ABSTRACT
Complications of celiac disease could present with intestinal perforation and rarely, gastrointestinal bleeding, which are usually secondary to nongranulomatous ulcerative jejunoileitis or T-cell lymphoma. We describe the case of a 66-year-old male patient with an 8-year history of celiac disease (CD) who presented with recurrent abdominal pain and gastrointestinal bleeding. Several tests were performed to find out possible complications associated to CD. Due to an overt gastrointestinal bleeding, an arteriography was performed and signs of polyarteritis nodosa were found. Vascular disease was aggressive, and despite multiple medical and surgical treatments the patient died. As arteriography is not usually performed for the study of the complications of CD, it is possible that the association between CD and PAN has been underdiagnosed.
Subject(s)
Celiac Disease/complications , Gastrointestinal Hemorrhage/etiology , Intestinal Perforation/etiology , Polyarteritis Nodosa/complications , Aged , Fatal Outcome , Humans , MaleABSTRACT
INTRODUCTION: Celiac disease (CD) is a gluten-sensitive enteropathy characterized by a chronic injury of the small bowel, caused by gluten intolerance in genetically predisposed individuals. The different forms of presentation of CD resemble more a multisystem disorder than a primary gastrointestinal disease and it is frequently underdiagnosed. OBJECTIVE: To determine the prevalence of CD diagnosis in the population of affiliates to the HMO of the Hospital Italiano de Buenos Aires. METHODS: This is a cross sectional study, using secondary databases of diagnosis and laboratory from the electronic medical record (EMR) in a HMO population between 1998 and 2006. The criteria used to define a case was based on a diagnosis of CD in the EMR and/or a IgA antitransglutaminase antibodies value >15 AU/mL. RESULTS: According to these criteria, 283 patients with CD were identified in 128,748 individuals of the HMO. The prevalence of CD was 0.22%. The mean age of this group was of 42.3 years, and 80.2% of them were female. CONCLUSIONS: In a primary care HMO setting, using secondary databases from EMR we found 1 case of celiac disease every 470 affiliates, giving a prevalence of 0.22%. The rate between serological prevalence of CD and clinical diagnosis carried out in our center was near 3.3 to 1. Although this level of diagnosis could be considered relatively high, an important proportion of patients are left without diagnosis, considering the local estimated prevalence reported using serological tests. An increased level of awareness and clinical suspicion is needed at the primary care level.
Subject(s)
Celiac Disease/epidemiology , Adolescent , Adult , Aged , Aged, 80 and over , Argentina/epidemiology , Autoantibodies/blood , Celiac Disease/diagnosis , Child , Child, Preschool , Cross-Sectional Studies , Enzyme-Linked Immunosorbent Assay , Female , Hospitals, Community , Humans , Male , Middle Aged , Prevalence , Transglutaminases/immunology , Young AdultABSTRACT
Objetivo: presentar nuestra experiencia en pacientes con enfermedad de Crohn del intestino delgado evaluados con ecografía Doppler (ED) y resonancia magnética con enteroclisis (RM). Material y métodos: se evaluaron 12 pacientes mediante ED y RM con contraste negativo (bario y metilcelulosa) y gadolinio. Se analizó la presencia de flujo en ED y tinción en la pared de las asas en RM, espesor parietal y complicaciones. Resultados: Todos los pacientes mostraron tinción de la pared por RM y en once flujo por ED. La correlación entre ambos métodos fue total en 10 pacientes. La RM mostró en 10 pacientes áreas de estenosis, mientras que la ecografía en 5 pacientes. Ambos métodos mostraron engrosamiento parietal, y en igual porcentaje fístulas y abscesos. Conclusión: Ambos métodos permiten identificar y cuantificar alteraciones en el intestino delgado en pacientes con enfermedad de Crohn, pudiendo ser útiles en la evaluación y seguimiento de estos pacientes
Subject(s)
Humans , Male , Adult , Female , Middle Aged , Crohn Disease , Barium Sulfate , Crohn Disease , Enema , Fibroblast Growth Factors , Inflammatory Bowel Diseases , Intestine, Small , Magnetic Resonance Imaging , Ultrasonography, DopplerABSTRACT
Objetivo: presentar nuestra experiencia en pacientes con enfermedad de Crohn del intestino delgado evaluados con ecografía Doppler (ED) y resonancia magnética con enteroclisis (RM). Material y métodos: se evaluaron 12 pacientes mediante ED y RM con contraste negativo (bario y metilcelulosa) y gadolinio. Se analizó la presencia de flujo en ED y tinción en la pared de las asas en RM, espesor parietal y complicaciones. Resultados: Todos los pacientes mostraron tinción de la pared por RM y en once flujo por ED. La correlación entre ambos métodos fue total en 10 pacientes. La RM mostró en 10 pacientes áreas de estenosis, mientras que la ecografía en 5 pacientes. Ambos métodos mostraron engrosamiento parietal, y en igual porcentaje fístulas y abscesos. Conclusión: Ambos métodos permiten identificar y cuantificar alteraciones en el intestino delgado en pacientes con enfermedad de Crohn, pudiendo ser útiles en la evaluación y seguimiento de estos pacientes (AU)
