1.
Bioorg Med Chem Lett
; 8(21): 3101-6, 1998 Nov 03.
Article
in English
| MEDLINE
| ID: mdl-9873684
ABSTRACT
Using an intramolecular [2 + 2] photocyclization, 2,4-methanopyrrolidine-2,4-dicarboxylate was prepared as a conformationally locked analogue of glutamate. This compound, in combination with two other pyrrolidine dicarboxylates, has been used to define the structural elements that differentiate substrate and nonsubstrate inhibitors of a high-affinity, sodium-dependent glutamate transporter.