1.
Int J Pept Protein Res
; 23(5): 506-15, 1984 May.
Article
in English
| MEDLINE
| ID: mdl-6735590
ABSTRACT
A genetic variant of bovine proinsulin has been isolated using preparative reverse-phase HPLC. The new proinsulin (bovine proinsulin II) differs from the known proinsulin (bovine proinsulin I) by a single amino acid residue at position C-48 in the connecting peptide. The amino acid replacement is a leucine substitution for proline. The two proinsulins were found in a ratio of approximately 9:1, proinsulin I: proinsulin II. No chemical or biological differences were observed for the two proinsulins other than their different elution times on reverse-phase HPLC.
Subject(s)
Genetic Variation , Proinsulin/isolation & purification , Amino Acid Sequence , Animals , C-Peptide/genetics , Cattle , Chromatography, High Pressure Liquid , Humans , Proinsulin/genetics , Species Specificity , Swine
2.
J Am Chem Soc
; 93(13): 3302-3, 1971 Jun 30.
Article
in English
| MEDLINE
| ID: mdl-5559601