ABSTRACT
A nine-year-old dog presented with clinical signs consistent with bilateral trigeminal neuropathy. Multicentric lymphoma was diagnosed, and neoplastic lymphocytes were identified in the cerebrospinal fluid. Electromyography revealed spontaneous activity in temporal and masseter muscles. Histopathological examination demonstrated neoplastic cell invasion of temporal and masseter myofibers and of multiple peripheral nerves, including the trigeminal nerve. Central nervous system pathology consisted primarily of spinal root and leptomeningeal lymphoid cell infiltration with relative sparing of spinal cord and brain parenchyma.
Subject(s)
Dog Diseases/diagnosis , Lymphoma, Non-Hodgkin/veterinary , Nervous System Neoplasms/veterinary , Trigeminal Nerve Diseases/veterinary , Animals , Dog Diseases/cerebrospinal fluid , Dogs , Electromyography/veterinary , Fatal Outcome , Female , Lymphoma, Non-Hodgkin/cerebrospinal fluid , Lymphoma, Non-Hodgkin/complications , Lymphoma, Non-Hodgkin/pathology , Masseter Muscle/pathology , Masseter Muscle/physiopathology , Nervous System Neoplasms/cerebrospinal fluid , Nervous System Neoplasms/complications , Nervous System Neoplasms/pathology , Temporal Muscle/pathology , Temporal Muscle/physiopathology , Trigeminal Nerve Diseases/etiologyABSTRACT
OBJECTIVE: To evaluate the feasibility of using a subconjunctivally implanted micro-osmotic pump for continuous delivery of medication to the eyes of horses- during a 7-day period. ANIMALS: 4 healthy adult horses. PROCEDURE: With horses restrained in a standing position, micro-osmotic pumps were implanted subconjunctivally in each eye for 7 days. The treatment eye received an atropine-loaded micro-osmotic pump (100 microl of 1.5% atropine), and the contralateral eye received a sterile saline-loaded pump (100 microl of 0.9% NaCl) as a control treatment. Pupil size was measured at 12-hour intervals until values returned to baseline. RESULTS: The micro-osmotic pumps were tolerated and did not migrate or become dislodged. During the 7-day treatment period, pupils were significantly larger in the eyes implanted with atropine-loaded pumps, compared with saline-implanted control eyes. CONCLUSIONS AND CLINICAL RELEVANCE: Micro-osmotic pumps were implanted and removed easily from standing horses and were not associated with complications during the 7-day treatment period. Therefore, subconjunctivally implanted micro-osmotic pumps can potentially be used when treating ophthalmic disease in horses.
