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1.
Pharmacokinetic and metabolic characteristics of ticlopidine in relation to its inhibitory properties on platelet function.
Picard-Fraire, C.
Agents Actions Suppl ; 15: 68-75, 1984.
Article in English | MEDLINE | ID: mdl-6385655

Subject(s)
Anticoagulants/metabolism , Platelet Aggregation/drug effects , Thiophenes/metabolism , Biotransformation , Dose-Response Relationship, Drug , Humans , Kinetics , Thiophenes/pharmacology , Ticlopidine
2.
Human and rat urinary metabolites of the antitumor drug Celiptium (N2-methyl-9-hydroxyellipticinium acetate, NSC 264137). Identification of cysteine conjugates supporting the "biooxidative alkylation" hypothesis.
Monsarrat, B; Maftouh, M; Meunier, G; Dugué, B; Bernadou, J; Armand, J P; Picard-Fraire, C; Meunier, B; Paoletti, C.
Biochem Pharmacol ; 32(24): 3887-90, 1983 Dec 15.
Article in English | MEDLINE | ID: mdl-6661266

Subject(s)
Alkaloids/urine , Antineoplastic Agents/urine , Cysteine/urine , Ellipticines/urine , Alkylation , Animals , Chemical Phenomena , Chemistry , Chromatography, High Pressure Liquid , Female , Humans , Male , Oxidation-Reduction , Rats , Rats, Inbred Strains
3.
Ticlopidine hydrochloride: relationship between dose, kinetics, plasma concentration and effect on platelet function.
Picard-Fraire, C.
Thromb Res Suppl ; 4: 119-28, 1983.
Article in English | MEDLINE | ID: mdl-6356462

ABSTRACT

This is a review of the available data about the pharmacodynamic profile of ticlopidine in man in relation to its pharmacokinetic and metabolic characteristics. There is a rapid dose-dependent onset of effect on platelet function and a time-dependent effect on bleeding. The ticlopidine effect appears to be due to the direct action on circulating platelets. The contributions of a metabolite, a 2-keto derivative, is also discussed.


Subject(s)
Blood Platelets/drug effects , Fibrinolytic Agents , Thiophenes/pharmacology , Adenosine Diphosphate/pharmacology , Animals , Blood Coagulation/drug effects , Collagen/pharmacology , Dose-Response Relationship, Drug , Humans , Kinetics , Platelet Aggregation/drug effects , Rats , Thiophenes/blood , Ticlopidine , Time Factors
4.
Ticlopidine: a promise for the prevention and treatment of thrombosis and its complications.
Panak, E; Maffrand, J P; Picard-Fraire, C; Vallée, E; Blanchard, J; Roncucci, R.
Haemostasis ; 13 Suppl 1: 1-54, 1983.
Article in English | MEDLINE | ID: mdl-6642292

Subject(s)
Anticoagulants/therapeutic use , Thiophenes/therapeutic use , Thrombosis/prevention & control , Animals , Anticoagulants/adverse effects , Anticoagulants/metabolism , Blood Platelets/drug effects , Hemodynamics/drug effects , Humans , Kinetics , Thiophenes/adverse effects , Thiophenes/metabolism , Thiophenes/pharmacology , Thrombosis/complications , Ticlopidine
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