ABSTRACT
PURPOSE: We determined the effect of the number of core biopsies of the prostate on predicting the Gleason score of the prostatectomy specimen. MATERIALS AND METHODS: The Gleason scores from 124 radical prostatectomy specimens were compared to those from preoperative core needle biopsies of the prostate. The number of cores obtained and tumor stage were compared regarding agreement in prostate cancer score. RESULTS: Four to 6 core biopsies yielded the best results, with agreement within 1 Gleason score in 75% of the cases. Further increases in the number of core biopsies did not improve results. Additionally, 37% of the well differentiated tumors on core biopsy were stage C. CONCLUSIONS: Gleason score from the core biopsy has limitations in respect to predicting prostatectomy tumor score and stage and, therefore, it is problematic for use in therapeutic decision making.
Subject(s)
Biopsy, Needle/statistics & numerical data , Prostatic Neoplasms/pathology , Analysis of Variance , Humans , Logistic Models , Male , Neoplasm Staging , Postoperative Care , Predictive Value of Tests , Preoperative Care , Prostatectomy , Prostatic Neoplasms/surgery , Reproducibility of ResultsABSTRACT
A total of 390 body cavity fluids were analyzed by both cytopathologic examination and flow cytometric DNA analysis. The two methods gave compatible results in analyses of 304 fluids (78%). In 24 patients, cytopathologic studies found the specimens to contain malignant cells, but the DNA content was diploid. This illustrates an area where flow cytometric studies do not extend tumor detection. In 56 fluids from 48 patients, cytologic methods revealed no malignant cells but flow cytometry distinguished aneuploid cell populations; additional clinical information allowed the identification of malignant tumors in 24 (50%) of these patients. Because flow cytometry was able to detect aneuploidy in cases where conventional cytologic examination could not detect malignant cells, the number of patients with tumors detected was increased by 39% beyond those detected by cytologic methods alone in this series.
Subject(s)
Body Fluids/cytology , DNA, Neoplasm/analysis , Neoplasms/diagnosis , Aneuploidy , Body Fluids/analysis , Breast Neoplasms/diagnosis , Breast Neoplasms/genetics , Breast Neoplasms/pathology , Diagnosis, Differential , Female , Flow Cytometry , Humans , Lung Neoplasms/diagnosis , Lung Neoplasms/genetics , Lung Neoplasms/pathology , Neoplasms/genetics , Neoplasms/pathology , Ovarian Neoplasms/diagnosis , Ovarian Neoplasms/genetics , Ovarian Neoplasms/pathology , Ploidies , Prospective StudiesABSTRACT
Cerebral amyloid angiography can cause ischemic stroke and transient ischemic attacks (TIA's), as illustrated by this case report and literature review. It is possible that the use of anticoagulant or platelet-antiaggregant drugs in elderly patients with TIA's but no angiographic abnormalities may increase the risk of hemorrhage from unsuspected amyloid angiopathy.
Subject(s)
Amyloidosis/complications , Brain Diseases/complications , Ischemic Attack, Transient/etiology , Aged , Amyloidosis/diagnosis , Anticoagulants/adverse effects , Aspirin/adverse effects , Brain/blood supply , Brain Diseases/diagnosis , Humans , Ischemic Attack, Transient/diagnosis , MaleABSTRACT
A neoplasm of unknown origin in cervical and axillary lymph nodes was diagnosed as anemone cell tumor by ultrastructural examination. Three years after the initial diagnosis of anemone cell tumor, a high-grade transitional cell carcinoma of the bladder was discovered. The results of immunoperoxidase staining of the cervical lymph node, axillary lymph node, and bladder tumors for keratin, carcinoembryonic antigen, and human chorionic gonadotropin (HCG) strongly suggest that the anemone cell tumors in this case represent metastases of bladder carcinoma cells capable of producing HCG.
