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Bull Exp Biol Med ; 174(4): 435-439, 2023 Feb.
Article in English | MEDLINE | ID: mdl-36892672

ABSTRACT

Analysis of the pharmacological activity of the original drug Prospekta in a rat model of focal cerebral ischemia revealed its nootropic effect: course treatment in the post-ischemic period led to recovery of the neurological status of animals at the peak of neurological deficit. Evaluation of the therapeutic potential of the drug in morphological and functional CNS disorders allowed us to conclude that it is advisable to carry out further studies of its biological activity at the preclinical stage (the results obtained in animals were successfully confirmed in a clinical trial of drug efficacy in the treatment of moderate cognitive disorders in the early recovery period after ischemic stroke). Studies of the nootropic activity in other pathologies of the nervous system are also promising.


Subject(s)
Brain Ischemia , Ischemic Stroke , Nootropic Agents , Stroke , Animals , Rats , Brain Ischemia/drug therapy , Cerebral Infarction/drug therapy , Stroke/drug therapy
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