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Complete NMR assignment and absolute configuration of feronielloside, a new acetylcholinesterase inhibitor from Feroniella lucida.
Phoopichayanun, Chalouyluk; Phuwapraisirisan, Preecha; Tip-Pyang, Santi; Jongaramruong, Jongkolnee.
Nat Prod Res ; 22(15): 1297-303, 2008.
Article in English | MEDLINE | ID: mdl-19023785

ABSTRACT

Feronielloside (1), a new furanocoumarin glycoside, was isolated from roots of Feroniella lucida. The structure of 1 was elucidated by combined spectroscopic and chemical analysis. The absolute configuration of the chiral center in geranyl-derived side chain was confirmed by modified Mosher's method. Feronielloside inhibited acetylcholinesterase with IC(50) value of 24.7 mM.


Subject(s)
Acetylcholinesterase/metabolism , Cholinesterase Inhibitors , Coumarins , Furans , Glycosides , Plants, Medicinal/chemistry , Rutaceae/chemistry , Cholinesterase Inhibitors/chemistry , Cholinesterase Inhibitors/isolation & purification , Cholinesterase Inhibitors/pharmacology , Coumarins/chemistry , Coumarins/isolation & purification , Coumarins/pharmacology , Furans/chemistry , Furans/isolation & purification , Furans/pharmacology , Glycosides/chemistry , Glycosides/isolation & purification , Glycosides/pharmacology , Molecular Structure , Nuclear Magnetic Resonance, Biomolecular , Plant Roots/chemistry , Thailand
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