ABSTRACT
Nitric oxide is a biologic messenger molecule involved in a diverse range of physiologic processes. An exon 22 inducible nitric oxide synthase genotype has recently been reported to be protective against Parkinson disease in a European cohort. The authors confirm the protective effect of this genotype (OR = 0.5, 95% CI 0.27 to 0.93) in an independent Finnish case-control series.
Subject(s)
Nitric Oxide Synthase/physiology , Nitric Oxide/physiology , Parkinson Disease/enzymology , Adult , Aged , Aged, 80 and over , Alleles , Case-Control Studies , Exons/genetics , Female , Finland/epidemiology , Genetic Predisposition to Disease , Genotype , Haplotypes , Humans , Linkage Disequilibrium , Male , Middle Aged , Nitric Oxide Synthase Type II , Parkinson Disease/epidemiologySubject(s)
Gene Dosage , Mutation , Nerve Tissue Proteins/genetics , Parkinson Disease/genetics , Alleles , Exons , Family , Female , Genetic Linkage , Haplotypes , Humans , In Situ Hybridization, Fluorescence , Male , Pedigree , Polymorphism, Single Nucleotide , Promoter Regions, Genetic , Reverse Transcriptase Polymerase Chain Reaction , Synucleins , alpha-SynucleinABSTRACT
Mutations in DJ-1 are a cause of autosomal recessive parkinsonism. Polymorphism of genes implicated in hereditary forms of parkinsonism may be a predisposing factor in sporadic Parkinson's disease (PD). The authors analyzed whether a polymorphism (g.168_185del) within exon 1 of DJ-1 contributes to the risk of sporadic PD in a Finnish case-control series. This gene does not play a major role in the genetic predisposition to PD in this population.
