1.
Bioorg Med Chem Lett
; 22(7): 2534-5, 2012 Apr 01.
Article
in English
| MEDLINE
| ID: mdl-22366656
ABSTRACT
A number of oroxylin A analogs were prepared and evaluated for their inhibitory activities against iNOS-mediated nitric oxide (NO) production from LPS-stimulated BV2 cells. The analogs were synthesized from purchased 2'-hydroxy-4,5,6-trimethoxyacetophenone and aldehydes in 3 steps. Among the tested compounds, several analogs (3b, 3c, 3d, 3f) exhibited strong inhibitory activities. Especially, the analog with 4-nitrophenyl group (3b) showed stronger inhibitory activity (IC(50)=4.73 µM) than that of wogonin (IC(50)=7.80 µM).