ABSTRACT
Sixteen compounds were isolated from the fresh roots of Piper sarmentosum. Seven of these have been previously isolated from the fruits and leaves of this plant: the aromatic alkene (1), 1-allyl-2-methoxy-4,5-methylenedioxybenzene (4), beta-sitosterol, pyrrole amide (6), sarmentine (10), sarmentosine (13) and pellitorine (14). (+)-Sesamin (2), horsfieldin (3), two pyrrolidine amides 11 and 12, guineensine (15) and brachystamide B (16) are new for P. sarmentosum. Sarmentamide A, B, and C (7-9) are new natural products. Compounds 1--4 and 6--16 were tested for antiplasmodial, antimycobacterial and antifungal activities.
Subject(s)
Anti-Infective Agents/chemistry , Piper/chemistry , Pyrrolidinones/chemistry , Animals , Anti-Infective Agents/isolation & purification , Anti-Infective Agents/pharmacology , Antifungal Agents/pharmacology , Antimalarials/pharmacology , Antitubercular Agents/pharmacology , Candida albicans/drug effects , Magnetic Resonance Spectroscopy , Microbial Sensitivity Tests , Molecular Conformation , Mycobacterium tuberculosis/drug effects , Plant Extracts/chemistry , Plant Extracts/pharmacology , Plant Roots/chemistry , Plasmodium falciparum/drug effects , Pyrrolidines , Pyrrolidinones/isolation & purification , Pyrrolidinones/pharmacology , Spectrophotometry, Infrared , Spectrophotometry, UltravioletABSTRACT
Four new chromones, perforamone A, B, C, and D have been isolated together with six known compounds, peucenin-7-methyl ether, O-methylalloptaeroxylin, perforatic acid, eugenin, saikochromone A and greveichromenol, from the branches of Harrisonia perforata (Simaroubaceae). The structures were identified by spectroscopic data. The compounds were tested for antimycobacterial and antiplasmodial activities.
Subject(s)
Chromones/chemistry , Chromones/pharmacology , Simaroubaceae/chemistry , Animals , Antimalarials/chemistry , Antimalarials/pharmacology , Antitubercular Agents/chemistry , Antitubercular Agents/pharmacology , Chromatography, Thin Layer , Chromones/isolation & purification , Magnetic Resonance Spectroscopy , Mycobacterium tuberculosis , Plasmodium falciparum/drug effects , Spectrophotometry, Infrared , Spectrophotometry, UltravioletABSTRACT
A mixture of nine cerebrosides and a monoacylmonogalactosylglycerol were separated from the leaves of Clinacanthus nutans. The structures of the cerebrosides were characterized as 1-O-beta-D-glucosides of phytosphingosines, which comprised a common long-chain base, (2S,3S,4R,8Z)-2-amino-8(Z)-octadecene-1,3,4-triol with nine 2-hydroxy fatty acids of varying chain lengths (C(16), C(18), C(20-26)) linked to the amino group. The glycosylglyceride was characterized as (2S)-1-O-linolenoyl-3-O-beta-D-galactopyranosylglycerol. The structures were established on the basis of the spectroscopic data and chemical reactions.
