulation of inflammatory phenomena

Evidence demonstrates the involvement of hormones in the development of inflammatory response. Inflammation evokes marked structural alterations of microvasculature, besides migration of leukocytes from microcirculation to the site of lesion. These alterations are caused primarily by release or activation of endogenous mediators, in which hormones play an integral role in this regulatory system. Binding sites for many hormones may be characterized by vascular structures and hematogenous cells involved with the inflammatory response. Quantitative alterations of inflammatory events involving the decrease in microvascular response to inflammatory mediators, deficiency in the leukocyte-endothelium interaction, reduction of cell concentration in the inflammatory exudate, and failure of the phagocyte function of mononuclear cells were observed in insulin-deficient states. Therefore, inflammation is not merely a local response, but rather a process controlled by hormones in which insulin plays an essential role in modulation of these phenomena, and assures tissue repair and emodeling within the limits of normality.

Evidências demonstram o envolvimento dos hormônios no desenvolvimento da resposta inflamatória. A inflamação evoca alterações estruturais marcantes da microvasculatura, além da migração dos leucócitos da microcirculação para o foco da lesão. Essas alterações são ocasionadas principalmente pela liberação ou ativação de mediadores endógenos, na qual os hormônios participam integralmente desse sistema regulador. Sítios de ligação para muitos hormônios podem ser caracterizados em estruturas vasculares e células hematógenas envolvidas com a resposta inflamatória. Alterações quantitativas dos eventos inflamatórios envolvendo a diminuição da resposta microvascular aos mediadores inflamatórios, deficiência entre a interação leucócito-endotélio, redução da concentração celular no exudato inflamatório e falha na função fagocitária dos mononucleares foram observadas em estados insulino-deficientes. Portanto, a inflamação não é meramente uma resposta local, mas um processo controlado por hormônios, no qual a insulina desempenha um papel essencial modulando esses fenômenos, e assegurando uma reparação e um remodelamento tecidual dentro dos limites da normalidade.

Role of insulin hormone in modulation of inflammatory phenomena.

Evidence demonstrates the involvement of hormones in the development of inflammatory response. Inflammation evokes marked structural alterations of microvasculature, besides migration of leukocytes from microcirculation to the site of lesion. These alterations are caused primarily by release or activation of endogenous mediators, in which hormones play an integral role in this regulatory system. Binding sites for many hormones may be characterized by vascular structures and hematogenous cells involved with the inflammatory response. Quantitative alterations of inflammatory events involving the decrease in microvascular response to inflammatory mediators, deficiency in the leukocyte-endothelium interaction, reduction of cell concentration in the inflammatory exudate, and failure of the phagocyte function of mononuclear cells were observed in insulin- deficient states. Therefore, inflammation is not merely a local response, but rather a process controlled by hormones in which insulin plays an essential role in modulation of these phenomena, and assures tissue repair and remodeling within the limits of normality.

Pathogenesis of pulmonary emphysema: cellular and molecular events / Patogenia do enfisema pulmonar: eventos celulares e moleculares

Pulmonary emphysema is a chronic obstructive disease, resulting from important alterations in the whole distal structure of terminal bronchioles, either by enlargement of air spaces or by destruction of the alveolar wall, leading to loss of respiratory surface, decreased elastic recoil and lung hyperinflation. For many years, the hypothesis of protease-antiprotease unbalance prevailed as the central theme in the pathogenesis of pulmonary emphysema. According to this hypothesis, the release of active proteolytic enzymes, produced mainly by neutrophils and macrophages, degrades the extracellular matrix, affecting the integrity of its components, especially collagen and elastic fibers. However, new concepts involving cellular and molecular events were proposed, including oxidative stress, cell apoptosis, cellular senescence and failed lung tissue repair. The aim of this review paper was to evaluate the cellular and molecular mechanisms seen in the pathogenesis of pulmonary emphysema.

O enfisema pulmonar é uma doença obstrutiva crônica, resultante de importantes alterações de toda a estrutura distal do bronquíolo terminal, seja por dilatação dos espaços aéreos, seja por destruição da parede alveolar, ocasionando a perda da superfície respiratória, diminuição do recolhimento elástico e hiperinsuflação pulmonar. Por muitos anos, a hipótese do desequilíbrio enzimático proteinase-antiproteinase prevaleceu como tema central na patogenia do enfisema. De acordo com essa hipótese, a liberação de enzimas proteolíticas ativas, produzidas principalmente por macrófagos e neutrófilos, degrada a matriz extracelular, afetando a integridade de seus componentes, particularmente as fibras colágeno e elástica. Entretanto, novos conceitos envolvendo eventos celulares e moleculares foram propostos, incluindo o estresse oxidativo, a apoptose celular, a senescência celular e a falha no processo de reparo do tecido pulmonar. O objetivo deste artigo de revisão foi avaliar os mecanismos celulares e moleculares da patogenia do enfisema pulmonar.

Pathogenesis of pulmonary emphysema - cellular and molecular events.

Pulmonary emphysema is a chronic obstructive disease, resulting from important alterations in the whole distal structure of terminal bronchioles, either by enlargement of air spaces or by destruction of the alveolar wall, leading to loss of respiratory surface, decreased elastic recoil and lung hyperinflation. For many years, the hypothesis of protease-antiprotease unbalance prevailed as the central theme in the pathogenesis of pulmonary emphysema. According to this hypothesis, the release of active proteolytic enzymes, produced mainly by neutrophils and macrophages, degrades the extracellular matrix, affecting the integrity of its components, especially collagen and elastic fibers. However, new concepts involving cellular and molecular events were proposed, including oxidative stress, cell apoptosis, cellular senescence and failed lung tissue repair. The aim of this review paper was to evaluate the cellular and molecular mechanisms seen in the pathogenesis of pulmonary emphysema.

Ventilatory and cardiovascular responses to unsupported low-intensity upper limb exercise in normal subjects.

The ventilatory and cardiovascular responses, and the rating of perceived exertion (RPE) to three types of unsupported low-intensity upper limb exercise (static, dynamic - unilateral and bilateral) were investigated in 22 normal subjects. A significant increase in tidal volume, respiratory rate, minute ventilation, oxygen consumption, carbon dioxide production and pulse rate occurred during all three exercises (p < 0.05). With the exception of tidal volume, these increases were significantly greater with dynamic exercise (p < 0.05). Local RPE was significantly higher than general RPE following both static and dynamic exercise (p < 0.05) with no significant differences between the three exercises. These findings provide some basis for the development of exercise protocols for testing in post-operative patients.