[Multiple eccrine-pilar hamartoma]. / Hamartoma múltiple ecrino-pilar.

Two cases with acquired lesions on the face and tendency to spread are reported. The unusual lesions have the appearance between millium and atrophodermia vermiculate and the histology presents features of syringoma and trichoepithelioma making this hamartoma unclassifiable. Cases with similar characteristics are discussed.

In vitro studies of the metabolic pathway from 8-COOH porphyrins to 4-COOH porphyrins.

The authors report the experiments about incubation of uroporphyrinogen with sonified fibroblasts of normal individuals and prophyrics and present the hypothesis of the absence of deficiency in the activity of uroporphyrinogendecarboxylase.

[Desmoplastic melanoma]. / Melanoma desmoplástico.

Conley et al., in 1971, described a special type of melanoma characterized by a superficial melanic lesion at the onset; repeated local relapses as subcutaneous tumorations with an histological picture closely resembling an atypical fibroxantoma or fibrosarcoma. After a review of all the published material the autors presents a personal case with the clinical, histological and evolutive characteristics of this disease. The most interesting findings of the published case are the following: The special stains for the melanocytes (silver stain, Dopa, tyrosinase and cholinesterase) were all negative. There was an intense positivity for the lisosomal enzymes (non specific sterases, and acid phosphatases). The ultrastructural study of the tumoral tissues as well as the cells of cultures showed abundant cells with tumoral aspects, with prominent nucleoli somewhat dilated granular endoplasmic reticulum, myelin-like figures, lipidic vacuoles and abundant lisosomes. No melanosomes or premelanosomes were observed. Beside these tumoral cells abundant typical fibroblastic elements were found. There was a great amount of collagen fibers with periodicity superior to the normal. The conclusion is that the desmoplastic melanoma must be considered as a tumor of mesenchimatous origin intervening in its development multiple local and general factors.

[Focal epidermal necrolisis. A variation of lupus erythematosus of a new disease?]. / Necrolisis epidérmica focal una variedad de lupus eritematosos o una nueva enfermedad?

Four cases with clinical characteristics closely related to Lupus Erythematosus Disseminatum are reported by the authors. The evolution, progress and the biochemical, immunological and photobiological data were different from those usually found in L.E.D. The histopathological picture was also dissimilar, the most characteristic finding being a sharply limited epidermal necrolysis with focal distribution. In view of the peculiarities of the clinico-pathological syndrome presented by these patients, the authors raise the questions does it represent a special modality of L.E.D. or a new lupus-like disease?

Lymphomatoid papulosis. A model of immunoblastic reaction of the skin.

In 3 cases of lymphomatoid papulosis with few ulceronecrotic lesions and 5 with the classic features of pytiriasis lichenoides acuta with necrotic lesions, a considerable part of the cellular component of the infiltrate of the lesions showed the morphologic and cytochemical characteristics of the cells described as immunoblasts. The authors consider that the lymphomatoid papulosis could represent an immunoblastic response to an unknown antigen.

Necropsy and ultrastructural findings in histiocytic medullary reticulosis.

In a case of histiocytic medullary reticulosis with protracted course and necrotic skin lesions, histological study revealed infiltration of the fat tissue by atypical reticulohistiocytic cells, areas of associated fat necrosis and vascular lesions. Autophagocytosis (phagocytosis of erythrocytes, erythroblasts, platelets, lymphoid cells, and nuclear debris) was found in biopsy specimens of the subcutaneous infiltrates, lymph nodes, and bone marrow, and in necropsy specimens of skin, iliac mesenteric lymph nodes, bone marrow, liver, spleen, and suprarenal glands. Electron microscopy of various viscera showed abnormal histiocytic cells containing multiple phagocytosed erythrocytes and other blood cells in different stages of destruction and digestion. Multi-membranous bodies also were present. Defective lysosomal degradation of intracytoplasmatic ceroids in this condition is postulated.

[False basalnomas and false cutaneous metastasis of visceral cancer. Apropos of 7 observations of eccrine carcinoma]. / Falsos basaliomas y falsas metástasis cutáneas de carcinomas viscerales. A propósito de 7 observaciones de carnimoma ecrino

After a review of the bibliography on the subject of eccrine sweat gland carcinomas, the authors emphasize the confusing terminology used for the designation of these cases and the difficulties for a correct clinical and histological diagnosis of these tumors. According to the data obtained from the study of 7 personal cases, the most characteristic features of the eccrine carcinomas could be the following: 1) From the clinical standpoint--Appearance of a single tumour, lasting unmodified for a long period of time.--Tendency to reccurrence of the neighbouring areas after tumour excision, and to a slow progression through the superficial lymphatic channels.--Appearance of distant metastasis a long time after the original lesion. These metastases are observed, a) on the regional lymph nodes, b) on the superficial lymphatic channels and c) in some cases in the skin by intraepidermal growth. 2) From the histological point of view--Localisation in the deep dermis of the tumoral masses in the original lesion.--Acinar or tubular structures. Abundant nitoses and considerable indifferntiation of the cellular elements.--Tendency to the formation of empty peritumoral spaces separating the tumoral masses from the connective tissue by the retraction caused by the fixative.--Styloid or trabecular growth surrounding the main mass of the tumor.--Two types of cells can be observed in some tumours; large cells with a clear cytoplasm and small deeply-stained cells resembling the mioepithelial cells.--Tendency to the formation of clear cell tumoral masses.--Squamous metaplasia of isolated cells or groups of cells.--Presence of PAS-positive cytoplasmatic granulations in some cellular elements.--Degenerative changes with secondary cystic formations.--Frequent features of tumoral lymphangitis. 3y From theions.--Frequent features of tumoral lymphangitis. 3) From the cytological standpoint Staining in yellow of the cytoplasms of the tumour cells with the Panpanicolau method. 4) From the ultrastructural standpoint--Impossibility of classifiying the cells into serous or mucous due to the considerable anaplasia.--Absence of eccrine-apocrine differentiation, of ductal formation and of embrionary sweat cell features.

[Contact dermatitis caused by plastic pockets on trouser]. / Dermatitis de contacto por bolsillos de plástico de pantalones

An hitherto undescribed type of contact dermatitis in a series of 16 patients is described by the authors. The lesions were localized in the anterior and anterolateral aspects of the thighs and were sharply limited in the area contacting the trouser pockets, manufactured with synthetic fabrics. In 17 patients of this series there was a concomitant dermatitis in the exposed areas of the face and hands. The authors described the processing in the manufacture of these pockets, the end step being the obtention of poliamide, through different precursor substances. The poliamide is treated with different aditives giving rise to the nylon fiber, which is used to manufacture the definitive tissue. A list of adequate allergens and their concentrations used in the 16 patients is given in the paper. The results of the patch tests and the fact that all the clinical symptoms of the patients disappeared after the withdrawal of the tissue pockets and substitution by cotton tissue give a reasonable basis to the hypothesis of contact dermatitis caused by this tissue. However, the true specific allergen is not demonstrated yet.

[Pseudoxanthomatous mastocytosis with aspects of nervus elasticus]. / Mastocitósis pseudoxantomatosa con aspecto de nevus elástico

A case of mastocytosis is presented by the authors. The lesions appeared in early childhood with the typical appearance of urticaria pigmentosa. With the course of the years they changed becoming micropapular and assuming the appearance of the clinical picture described by Griffiths and Daneshbod as pseudoxantomatosis mastocytosis, although some clinical and histological aspects resembled the morphology and structure of the "nevus elasticus".

[Epithelioise sarcoma. A myofibroblastoma tumor]. / Sarcoma epitelioide. Un tumor de miofibroblastos

A case of epithelioid sarcoma in a 48 year old man is described by the authors. The ultrastructural study showed the presence of abundant cellular elements showing some features closely similar to those of the so-called myofibroblasts. These were: folds in the nuclear membrane, abundant rough endoplasmic reticulum, thick bundles of microfilaments resembling those of the smooth muscle, junctional complexes and degenerative changes (lipid droplets and autophagic vacuoles). These findings suggest the possibility that the epithelioid sarcoma could be a neoplasia originating from the myofibroblasts.

[Summer lichenoid papulosis]. / Papulosis liquenoide estival

A possibly new clinical picture observed in summer time is described by the authors. It consists of a lichenoid eruption suggesting sand dermatitis and occurring after prolonged sun exposures. The symptoms disappear 6-8 days after exposure but recurred at each new sun bath. The localization of the lesions on both covered and uncovered parts of the body did not favour the hypothesis of a direct action on the skin of the sun radiation. The histological picture was characteristic and consisted of focal parakeratosis, spongiosis, exocytosis of the epidermis and an angeitis of the blood vessels, of the upper dermis with alteration of the walls and lymphohistiocytary infiltrate of importance disproportionate to the smallnes of the clinical lesion. The name of "summer lichenoid papulosis" is given by the authors to this clinical entity and the differential diagnosis with other similar clinical pictures is established.

[Disseminated plane xanthoma with photosensitization]. / Xantoma plano diseminado con fotosensibilidad

A case of diffuse normolipemic plane xanthome showing no association with systemic disease (multiple myeloma, leukemia, reticulosis, or dysglobulinaemia), in a 50 year old female, is reported. The patient presented hypersensitivity to the erythrogenic spectrum with pathological response and lowered MED. The B lymphocytes in the peripherical blood was raised. The authors postulated that B lymphocytes probably play an important role in the pathogenesis of the skin light-induced reactions.

[Ultrastructural and cytological study of atypical fibroxanthoma]. / Estudio citológico y ultraestructural del fibroxantoma atípico

A case of atypical fibroxanthoma of the skin is related. Ulstrastructural findings include: fibroblast-like cells, histiocytic-like cells, xanthomatous cells, and multinucleated cells. Strikingly similar findings were found by Fu and cols. (1975) in four cases of malignant fibrous histiocytoma. The authors postulated that both tumours could represent different aspects of a single proliferating process.

[Determination of B lymphocytes: immunofluorescence and peroxidase dyes (preliminary note)]. / Determinación de linfocitos B: inmunofluorescencia y tinción de peroxidasas. (Nota previa)

A determination of the lymphocyte levels in blood and cutaneous infiltrates of 60 patients complaining of different dermatoses were carried out by the authors. The method used in the experience was that of Preud'homme and Flandrin (1974). In most of the investigated cases the results could be considered as normal (8-22%). In one case of actinic reticuloid and 2 cases of plane xanthoma with photosensitivity the levels were considerably raised. The authors belleve that the B-lymphocytes determination could be worth investigation in the photosensitive dermatoses.

[Punctate porokeratotic keratodermia associated with hepatic cirrhosis]. / Queratodermia punctata poroqueratósica asociada a cirrosis hepática

A case of non familial Punctate Porokeratotic Keratoderma in a man with liver cirrhosis is reported. The relation between both syndroms as well as the possible nevoid origin of this type of porokeratose is discussed.

[Hepato-erythrocytic porphyria. A new type of porphyria]. / Porphyrie hépato-érythrocytaire. Une nouvelle forme de porphyrie

A case of porphyria with symptomatology beginning in early infancy with peculiar biochemical features is described. There were crops of blisters, an extraordinary hypertrichosis and scarring of the exposed skin. The porphyrin examination showed an abnormal excretion pattern of urinary porphyrins with large amounts of 5-COOH carboxyle porphyrins and the protoporphyrin level of the red cells was raised. There was fluorescence of the erythrocytes and erythroblasts. The porphyrin excretion pattern of the stools was similar to those of the PCT. This case is closely similar to another published by the authors in 1969 and to 2 published by Schneider and Simon. The authors consider that could represent a new type of porphyria.