ABSTRACT
Histopathological investigations were done in 72 cases of periapical granulomas and 9 cases of periapical cysts demonstrating that both granulomas and cysts were composed of granulation tissue varying in maturity. Immunohistochemical studies by the peroxidase method PAP showed the presence of light chains (kappa and lambda) and heavy chains (IgA, IgM, IgG, IgE). In the chronic inflammatory infiltrates of granulomas and cysts plasma cells with IgG prevailed. These observations suggest that specific immune reactions participate in the pathological mechanism of chronic periapical inflammatory processes.
Subject(s)
Periapical Granuloma/immunology , Radicular Cyst/immunology , Adolescent , Adult , Aged , Child , Humans , Immunoglobulin G/analysis , Immunohistochemistry , Middle AgedABSTRACT
Chronic periapical lesions were recognized clinically and radiologically in 109 patients aged from 10 to 79, twice as frequent in the maxilla as in the mandible. Histopathological analysis revealed periapical granulomas and cysts. Forty-eight periapical granulomas were studied histobacteriologically. Detailed microscopic analysis of these cases in order to find bacteria was negative. Histopathological analysis of 72 periapical granulomas and 13 cysts (including four follicular cysts) revealed mixed forms apart from homogenous granulomas. In addition changes in the composition of infiltrate cells are rather qualitative than quantitative, therefore classification of periapical lesions into periapical granulomas and cysts seems justified and sufficient for diagnostic and clinical needs. Detailed analysis of cellular composition of periapical granulomas and cysts shows that immunologic agents may play a role in the pathomechanism of these lesions.
Subject(s)
Periapical Granuloma/pathology , Radicular Cyst/pathology , Adult , Aged , Child , Chronic Disease , Female , Humans , Male , Middle Aged , Periapical Granuloma/etiology , Periapical Granuloma/microbiology , Radicular Cyst/etiology , Radicular Cyst/microbiologySubject(s)
Periapical Granuloma/pathology , Adolescent , Adult , Humans , Microscopy, Electron , Middle AgedSubject(s)
Dental Pulp Necrosis/therapy , Periapical Periodontitis/therapy , Root Canal Therapy , Adolescent , Adult , Aged , Bicuspid , Humans , Middle Aged , MolarSubject(s)
Dental Cements , Dental Restoration, Permanent , Glass Ionomer Cements , Adolescent , Adult , Aged , Chemical Phenomena , Chemistry, Physical , Humans , Middle Aged , Surface PropertiesSubject(s)
Administration, Topical , Hydrocortisone , Root Canal Therapy/methods , Adolescent , Adult , Aged , Anti-Inflammatory Agents/administration & dosage , Child , Dental Pulp Diseases/therapy , Dexamethasone/administration & dosage , Drug Combinations/administration & dosage , Evaluation Studies as Topic , Female , Formaldehyde/administration & dosage , Gutta-Percha/administration & dosage , Humans , Male , Middle Aged , Root Canal Filling Materials/administration & dosage , Thymol/administration & dosage , Thymol/analogs & derivativesSubject(s)
Health Education, Dental , Adolescent , Dental Caries/etiology , Female , Humans , Male , Periodontal Diseases/etiology , PolandSubject(s)
Granuloma, Giant Cell/surgery , Periodontal Diseases/surgery , Adolescent , Adult , Aged , Child , Child, Preschool , Female , Follow-Up Studies , Humans , Male , Middle Aged , Periodontal IndexSubject(s)
Gingival Diseases/epidemiology , Granuloma, Giant Cell/epidemiology , Adolescent , Adult , Age Factors , Aged , Child , Child, Preschool , Female , Humans , Male , Middle Aged , Periodontal Diseases/epidemiology , Poland , Sex FactorsSubject(s)
Bismuth , Polyvinyls , Root Canal Filling Materials/therapeutic use , Zinc Oxide , Adolescent , Adult , Aged , Bicuspid , Clinical Trials as Topic , Dental Pulp Necrosis/complications , Dental Pulp Necrosis/diagnostic imaging , Dental Pulp Necrosis/therapy , Drug Combinations , Follow-Up Studies , Humans , Incisor , Middle Aged , Periodontitis/diagnostic imaging , Periodontitis/therapy , Pulpitis/diagnostic imaging , Pulpitis/therapy , RadiographyABSTRACT
A clinical and radiological study was performed to test the utility of Diaket in the conservative treatment of chronic periapical periodontitis. 86% of the treatments were successful with a follow-up of 12 months.
Subject(s)
Periapical Tissue/pathology , Periodontitis/drug therapy , Root Canal Filling Materials/therapeutic use , Adolescent , Adult , Aged , Chronic Disease , Dental Pulp Cavity/diagnostic imaging , Female , Follow-Up Studies , Humans , Male , Middle Aged , RadiographySubject(s)
Root Canal Filling Materials/standards , Adolescent , Adult , Aged , Bismuth , Drug Combinations , Humans , Middle Aged , Polyvinyls , Zinc OxideABSTRACT
Six giant-cell tumors have been examined by electron microscopic methods in order to determine their histogenesis and to expand knowledge of cell structures. The examination of giant cells revealed an abundance of cell organelles, especially mitochondria. Apart from typical stromal cells, such as fibroblasts, macrophages, and mast cells, clusters of stromal "light" cells were often found with an intimate relation between their cell membranes. The role and function of these cells is not well known. Between fibroblasts of regular appearance with a small number of cytoplasmic organelles, others were found with an incrased number of mitochondria. These cells often formed aggregates. This suggests that giant cells develop through the association of stroma fibroblast cells.
