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1.
Sediment toxicity of the Anacostia River estuary, Washington, DC.
Phelps, H L.
Bull Environ Contam Toxicol ; 51(4): 582-7, 1993 Oct.
Article in English | MEDLINE | ID: mdl-8400662

Subject(s)
Water Pollutants, Chemical/toxicity , Animals , Bivalvia/drug effects , District of Columbia , Fresh Water , Larva/drug effects
2.
Development of an estuarine sediment burrowing bioassay for shipboard use.
Phelps, H L.
Bull Environ Contam Toxicol ; 45(5): 722-8, 1990 Nov.
Article in English | MEDLINE | ID: mdl-2265272

Subject(s)
Bivalvia/analysis , Water Pollutants, Chemical/analysis , Animals , Seawater/analysis , Specimen Handling , United States , United States Environmental Protection Agency , Virginia
3.
Estuarine sediment bioassay with oyster pediveliger larvae (Crassostrea gigas).
Phelps, H L; Warner, K A.
Bull Environ Contam Toxicol ; 44(2): 197-204, 1990 Feb.
Article in English | MEDLINE | ID: mdl-2322659

Subject(s)
Ostreidae/physiology , Water Pollutants, Chemical/toxicity , Water Pollutants/toxicity , Animals , Copper/toxicity , Hydrogen-Ion Concentration , Larva , Lethal Dose 50 , Seawater/analysis , Temperature , Water Pollutants, Chemical/analysis
4.
Clam burrowing bioassay for estuarine sediment.
Phelps, H L.
Bull Environ Contam Toxicol ; 43(6): 838-45, 1989 Dec.
Article in English | MEDLINE | ID: mdl-2597787

Subject(s)
Bivalvia/physiology , Water Pollutants, Chemical/toxicity , Water Pollutants/toxicity , Animals , Behavior, Animal/physiology , Copper/toxicity
5.
Aflatoxin B1: binding to DNA in vitro and alteration of RNA metabolism in vivo.
Sporn, M B; Dingman, C W; Phelps, H L; Wogan, G N.
Science ; 151(3717): 1539-41, 1966 Mar 25.
Article in English | MEDLINE | ID: mdl-5909585

ABSTRACT

Aflatoxin B(1) binds to both native and denatured DNA, as shown by spectroscopy and equilibrium dialysis. It also strongly inhibits incorporation of cytidine into rat liver nuclear RNA and lowers the RNA content of the nucleus. The extremle toxicity and carcinogenicity of aflatoxin B(1) may be direct results of the affinity of this agent for DNA.


Subject(s)
Aspergillus , Carcinogens/pharmacology , DNA , Liver/cytology , RNA/biosynthesis , Toxins, Biological/pharmacology , Aflatoxins/pharmacology , Animals , In Vitro Techniques , Liver/enzymology , Liver/metabolism , Nucleosides/metabolism , Rats , Spectrophotometry , Transaminases/biosynthesis , Tritium , Tryptophan Oxygenase/biosynthesis
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