ABSTRACT
Objetivos: La utilización del «agua de 3 sulfatos» (sulfato de cinc, cobre y alumínico-potásico) se cita en la literatura como un posible tratamiento para la balanitis y balanopostitis; ahora bien, no existen trabajos prospectivos que documenten su eficacia clínica. Pretendemos estudiar dicha eficacia. Material y método: Presentamos un estudio aleatorizado doble ciego sobre 50 pacientes con balanitis o balanopostitis en el que se comparan los resultados clínicos del «agua de 3 sulfatos» (30 pacientes) frente a una solución salina (20 pacientes). Los parámetros clínicos estudiados han sido: exudado, eritema, edema, escozor y prurito. Resultados: Una vez aplicados los test estadísticos, hemos observado que el «agua de 3 sulfatos» ha sido superior al suero salino en todos los parámetros clínicos estudiados, aunque las diferencias solo han sido significativas para el parámetro exudado. Conclusiones: El «agua de 3 sulfatos» se ha mostrado significativamente más eficaz que el suero fisiológico en la eliminación del exudado de las balanitis y balanopostitis agudas de nuestro estudio. La tolerabilidad de los tratamientos ha sido excelente
Objectives: Despite scientific literature mentions the application of 'water of the 3 sulfates' (copper sulphate, zinc sulphate and alum) as a treatment for acute balanitis and balanoposthitis, no clinical trials evaluating its efficacy have been found. In our study we evaluate the efficacy of this solution in acute balanitis and balanoposthitis. Material and methods: A double-blind randomized study was designed to compare the efficacy of 'water of the 3 sulfates' (intervention) with saline solution (control) in 50 patients (30 patients and 20 patients, respectively) who suffer from acute balanitis or balanoposthitis. Exudate, erythema, oedema, burning, and itching were the clinical parameters assessed. Results: for all clinical parameters assessed, the outcomes obtained with 'water of the 3 sulfates' are higher than control, although significant differences only have been found for exudate. Conclusions: in our study, the 'water of the 3 sulfates' is significantly more effective than saline solution for removing exudates in acute balanitis and balanoposthitis. Tolerability was excellent in both treatments
Subject(s)
Humans , Male , Female , Middle Aged , Balanitis/drug therapy , Alum Compounds/therapeutic use , Copper Sulfate/therapeutic use , Zinc Sulfate/therapeutic use , Administration, Topical , Double-Blind Method , Therapeutic IrrigationABSTRACT
OBJECTIVES: Despite scientific literature mentions the application of "water of the 3 sulfates" (copper sulphate, zinc sulphate and alum) as a treatment for acute balanitis and balanoposthitis, no clinical trials evaluating its efficacy have been found. In our study we evaluate the efficacy of this solution in acute balanitis and balanoposthitis. MATERIAL AND METHODS: A double-blind randomized study was designed to compare the efficacy of "water of the 3 sulfates" (intervention) with saline solution (control) in 50 patients (30 patients and 20 patients, respectively) who suffer from acute balanitis or balanoposthitis. Exudate, erythema, oedema, burning, and itching were the clinical parameters assessed. RESULTS: for all clinical parameters assessed, the outcomes obtained with "water of the 3 sulfates" are higher than control, although significant differences only have been found for exudate. CONCLUSIONS: in our study, the "water of the 3 sulfates" is significantly more effective than saline solution for removing exudates in acute balanitis and balanoposthitis. Tolerability was excellent in both treatments.
Subject(s)
Alum Compounds/therapeutic use , Balanitis/drug therapy , Copper Sulfate/therapeutic use , Zinc Sulfate/therapeutic use , Administration, Topical , Aged , Double-Blind Method , Exudates and Transudates , Foreskin , Humans , Male , Middle Aged , Sodium Chloride , Solutions/therapeutic use , Therapeutic IrrigationABSTRACT
The retention and separation of a series of D,L dansyl amino acids (used as test solutes) on a teicoplanin stationary phase were investigated over a wide range of mobile phase (citrate buffer-methanol, 90:10, v/v) pH. An approach based on the development of various equilibria was carried out in order to describe the retention behavior of the solute in the chromatographic system. The equilibrium constants corresponding to the transfer of the anionic and zwitterionic forms of the dansyl amino acids from the mobile to the stationary phase were determined. These values allowed one to explain the decrease in the retention factor and the associated increase in the separation factor as the eluent pH was increased. Thermodynamic parameter variations were calculated so that the driving forces of the solute association with the teicoplanin phase were derived. This approach indicated that the chiral discrimination was principally controlled by the interaction between the anionic form of the solute and the stationary phase.
Subject(s)
Amino Acids/isolation & purification , Chromatography, High Pressure Liquid/methods , Dansyl Compounds/isolation & purification , Teicoplanin , Amino Acids/chemistry , Chromatography, High Pressure Liquid/instrumentation , Dansyl Compounds/chemistry , Electrochemistry , Hydrogen-Ion Concentration , Indicators and Reagents , Ions , Stereoisomerism , ThermodynamicsABSTRACT
Parameatal cysts of the penis are highly infrequent, benign cysts of varied sizes usually unilateral. Contribution of two cases of parameatal cysts of the penis, one and epidermoid inclusion, allegedly post hypospadias surgery, while the other one is similar to the middle raphe cysts and appears to derive from the endodermal debris following a defective closure of the urogenital folds. Treatment is by surgical excision; simple aspiration or marsupialization may result in relapse and unsatisfactory cosmetic results.
